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. 1989 Jun;61(6):506–509. doi: 10.1136/hrt.61.6.506

Central haemodynamic changes after a meal.

H Kelbaek 1, O Munck 1, N J Christensen 1, J Godtfredsen 1
PMCID: PMC1216707  PMID: 2757863

Abstract

Eight healthy people (seven men and one woman, aged 19 to 31 years) were studied by radionuclide cardiography when supine before and 30 minutes after a standard meal (6300 kJ). Control investigations were performed on a different day within a week of the standard meal. There was a median increase in cardiac output of 62% that was attributable to a 17% increase in heart rate and a 41% increase in stroke volume. Blood pressure and concentrations of plasma catecholamines did not change. The median end diastolic and end systolic volumes of the left ventricle increased by 41% so that the left ventricular ejection fraction was unchanged. There were no significant changes during the control experiments. In healthy people a meal caused an appreciable increase in stroke volume and dilatation of the left ventricle. The activity of the sympathetic nervous system, as measured by plasma catecholamines, did not change much, and changes in blood volume alone did not seem to explain the haemodynamic response to the meal.

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Selected References

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  1. Bloom S. R., Edwards A. V., Hardy R. N., Malinowska K., Silver M. Cardiovascular and endocrine responses to feeding in the young calf. J Physiol. 1975 Dec;253(1):135–155. doi: 10.1113/jphysiol.1975.sp011184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown J. M., White C. J., Sobol S. M., Lull R. J. Increased left ventricular ejection fraction after a meal: potential source of error in performance of radionuclide angiography. Am J Cardiol. 1983 Jun;51(10):1709–1711. doi: 10.1016/0002-9149(83)90215-1. [DOI] [PubMed] [Google Scholar]
  3. Chou C. C., Hsieh C. P., Yu Y. M., Kvietys P., Yu L. C., Pittman R., Dabney J. M. Localization of mesenteric hyperemia during digestion in dogs. Am J Physiol. 1976 Mar;230(3):583–589. doi: 10.1152/ajplegacy.1976.230.3.583. [DOI] [PubMed] [Google Scholar]
  4. Christensen N. J., Vestergaard P., Sørensen T., Rafaelsen O. J. Cerebrospinal fluid adrenaline and noradrenaline in depressed patients. Acta Psychiatr Scand. 1980 Feb;61(2):178–182. doi: 10.1111/j.1600-0447.1980.tb00577.x. [DOI] [PubMed] [Google Scholar]
  5. Cornyn J. W., Massie B. M., Unverferth D. V., Leier C. V. Hemodynamic changes after meals and placebo treatment in chronic congestive heart failure. Am J Cardiol. 1986 Feb 1;57(4):238–241. doi: 10.1016/0002-9149(86)90898-2. [DOI] [PubMed] [Google Scholar]
  6. Ehrlich W., Tosheff J., Caldini P., Abbey H., Brady J. V. Adaptation of cardiac output, coronary flow and other circulatory functions in dogs to exercise and to eating. Johns Hopkins Med J. 1972 Apr;130(4):216–234. [PubMed] [Google Scholar]
  7. Frase L. L., Gaffney F. A., Lane L. D., Buckey J. C., Said S. I., Blomqvist C. G., Krejs G. J. Cardiovascular effects of vasoactive intestinal peptide in healthy subjects. Am J Cardiol. 1987 Dec 1;60(16):1356–1361. doi: 10.1016/0002-9149(87)90619-9. [DOI] [PubMed] [Google Scholar]
  8. Fronek K., Stahlgren L. H. Systemic and regional hemodynamic changes during food intake and digestion in nonanesthetized dogs. Circ Res. 1968 Dec;23(6):687–692. doi: 10.1161/01.res.23.6.687. [DOI] [PubMed] [Google Scholar]
  9. Gallavan R. H., Jr, Chou C. C., Kvietys P. R., Sit S. P. Regional blood flow during digestion in the conscious dog. Am J Physiol. 1980 Feb;238(2):H220–H225. doi: 10.1152/ajpheart.1980.238.2.H220. [DOI] [PubMed] [Google Scholar]
  10. Houpt K. A., Baldwin B. A., Houpt T. R., Hills F. Humoral and cardiovascular responses to feeding in pigs. Am J Physiol. 1983 Feb;244(2):R279–R284. doi: 10.1152/ajpregu.1983.244.2.R279. [DOI] [PubMed] [Google Scholar]
  11. JONES W. B., THOMAS H. D., REEVES T. J. CIRCULATORY AND VENTILATORY RESPONSES TO POSTPRANDIAL EXERCISE. Am Heart J. 1965 May;69:668–676. doi: 10.1016/0002-8703(65)90249-8. [DOI] [PubMed] [Google Scholar]
  12. Kelbaek H., Gjørup T., Brynjolf I., Christensen N. J., Godtfredsen J. Acute effects of alcohol on left ventricular function in healthy subjects at rest and during upright exercise. Am J Cardiol. 1985 Jan 1;55(1):164–167. doi: 10.1016/0002-9149(85)90320-0. [DOI] [PubMed] [Google Scholar]
  13. Kelbaek H., Gjørup T., Fogh J. In vivo stability of in vitro labelled 99Tcm-red blood cells for radionuclide determination of left ventricular ejection fractions and volumes. Nucl Med Commun. 1986 Jul;7(7):541–547. doi: 10.1097/00006231-198607000-00008. [DOI] [PubMed] [Google Scholar]
  14. Kelbaek H., Hartling O. J., Skagen K., Munck O., Henriksen O., Godtfredsen J. First-pass radionuclide determination of cardiac output: an improved gamma camera method. J Nucl Med. 1987 Aug;28(8):1330–1334. [PubMed] [Google Scholar]
  15. Landsberg L., Young J. B. Fasting, feeding and regulation of the sympathetic nervous system. N Engl J Med. 1978 Jun 8;298(23):1295–1301. doi: 10.1056/NEJM197806082982306. [DOI] [PubMed] [Google Scholar]
  16. Vatner S. F., Patrick T. A., Higgins C. B., Franklin D. Regional circulatory adjustments to eating and digestion in conscious unrestrained primates. J Appl Physiol. 1974 May;36(5):524–529. doi: 10.1152/jappl.1974.36.5.524. [DOI] [PubMed] [Google Scholar]
  17. Young J. B., Rowe J. W., Pallotta J. A., Sparrow D., Landsberg L. Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjects. Metabolism. 1980 Jun;29(6):532–539. doi: 10.1016/0026-0495(80)90078-5. [DOI] [PubMed] [Google Scholar]

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