ABSTRACT
Wheatgrass juice (WGJ), extracted from the young grass of Triticum aestivum, is an emerging natural health remedy with diverse therapeutic properties. Its rich composition of chlorophyll, vitamins, minerals, amino acids, and antioxidants makes it a functional food with potential applications in managing chronic diseases and promoting overall health. WGJ has demonstrated efficacy in reducing oxidative stress, improving hemoglobin levels in anemia, detoxifying the body, and enhancing immunity. Additionally, it has shown promise as an adjunct in cancer treatment, cardiovascular health, and gastrointestinal disorders. Despite its broad usage, most of the evidence supporting WGJ’s benefits comes from limited studies, emphasizing the need for more rigorous scientific validation. This narrative review explores the nutritional profile, bioactive compounds, and therapeutic applications of WGJ while addressing its limitations and potential for integration into modern medicine.
KEYWORDS: Anemia, anti-inflammatory, antioxidant, cancer therapy, cardiovascular health, chlorophyll, functional food, immunity, Triticum aestivum, wheatgrass juice
INTRODUCTION
Wheatgrass juice (WGJ), derived from the young shoots of Triticum aestivum, has gained prominence as a natural therapeutic agent due to its rich nutritional profile and potential health benefits.[1] Renowned for its high concentration of vitamins, minerals, enzymes, and phytonutrients, WGJ has been widely used in alternative medicine and dietary supplementation. Its unique composition, which includes chlorophyll, flavonoids, phenolic compounds, and essential amino acids, positions it as a functional food with applications in promoting overall health and managing various chronic conditions.[2] The therapeutic potential of WGJ extends to multiple health domains, including its antioxidant, anti-inflammatory, and detoxifying properties. It has been explored as a supportive agent in managing anemia, cancer, diabetes, cardiovascular diseases, and gastrointestinal disorders. Studies have also highlighted its potential to enhance immunity, improve metabolism, and mitigate oxidative stress. These attributes are largely attributed to the synergistic effects of its bioactive components, which work at cellular and systemic levels. Despite its growing popularity, scientific validation of WGJ’s health claims remains limited, with most evidence being anecdotal or derived from small-scale studies.[3] This narrative review aims to explore the nutritional and medicinal properties of WGJ, discuss its bioactive components, and examine its applications in modern healthcare.[4] By bridging the gap between traditional knowledge and scientific research, this article seeks to provide insights into the potential role of WGJ in preventive and therapeutic medicine.
NUTRITIONAL COMPOSITION AND BIOACTIVE COMPONENTS
WGJ is a powerhouse of essential nutrients and bioactive compounds, contributing to its status as a functional food. It is rich in vitamins such as A, C, E, and B-complex; minerals including iron, calcium, magnesium, and potassium; and amino acids and enzymes. The high chlorophyll content, which constitutes approximately 70% of its dry weight, is a key component of its therapeutic potential. Chlorophyll, often referred to as “green blood,” has a molecular structure similar to hemoglobin, enabling it to enhance oxygen transport and detoxify the body.[5] WGJ also contains a wide array of antioxidants, such as flavonoids, phenolic acids, and saponins, which combat oxidative stress by neutralizing free radicals. Enzymes like superoxide dismutase (SOD) and cytochrome oxidase further enhance its antioxidant capacity, protecting cells from damage and promoting cellular repair. Additionally, WGJ provides essential amino acids, including arginine, lysine, and tryptophan, which are crucial for protein synthesis and metabolic functions.[6] The nutritional profile of WGJ makes it particularly effective in addressing deficiencies and improving overall health. Its bioactive components contribute to its anti-inflammatory, antimicrobial, and immune-modulatory effects, which have been associated with the prevention and management of chronic diseases. The synergy between these components underpins its therapeutic versatility, making it a valuable supplement in both preventive and curative healthcare.[7]
Table 1 below provides a concise summary of the nutritional and bioactive components of WGJ and their respective roles in promoting health.
Table 1.
Nutritional composition and bioactive components of wheatgrass juice
| Component | Examples/Details | Role in Health |
|---|---|---|
| Vitamins | A, C, E, B-complex | Antioxidant protection, immune support, skin and vision health |
| Minerals | Iron, Calcium, Magnesium, Potassium | Hemoglobin synthesis, bone health, muscle function, electrolyte balance |
| Chlorophyll | ~70% of dry weight | Enhances oxygen transport, detoxifies the body, promotes wound healing |
| Antioxidants | Flavonoids, Phenolic acids, Saponins | Neutralize free radicals, reduce oxidative stress |
| Enzymes | Superoxide dismutase (SOD), Cytochrome oxidase | Protect cells from damage, support cellular repair |
| Amino Acids | Arginine, Lysine, Tryptophan | Protein synthesis, metabolic regulation, immune support |
| Other Bioactives | Alkaloids, Tannins | Anti-inflammatory, antimicrobial properties |
Table 2 below represents the nutritional profile of WGJ per 100 ml, which highlights its exceptional energy content (327 Kcal) and a rich supply of protein (12.63 g), carbohydrates (71.18 g), and dietary fiber (12.2 g). It is a powerhouse of essential micronutrients, including high levels of iron (126 mg), potassium (363 mg), and phosphorus (288 mg), along with vitamins such as E (1.01 mg), niacin (5.464 mg), and folate (38 μg), emphasizing its role as a highly nutritious functional beverage.
Table 2.
