Table 2.

Changes in total and individual domain scores of FACT-P

Domain	Week	Group	Mean ± SD (n)	t-test
1. Physical	1	MAB	0.53 ± 2.90 (93)	P = 0.229*
		Monotherapy	0.02 ± 2.86 (94)
	5	MAB	0.56 ± 2.91 (93)	P = 0.209*
		Monotherapy	0.00 ± 3.15 (94)
	24	MAB	0.70 ± 3.94 (93)	P = 0.072*
		Monotherapy	−0.27 ± 3.41 (94)
2. Social/family	1	MAB	−1.15 ± 7.59 (94)	P = 0.711*
		Monotherapy	−1.55 ± 7.14 (96)
	5	MAB	−1.21 ± 8.29 (94)	P = 0.131*
		Monotherapy	−2.96 ± 7.64 (96)
	24	MAB	−2.31 ± 8.18 (94)	P = 0.724*
		Monotherapy	−1.89 ± 8.32 (96)
3. Emotional	1	MAB	1.39 ± 3.25 (93)	P  = 0.027*
		Monotherapy	0.36 ± 3.12 (95)
	5	MAB	1.55 ± 3.89 (93)	P = 0.132*
		Monotherapy	0.70 ± 3.87 (95)
	24	MAB	2.21 ± 4.19 (93)	P = 0.075*
		Monotherapy	1.16 ± 3.82 (95)
4. Functional	1	MAB	−0.76 ± 3.71 (94)	P = 0.870*
		Monotherapy	−0.85 ± 3.82 (96)
	5	MAB	0.21 ± 4.05 (94)	P = 0.063†
		Monotherapy	−1.11 ± 5.56 (96)
	24	MAB	0.24 ± 5.95 (94)	P = 0.924*
		Monotherapy	0.32 ± 5.44 (96)
5. Prostate cancer-specific issues	1	MAB	0.88 ± 5.55 (92)	P = 0.672*
		Monotherapy	0.52 ± 5.97 (93)
	5	MAB	3.14 ± 5.92 (92)	P  = 0.011*
		Monotherapy	0.90 ± 5.94 (93)
	24	MAB	4.15 ± 7.40 (92)	P = 0.117*
		Monotherapy	2.43 ± 7.37 (93)
Total score	1	MAB	0.84 ± 12.37 (94)	P = 0.199*
		Monotherapy	−1.53 ± 12.97 (96)
	5	MAB	4.16 ± 12.72 (94)	P  < 0.001*
		Monotherapy	−2.52 ± 13.06 (96)
	24	MAB	4.86 ± 18.44 (94)	P = 0.228*
		Monotherapy	1.67 ± 17.97 (96)

Positive change denotes improvement of QOL

MAB maximum androgen blockade

* Student’s t-test; ^† Welch’s t-test (when equality of variance was rejected at P = 0.05)

Bold entries indicate P<0.05