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(Cancer Cell 39, 649–661.e1–e5; May 10, 2021)
We, the authors of the paper, characterized the single-cell transcriptomes of cancer and immune cells from patients with advanced clear cell renal cell carcinoma before or after immune checkpoint blockade to identify mechanisms of response or resistance to treatment. In the original published version of the paper, the disease stage for patient P915 was reported as stage IV in Figure 1B and in Table S1. However, a recent re-review of the patient’s clinical course showed that at the time of biopsy, the patient’s disease was in fact stage III, with no distant metastases. We have now provided corrected versions of Figure 1 and tab A from Table S1 to accurately reflect the patient’s staging. As patient stage was not used as a covariate in any analyses, the correction does not affect any results or conclusions of the study. We apologize for any confusion this error may have caused.
Figure 1. Characterizing the tumor microenvironment of advanced RCC during therapy
Table S1.
Clinical variables for samples and patients, basic metadata for all cells, and differential expression results for initial Louvain clusters and final cell types
| Sample | Study ID | Age at Dx | Sex | ICB | Duration of ICB Regimen | Time from end of ICB to Biopsy | ICB Response | TKI-exposed | Biopsy Site | Histology | Grade | Stage | Cells Recovered Post-QC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P55 | 0600855_T3 | 57 | M | aPD-1 | 24 mo. | -2 mo. | PR | TKI | Abdominal Mass | Clear cell | 3 | IV | 4637 |
| P915 | 0600915_T1 | 58 | M | aPD-1 + aCTLA-4 | 2 mo. | 3 mo. | PR | No TKI | Kidney | Clear cell | 3 | III | 6541 |
| P913 | 0600913_T1 | 47 | M | aPD1 + VEGF TKI | 10 mo. | 2 mo. | SD | TKI | Lung | Clear cell | 4 | IV | 3744 |
| P906 | 0600906_T1 | 62 | M | aPD-1 | 15 mo. | 6 mo. | PD | TKI | Lymph node | Papillary | 3 | IV | 2470 |
| P912 | 0600912_T1 | 60 | M | aPD1 + VEGF TKI | 17 mo. | < 1 mo. | NE | TKI | Lymph node | Clear cell | 4 | IV | 280 |
| P76 | 0600876_T1 | 68 | F | No ICB | N/A | N/A | N/A | No TKI | Kidney | Clear cell | 4 | IV | 7912 |
| P916 | 0600916_T1 | 61 | M | No ICB | N/A | N/A | N/A | No TKI | Lymph node | Clear cell | 4 | IV | 316 |
| P90 | 0600890_T1 | 71 | F | No ICB | N/A | N/A | N/A | No TKI | Kidney | Clear cell | 4 | I | 8426 |