Nutritional values of WGJ (per 100 ml of juice)
| Nutrients | Nutritional Values |
|---|---|
| Energy- 327 Kcal | Protein- 12.63g |
| Carbohydrates- 71.18g Sugar- 0.41g Dietary fiber- 12.2g | Fat- 1.54g |
| Iron- 126 mg | Calcium- 29 mg |
| Magnesium- 3.985 mg | Phosphorus- 288 mg |
| Potassium- 363 mg | Sodium- 2 mg |
| Thiamine- 0.383 mg | Riboflavin- 0.115 mg |
| Niacin- 5.464 mg | Pantothenic acid- 0.954 mg |
| Pyridoxine- 0.3 mg | Folate - 38 µg |
| Vitamin E- 1.01 mg | Choline - 3.12 mg |
| Vitamin K- 1.9 µg | Zinc (28%) 2.65 mg |
Therapeutic applications
WGJ has gained recognition for its extensive therapeutic potential, supported by its rich nutritional and bioactive composition. One of its most notable applications is in managing anemia, where its high chlorophyll content, structurally similar to hemoglobin, aids in enhancing red blood cell production and improving oxygen transport.[4] Studies have demonstrated significant improvements in hemoglobin levels among patients consuming WGJ regularly, particularly those with iron-deficiency anemia. In oncology, WGJ has shown promise as an adjunct therapy, helping to mitigate the side effects of chemotherapy and radiation, including fatigue, anemia, and mucositis. Its antioxidant properties, derived from bioactive compounds like flavonoids and phenolic acids, reduce oxidative stress and protect healthy cells during cancer treatment. Additionally, WGJ exhibits anti-inflammatory effects that support cardiovascular health by reducing arterial inflammation and improving lipid profiles. WGJ is also effective in gastrointestinal health, where its fiber content promotes digestion and alleviates constipation. Its detoxifying properties help eliminate toxins, reduce liver overload, and support renal health.[8] Emerging evidence suggests its role in managing diabetes by improving glycemic control and enhancing insulin sensitivity. Collectively, these therapeutic applications highlight the versatile role of WGJ as a supportive agent in modern healthcare.
Limitations and challenges
Despite its therapeutic potential, WGJ faces limitations, including a lack of large-scale clinical trials validating its efficacy and variability in preparation methods affecting consistency. Its short shelf life and strong taste may limit its appeal and accessibility. While generally safe, excessive consumption can cause mild side effects such as nausea or allergic reactions in sensitive individuals. Addressing these challenges through standardization and rigorous research is essential to enhance its acceptance and utility.
CONCLUSION
WGJ stands out as a nutritionally dense and bioactive-rich functional food with promising therapeutic applications. Its potential in managing conditions such as anemia, cancer, cardiovascular diseases, and gastrointestinal disorders underscores its versatility in modern healthcare. However, the current evidence is limited by a lack of large-scale clinical studies, emphasizing the need for further research to validate its efficacy, standardize its production, and address its limitations. WGJ holds great promise as a natural, supportive agent in preventive and therapeutic medicine.
Conflicts of interest
There are no conflicts of interest.
Funding Statement
Nil.
REFERENCES
- 1.Bar-Sela G, Cohen M, Ben-Arye E, Epelbaum R. The medical use of wheatgrass: Review of the gap between basic and clinical applications. Mini Rev Med Chem. 2015;15:1002–10. doi: 10.2174/138955751512150731112836. [DOI] [PubMed] [Google Scholar]
- 2.Parit SB, Dawkar VV, Tanpure RS, Pai SR, Chougale AD. Nutritional quality and antioxidant activity of wheatgrass (triticum aestivum) unwrap by proteome profiling and DPPH and FRAP assays. J Food Sci. 2018;83:2127–39. doi: 10.1111/1750-3841.14224. [DOI] [PubMed] [Google Scholar]
- 3.Ahmed Z, Faisal Manzoor M, Hussain A, Hanif M, Zia-Ud-Din, Zeng XA. Study the impact of ultra-sonication and pulsed electric field on the quality of wheat plantlet juice through FTIR and SERS. Ultrason Sonochem. 2021;76:105648. doi: 10.1016/j.ultsonch.2021.105648. doi: 10.1016/j.ultsonch.2021.105648. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Bar-Sela G, Cohen M, Ben-Arye E, Epelbaum R. The Medical Use of Wheatgrass: Review of the Gap Between Basic and Clinical Applications. Mini Rev Med Chem. 2015;15:1002–10. doi: 10.2174/138955751512150731112836. [doi: 10.2174/138955751512150731112836] [DOI] [PubMed] [Google Scholar]
- 5.Bianchi G, Falcinelli B, Tosti G, Bocci L, Benincasa P. Taste quality traits and volatile profiles of sprouts and wheatgrass from hulled and non-hulled Triticum species. J Food Biochem. 2019;43:e12869. doi: 10.1111/jfbc.12869. doi: 10.1111/jfbc.12869. [DOI] [PubMed] [Google Scholar]
- 6.Vidyadhar S, Tripathi R. Charaka Samhita. Vol. 14. Varanasi: Choukhamba Sanskrit Pratisthan; 2005. [Google Scholar]
- 7.Kumar NS, Murali M, Nair AM, Nair AS. Green blood therapy of wheat grass-nature's finest medicine'- A literature review. J Pharm Biol Sci. 2016;11:57–64. [Google Scholar]
- 8.Padalia S, Drabu S, Raheja I, Gupta A, Dhamija M. Multitude potential of wheatgrass juice (green blood) An overview. Chronicles Young Scientists. 2010;1:23–8. [Google Scholar]