Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1988 Sep;60(3):201–203. doi: 10.1136/hrt.60.3.201

Thrombin and plasmin activity in coronary artery disease.

M Small 1, G D Lowe 1, J T Douglas 1, I Hutton 1, A R Lorimer 1, C D Forbes 1
PMCID: PMC1216554  PMID: 2972304

Abstract

Basal plasmin and thrombin activity in plasma were assessed by radioimmunoassay of the fibrinogen derivatives containing the sequence B beta 15-42 and of fibrinopeptide A respectively in a cross sectional controlled study of men with coronary artery disease. Compared with healthy controls (n = 33) men with angiographically defined coronary artery disease (n = 98) had a modest but significant increase in concentrations of fibrinopeptide A, indicating an activated coagulation system. Concentrations of B beta 15-42 were similar in those with coronary artery disease and in the controls. The enhanced thrombin activity in coronary artery disease is in keeping with current evidence suggesting an association between coronary artery disease and a hypercoagulable state.

Full text

PDF
201

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASTRUP T. The haemostatic balance. Thromb Diath Haemorrh. 1958 Sep 1;2(3-4):347–357. [PubMed] [Google Scholar]
  2. Baker I. A., Eastham R., Elwood P. C., Etherington M., O'Brien J. R., Sweetnam P. M. Haemostatic factors associated with ischaemic heart disease in men aged 45 to 64 years. The Speedwell study. Br Heart J. 1982 May;47(5):490–494. doi: 10.1136/hrt.47.5.490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Douglas J. T., Blamey S. L., Lowe G. D., Carter D. C., Forbes C. D. Plasma beta-thromboglobulin, fibrinopeptide A and B beta 15-42 antigen in relation to postoperative DVT, malignancy and stanozolol treatment. Thromb Haemost. 1985 Apr 22;53(2):235–238. [PubMed] [Google Scholar]
  4. Douglas J. T., Lowe G. D., Forbes C. D., Prentice C. R. Plasma fibrinopeptide A and beta-thromboglobulin in patients with chest pain. Thromb Haemost. 1983 Aug 30;50(2):541–542. [PubMed] [Google Scholar]
  5. Haines A. P., Howarth D., North W. R., Goldenberg E., Stirling Y., Meade T. W., Raftery E. B., Millar Craig M. W. Haemostatic variables and the outcome of myocardial infarction. Thromb Haemost. 1983 Dec 30;50(4):800–803. [PubMed] [Google Scholar]
  6. Hamsten A., Blombäck M., Wiman B., Svensson J., Szamosi A., de Faire U., Mettinger L. Haemostatic function in myocardial infarction. Br Heart J. 1986 Jan;55(1):58–66. doi: 10.1136/hrt.55.1.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hamsten A., Wiman B., de Faire U., Blombäck M. Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N Engl J Med. 1985 Dec 19;313(25):1557–1563. doi: 10.1056/NEJM198512193132501. [DOI] [PubMed] [Google Scholar]
  8. Judkins M. P. Selective coronary arteriography. I. A percutaneous transfemoral technic. Radiology. 1967 Nov;89(5):815–824. doi: 10.1148/89.5.815. [DOI] [PubMed] [Google Scholar]
  9. Khanna P. K., Seth H. N., Balasubramanian V., Hoon R. S. Effect of submaximal exercise on fibrinolytic activity in ischaemic heart disease. Br Heart J. 1975 Dec;37(12):1273–1276. doi: 10.1136/hrt.37.12.1273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lane D. A., Wolff S., Ireland H., Gawel M., Foadi M. Activation of coagulation and fibrinolytic systems following stroke. Br J Haematol. 1983 Apr;53(4):655–658. doi: 10.1111/j.1365-2141.1983.tb07316.x. [DOI] [PubMed] [Google Scholar]
  11. Meade T. W., Mellows S., Brozovic M., Miller G. J., Chakrabarti R. R., North W. R., Haines A. P., Stirling Y., Imeson J. D., Thompson S. G. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet. 1986 Sep 6;2(8506):533–537. doi: 10.1016/s0140-6736(86)90111-x. [DOI] [PubMed] [Google Scholar]
  12. Meade T. W., North W. R., Chakrabarti R., Stirling Y., Haines A. P., Thompson S. G., Brozovié M. Haemostatic function and cardiovascular death: early results of a prospective study. Lancet. 1980 May 17;1(8177):1050–1054. doi: 10.1016/s0140-6736(80)91498-1. [DOI] [PubMed] [Google Scholar]
  13. Neri Serneri G. G., Gensini G. F., Abbate R., Mugnaini C., Favilla S., Brunelli C., Chierchia S., Parodi O. Increased fibrinopeptide A formation and thromboxane A2 production in patients with ischemic heart disease: relationships to coronary pathoanatomy, risk factors, and clinical manifestations. Am Heart J. 1981 Feb;101(2):185–194. doi: 10.1016/0002-8703(81)90665-7. [DOI] [PubMed] [Google Scholar]
  14. Nichols A. B., Owen J., Kaplan K. L., Sciacca R. R., Cannon P. J., Nossel H. L. Fibrinopeptide A, platelet factor 4, and beta-thromboglobulin levels in coronary heart disease. Blood. 1982 Sep;60(3):650–654. [PubMed] [Google Scholar]
  15. Nossel H. L. Relative proteolysis of the fibrinogen B beta chain by thrombin and plasmin as a determinant of thrombosis. Nature. 1981 May 14;291(5811):165–167. doi: 10.1038/291165a0. [DOI] [PubMed] [Google Scholar]
  16. Paramo J. A., Colucci M., Collen D., van de Werf F. Plasminogen activator inhibitor in the blood of patients with coronary artery disease. Br Med J (Clin Res Ed) 1985 Aug 31;291(6495):573–574. doi: 10.1136/bmj.291.6495.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stone M. C., Thorp J. M. Plasma fibrinogen--a major coronary risk factor. J R Coll Gen Pract. 1985 Dec;35(281):565–569. [PMC free article] [PubMed] [Google Scholar]
  18. Truswell A. S. ABC of nutrition. Obesity: diagnosis and risks. Br Med J (Clin Res Ed) 1985 Sep 7;291(6496):655–657. doi: 10.1136/bmj.291.6496.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Walker I. D., Davidson J. F., Hutton I., Lawrie T. D. Disordered "fibrinolytic potential" in coronary heart disease. Thromb Res. 1977 Mar;10(3):509–520. doi: 10.1016/0049-3848(77)90160-8. [DOI] [PubMed] [Google Scholar]
  20. Wilhelmsen L., Svärdsudd K., Korsan-Bengtsen K., Larsson B., Welin L., Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med. 1984 Aug 23;311(8):501–505. doi: 10.1056/NEJM198408233110804. [DOI] [PubMed] [Google Scholar]
  21. Yarnell J. W., Sweetnam P. M., Elwood P. C., Eastham R., Gilmour R. A., O'Brien J. R., Etherington M. D. Haemostatic factors and ischaemic heart disease. The Caerphilly study. Br Heart J. 1985 May;53(5):483–487. doi: 10.1136/hrt.53.5.483. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES