Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1974 Apr;58(4):344–366. doi: 10.1136/bjo.58.4.344

Vascular basement membrane changes in diabetic retinopathy. Montgomery lecture, 1973.

N Ashton
PMCID: PMC1214780  PMID: 4138036

Full text

PDF
344

Images in this article

359Image
on p.359
346Image
on p.346
351Image
on p.351
351Image
on p.351
352Image
on p.352
353Image
on p.353
354Image
on p.354
355Image
on p.355
356Image
on p.356
358Image
on p.358
360Image
on p.360
361Image
on p.361

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AAGENAES O., MOE H. Light- and electron-microscopic study of skin capillaries of diabetics. Diabetes. 1961 Jul-Aug;10:253–259. doi: 10.2337/diab.10.4.253. [DOI] [PubMed] [Google Scholar]
  2. ANDERSON G. S. The pathogenesis of diabetic glomerulosclerosis. J Pathol Bacteriol. 1954 Jan;67(1):241–245. doi: 10.1002/path.1700670129. [DOI] [PubMed] [Google Scholar]
  3. ASHWORTH C. T., RDMANN R. R., ARNOLD N. J. Age changes in the renal basement membrane in rats. Am J Pathol. 1960 Feb;36:165–179. [PMC free article] [PubMed] [Google Scholar]
  4. BANSON B. B., LACY P. E. DIABETIC MICROANGIOPATHY IN HUMAN TOES; WITH EMPHASIS ON THE ULTRASTUCTURAL CHANGE IN DERMAL CAPILLARIES. Am J Pathol. 1964 Jul;45:41–58. [PMC free article] [PubMed] [Google Scholar]
  5. BECKER B., COLEMAN S. L., KEATES E. U. Gamma globulin in ocular diseases: diabetes and glaucoma. Trans Am Ophthalmol Soc. 1962;60:260–267. [PMC free article] [PubMed] [Google Scholar]
  6. BECKER D., MILLER M. Presence of diabetic glomerulosclerosis in patients with hemochromatosis. N Engl J Med. 1960 Aug 25;263:367–373. doi: 10.1056/NEJM196008252630801. [DOI] [PubMed] [Google Scholar]
  7. BENCOSME S. A., BERGMAN B. J. The ultrastructure of human and experimental glomerular lesions. Int Rev Exp Pathol. 1962;1:139–208. [PubMed] [Google Scholar]
  8. BERGSTRAND A., BUCHT H. Electron microscopic investigations on the glomerular lesions in diabetes mellitus (diabetic glomerulosclerosis). Lab Invest. 1957 Jul-Aug;6(4):293–300. [PubMed] [Google Scholar]
  9. BERNS A. W., OWENS C. T., HIRATA Y., BLUMENTHAL H. T. The pathogenesis of diabetic glomerulosclerosis. II. A demonstration of insulin-binding capacity of the various histopathological components of the disease by fluorescence microscopy. Diabetes. 1962 Jul-Aug;11:308–317. [PubMed] [Google Scholar]
  10. BIAVA C. G., DYRDA I., GENEST J., BENCOSME S. A. RENAL HYALINE ARTERIOLOSCLEROSIS. AN ELECTRON MICROSCOPE STUDY. Am J Pathol. 1964 Mar;44:349–363. [PMC free article] [PubMed] [Google Scholar]
  11. BLOODWORTH J. M., Jr Diabetic retinopathy. Diabetes. 1962 Jan-Feb;11:1–22. [PubMed] [Google Scholar]
  12. CEDERGREN B., GYLLENSTEN L., WERSALL J. Pulmonary damage caused by oxygen poisoning: an electron-microscopic study in mice. Acta Paediatr. 1959 Sep;48:477–494. [PubMed] [Google Scholar]
  13. COLEMAN S. L., BECKER B., CANAAN S., ROSENBAUM L. Fluorescent insulin staining of the diabetic eye. Diabetes. 1962 Sep-Oct;11:375–377. [PubMed] [Google Scholar]
  14. DACHS S., CHURG J., MAUTNER W., GRISHMAN E. DIABETIC NEPHROPATHY. Am J Pathol. 1964 Jan;44:155–168. [PMC free article] [PubMed] [Google Scholar]
  15. DUNCAN L. J., MACFARLANE A., ROBSON J. S. Diabetic retinopathy and nephropathy in pancreatic diabetes. Lancet. 1958 Apr 19;1(7025):822–826. doi: 10.1016/s0140-6736(58)91742-2. [DOI] [PubMed] [Google Scholar]
  16. Davies M. J., Woolf N., Carstairs K. C. Immunohistochemical studies in diabetic glomerulosclerosis. J Pathol Bacteriol. 1966 Oct;92(2):441–445. doi: 10.1002/path.1700920223. [DOI] [PubMed] [Google Scholar]
  17. DiScala V. A., Salomon M., Grishman E., Churg J. Renal structure in myxedema. Arch Pathol. 1967 Nov;84(5):474–485. [PubMed] [Google Scholar]
  18. Erlanson P., Lindqvist B., Lundh G. Hypersecreting villous rectal papilloma leading to excessive electrolyte-fluid losses and acute renal failure. Acta Med Scand. 1967 Jul;182(1):5–10. doi: 10.1111/j.0954-6820.1967.tb11495.x. [DOI] [PubMed] [Google Scholar]
  19. FAGERBERG S. E. Studies on the pathogenesis of diabetic neuropathy; survey of the literature and own working hypothesis. Acta Med Scand. 1956 Mar 26;154(2):145–150. doi: 10.1111/j.0954-6820.1956.tb14308.x. [DOI] [PubMed] [Google Scholar]
  20. FREEDMAN P., PETERS J. H., KARK R. M. Localization of gamma-globulin in the diseased kidney. Arch Intern Med. 1960 Apr;105:524–535. doi: 10.1001/archinte.1960.00270160022005. [DOI] [PubMed] [Google Scholar]
  21. Farid N. R., Wilkinson E., Constable F. L., Anderson J. Basement membrane thickness of rectal capillaries in diabetes. Lancet. 1973 Apr 14;1(7807):837–837. doi: 10.1016/s0140-6736(73)90648-x. [DOI] [PubMed] [Google Scholar]
  22. Farquhar A., MacDonald M. K., Ireland J. T. The role of fibrin deposition in diabetic glomerulosclerosis: a light, electron and immunofluorescence microscopy study. J Clin Pathol. 1972 Aug;25(8):657–667. doi: 10.1136/jcp.25.8.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Fisher E. R., Perez-Stable E., Amidi M., Sarver M. E., Danowski T. S. Ultrastructural renal changes in juvenile diabetics. JAMA. 1967 Oct 23;202(4):291–295. [PubMed] [Google Scholar]
  24. Friederici H. H., Tucker W. R., Schwartz T. B. Observations on small blood vessels of skin in the normal and in diabetic patients. Diabetes. 1966 Apr;15(4):233–250. doi: 10.2337/diab.15.4.233. [DOI] [PubMed] [Google Scholar]
  25. GERSH I., CATCHPOLE H. R. The organization of ground substance and basement membrane and its significance in tissue injury disease and growth. Am J Anat. 1949 Nov;85(3):457-521, incl 7 pl. doi: 10.1002/aja.1000850304. [DOI] [PubMed] [Google Scholar]
  26. GOLDENBERG S., ALEX M., JOSHI R. A., BLUMENTHAL H. T. Nonatheromatous peripheral vascular disease of the lower extremity in diabetes mellitus. Diabetes. 1959 Jul-Aug;8(4):261–273. doi: 10.2337/diab.8.4.261. [DOI] [PubMed] [Google Scholar]
