Abstract
Allelic differences at the Ah locus are shown to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences in certain human intracranial neoplasms.
Full Text
The Full Text of this article is available as a PDF (395.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Atlas S. A., Nebert D. W. Pharmacogenetics: a possible pragmatic perspective in neoplasm predictability. Semin Oncol. 1978 Mar;5(1):89–106. [PubMed] [Google Scholar]
- Bickers D. R., Kappas A., Alvares A. P. Differences in inducibility of cutaneous and hepatic drug metabolizing enzymes and cytochrome P-450 by polychlorinated biphenyls and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). J Pharmacol Exp Ther. 1974 Feb;188(2):300–309. [PubMed] [Google Scholar]
- Cohn J. A., Alvares A. P., Kappas A. On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. J Exp Med. 1977 Jun 1;145(6):1607–1611. doi: 10.1084/jem.145.6.1607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hook G. E., Haseman J. K., Lucier G. W. Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Biol Interact. 1975 Mar;10(3):199–214. doi: 10.1016/0009-2797(75)90113-1. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Nebert D. W. Genetic differences in microsomal electron transport: the Ah locus. Methods Enzymol. 1978;52:226–240. doi: 10.1016/s0076-6879(78)52026-0. [DOI] [PubMed] [Google Scholar]
- Pantuck E. J., Hsiao K. C., Conney A. H., Garland W. A., Kappas A., Anderson K. E., Alvares A. P. Effect of charcoal-broiled beef on phenacetin metabolism in man. Science. 1976 Dec 3;194(4269):1055–1057. doi: 10.1126/science.982059. [DOI] [PubMed] [Google Scholar]
- Poland A., Glover E. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene. Mol Pharmacol. 1974 Mar;10(2):349–359. [PubMed] [Google Scholar]
- Sasame H. A., Ames M. M., Nelson S. D. Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites. Biochem Biophys Res Commun. 1977 Oct 10;78(3):919–926. doi: 10.1016/0006-291x(77)90510-1. [DOI] [PubMed] [Google Scholar]