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. 1981 Sep;99(1):109–116. doi: 10.1093/genetics/99.1.109

γ-Glutamyl Cyclotransferase: A New Genetic Polymorphism in the Mouse (MUS MUSCULUS) Linked to LYT–2

Natalie Tulchin 1,2, Benjamin A Taylor 1,2
PMCID: PMC1214482  PMID: 6122625

Abstract

Electrophoretically variant forms of γ-glutamyl cyclotransferase have been identified in red cells of inbred mouse strains. Each inbred strain exhibited a major band of activity and a minor band that migrated more anodally. The polymorphism affects the migration of both the major and minor bands in a similar way. F1 hybrids between strains with fast forms (A/J) and strains with the slow forms (C57BL/6J) exhibited a four-banded pattern consistent with co-dominant inheritance. The patterns observed in backcross and F2 mice were consistent with the segregation of a pair of autosomal co-dominant alleles. Recombinant inbred strains and a congenic strain were used to show that the locus controlling γ-glutamyl cyclotransferase (Ggc) is linked to Lyt-2, a lymphocyte alloantigen locus on chromosome 6, with an estimated map distance of 5.0 ± 2.5 centimorgans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bradley D. J., Taylor B. A., Blackwell J., Evans E. P., Freeman J. Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin Exp Immunol. 1979 Jul;37(1):7–14. [PMC free article] [PubMed] [Google Scholar]
  2. CONNELL G. E., HANES C. S. Enzymic formation of pyrrolidone carboxylic acid from gamma-glutamyl peptides. Nature. 1956 Feb 25;177(4504):377–378. doi: 10.1038/177377a0. [DOI] [PubMed] [Google Scholar]
  3. Connell G. E., Szewczuk A. The properties of gamma-glutamyl lactamase in man. Clin Chim Acta. 1967 Sep;17(3):423–430. doi: 10.1016/0009-8981(67)90218-5. [DOI] [PubMed] [Google Scholar]
  4. Gibson D. M., Taylor B. A., Cherry M. Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus. J Immunol. 1978 Oct;121(4):1585–1590. [PubMed] [Google Scholar]
  5. Orlowski M., Meister A. -Glutamyl cyclotransferase. Distribution, isozymic forms, and specificity. J Biol Chem. 1973 Apr 25;248(8):2836–2844. [PubMed] [Google Scholar]
  6. Orlowski M., Richman P. G., Meister A. Isolation and properties of gamma-L-glutamylcyclotransferase from human brain. Biochemistry. 1969 Mar;8(3):1048–1055. doi: 10.1021/bi00831a036. [DOI] [PubMed] [Google Scholar]
  7. Orlowski M., Wilk S. Intermediates of the gamma-glutamyl cycle in mouse tissues. Influence of administration of amino acids on pyrrolidone carboxylate and gamma-glutamyl amino acids. Eur J Biochem. 1975 May 6;53(2):581–590. doi: 10.1111/j.1432-1033.1975.tb04101.x. [DOI] [PubMed] [Google Scholar]
  8. Taylor B. A., Bailey D. W., Cherry M., Riblet R., Weigert M. Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature. 1975 Aug 21;256(5519):644–646. doi: 10.1038/256644a0. [DOI] [PubMed] [Google Scholar]
  9. Taylor B. A., Bedigian H. G., Meier H. Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines. J Virol. 1977 Jul;23(1):106–109. doi: 10.1128/jvi.23.1.106-109.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]

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