  27. González-Angulo A., Fraga A., Mintz G. Submicroscopic alterations in capillaries of skeletal muscles in polymyositis. Am J Med. 1968 Dec;45(6):873–879. doi: 10.1016/0002-9343(68)90185-x. [DOI] [PubMed] [Google Scholar]
  28. HANDELSMAN M. B., MORRIONE T. G., GHITMAN B. Skin vascular alterations in diabetes mellitus. Arch Intern Med. 1962 Jul;110:70–77. doi: 10.1001/archinte.1962.03620190072011. [DOI] [PubMed] [Google Scholar]
  29. ISHIKAWA T. Fine structure of retinal vessels in man and the macaque monkey. Invest Ophthalmol. 1963 Feb;2:1–15. [PubMed] [Google Scholar]
  30. KIMMELSTIEL P., KIM O. J., BERES J. Studies on renal biopsy specimens, with the aid of the electron microscope. II. Glomerulonephritis and glomerulonephrosis. Am J Clin Pathol. 1962 Sep;38:280–296. doi: 10.1093/ajcp/38.3.280. [DOI] [PubMed] [Google Scholar]
  31. KISSEN A. T., BLOODWORTH J. M., Jr Ultrastructure of retinal capillaries of the rat. Exp Eye Res. 1961 Sep;1:1–4. doi: 10.1016/s0014-4835(61)80002-x. [DOI] [PubMed] [Google Scholar]
  32. LANNIGAN R., BLAINEY J. D., BREWER D. B. ELECTRON MICROSCOPY OF THE DIFFUSE GLOMERULAR LESION IN DIABETES MELLITUS WITH SPECIAL REFERENCE TO EARLY CHANGES. J Pathol Bacteriol. 1964 Jul;88:255–261. [PubMed] [Google Scholar]
  33. LENDRUM A. C. Further observations on fibrinous vasculosis. Ned Tijdschr Geneeskd. 1961 Jul 8;105:1359–1360. [PubMed] [Google Scholar]
  34. Larsen H. W., Werner A. U. Immunohistological studies on human diabetic and non-diabetic eyes. II. Autoradiography using I-125-labelled insulin and application of histochemical procedures. Acta Ophthalmol (Copenh) 1969;47(4):956–971. doi: 10.1111/j.1755-3768.1969.tb03719.x. [DOI] [PubMed] [Google Scholar]
  35. Lendrum A. C., Slidders W., Fraser D. S. Renal hyalin. A study of amyloidosis and diabetic fibrinous vasculosis with new staining methods. J Clin Pathol. 1972 May;25(5):373–396. doi: 10.1136/jcp.25.5.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. MAYNARD E. A., SCHULTZ R. L., PEASE D. C. Electron microscopy of the vascular bed of rat cerebral cortex. Am J Anat. 1957 May;100(3):409–433. doi: 10.1002/aja.1001000306. [DOI] [PubMed] [Google Scholar]
  37. MCGEE W. G., ASHWORTH C. T. FINE STRUCTURE OF CHRONIC HYPERTENSIVE ARTERIOPATHY IN THE HUMAN KIDNEY. Am J Pathol. 1963 Aug;43:273–299. [PMC free article] [PubMed] [Google Scholar]
  38. MIDGLEY A. R., Jr, PIERCE G. B., Jr IMMUNOHISTOCHEMICAL ANALYSIS OF BASEMENT MEMBRANES OF THE MOUSE. Am J Pathol. 1963 Dec;43:929–943. [PMC free article] [PubMed] [Google Scholar]
  39. PIERCE G. B., Jr, MIDGLEY A. R., Jr, SRI RAM J. The histogenesis of basement membranes. J Exp Med. 1963 Mar 1;117:339–348. doi: 10.1084/jem.117.3.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. PROSE P. H., LEE L., BALK S. D. ELECTRON MICROSCOPIC STUDY OF THE PHAGOCYTIC FIBRIN-CLEARING MECHANISM. Am J Pathol. 1965 Sep;47:403–417. [PMC free article] [PubMed] [Google Scholar]
  41. Shakib M., Cunha-Vaz J. G., Keith C. G. Studies on the effects of osmotically active substances on the circulation and structure of the retina. II. Electron microscopical studies. Invest Ophthalmol. 1967 Apr;6(2):198–206. [PubMed] [Google Scholar]
