Abstract
The levels of alcohol dehydrogenase (ADH) do not exhibit a structural gene-dosage effect in a one to four dosage series of the long arm of chromosome one (1L) (Birchler 1979). This phenomenon, termed dosage compensation, has been studied in more detail. Experiments are described in which individuals aneuploid for shorter segments were examined for the level of ADH in order to characterize the genetic nature of the compensation. The relative ADH expression in segmental trisomics and tetrasomics of region 1L 0.72–0.90, which includes the Adh locus, approaches the level expected from a strict gene dosage effect. Region 1L 0.20–0.72 produces a negative effect upon ADH in a similar manner to that observed with other enzyme levels when 1L as a whole is varied (Birchler 1979). These and other comparisons have led to the concept that the compensation of ADH results from the cancellation of the structural gene effect by the negative aneuploid effect. The example of ADH is discussed as a model for certain other cases of dosage compensation in higher eukaryotes.
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Selected References
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- Birchler J. A. A study of enzyme activities in a dosage series of the long arm of chromosome one in maize. Genetics. 1979 Aug;92(4):1211–1229. doi: 10.1093/genetics/92.4.1211. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Freeling M. Further Studies on the Balance between Adh and Adh in Maize: Gene Competitive Programs. Genetics. 1975 Dec;81(4):641–654. doi: 10.1093/genetics/81.4.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Freeling M., Schwartz D. Genetic relationships between the multiple alcohol dehydrogenases of maize. Biochem Genet. 1973 Jan;8(1):27–36. doi: 10.1007/BF00485554. [DOI] [PubMed] [Google Scholar]
- Goodman M. M., Stuber C. W., Newton K., Weissinger H. H. Linkage relationships of 19 enzyme Loci in maize. Genetics. 1980 Nov;96(3):697–710. doi: 10.1093/genetics/96.3.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schimke R. T., Kaufman R. J., Alt F. W., Kellems R. F. Gene amplification and drug resistance in cultured murine cells. Science. 1978 Dec 8;202(4372):1051–1055. doi: 10.1126/science.715457. [DOI] [PubMed] [Google Scholar]
- Schwartz D. Genetic control of alcohol dehydrogenase--a competition model for regulation of gene action. Genetics. 1971 Mar;67(3):411–425. doi: 10.1093/genetics/67.3.411. [DOI] [PMC free article] [PubMed] [Google Scholar]