  42. Siperstein M. D., Unger R. H., Madison L. L. Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients. J Clin Invest. 1968 Sep;47(9):1973–1999. doi: 10.1172/JCI105886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Sosula L., Beaumont P., Jonson K. M., Hollows F. C. Quantitative ultrastructure of capillaries in the rat retina. Invest Ophthalmol. 1972 Nov;11(11):916–925. [PubMed] [Google Scholar]
  44. Spiro R. G. Glycoproteins: their biochemistry, biology and role in human disease. N Engl J Med. 1969 Nov 6;281(19):1043–concl. doi: 10.1056/NEJM196911062811905. [DOI] [PubMed] [Google Scholar]
  45. TOMLIN S. G. Reticulin and collagen. Nature. 1953 Feb 14;171(4346):302–302. doi: 10.1038/171302a0. [DOI] [PubMed] [Google Scholar]
  46. TOUSSAINT D., DUSTIN P. Electron microscopy of normal and diabetic retinal capillaries. Arch Ophthalmol. 1963 Jul;70:96–108. doi: 10.1001/archopht.1963.00960050098015. [DOI] [PubMed] [Google Scholar]
  47. Tripathi R., Ashton N. Electron microscopical study of Coat's disease. Br J Ophthalmol. 1971 May;55(5):289–301. doi: 10.1136/bjo.55.5.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Vracko R. Skeletal muscle capillaries in diabetics. A quantitative analysis. Circulation. 1970 Feb;41(2):271–283. doi: 10.1161/01.cir.41.2.271. [DOI] [PubMed] [Google Scholar]
  49. Vracko R., Strandness D. E., Jr Basal lamina of abdominal skeletal muscle capillaries in diabetics and nondiabetics. Circulation. 1967 Apr;35(4):690–700. doi: 10.1161/01.cir.35.4.690. [DOI] [PubMed] [Google Scholar]
  50. WIENER J., SPIRO D., LATTES R. G. THE CELLULAR PATHOLOGY OF EXPERIMENTAL HYPERTENSION. II. ARTERIOLAR HYALINOSIS AND FIBRINOID CHANGE. Am J Pathol. 1965 Sep;47:457–485. [PMC free article] [PubMed] [Google Scholar]
  51. Werner A. U., Larsen H. W. Immunohistological studies on human diabetic and non-diabetic eyes. I. Fluorescent labelling of insulin and insulin antibodies. Acta Ophthalmol (Copenh) 1969;47(4):937–955. doi: 10.1111/j.1755-3768.1969.tb03718.x. [DOI] [PubMed] [Google Scholar]
  52. Westberg N. G., Michael A. F. Immunohistopathology of diabetic glomerulosclerosis. Diabetes. 1972 Mar;21(3):163–174. doi: 10.2337/diab.21.3.163. [DOI] [PubMed] [Google Scholar]
  53. Williamson J. R., Vogler N. J., Kilo C. Regional variations in the width of the basement membrane of muscle capillaries in man and giraffe. Am J Pathol. 1971 May;63(2):359–370. [PMC free article] [PubMed] [Google Scholar]
  54. YAMASHITA T., BECKER B. The basement membrane in the human diabetic eye. Diabetes. 1961 May-Jun;10:167–174. doi: 10.2337/diab.10.3.167. [DOI] [PubMed] [Google Scholar]
  55. ZACKS S. I., PEGUES J. J., ELLIOTT F. A. Interstitial muscle capillaries in patients with diabetes mellitus: a light and electron microscope study. Metabolism. 1962 Apr;11:381–393. [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES