Skip to main content
British Heart Journal logoLink to British Heart Journal
. 1989 Jul;62(1):61–64. doi: 10.1136/hrt.62.1.61

Findings at necropsy in the heart of a patient with anticardiolipin syndrome.

J J Murphy 1, I H Leach 1
PMCID: PMC1216732  PMID: 2757875

Abstract

A 40 year old man with a history of myocardial infarction and hypertension presented with transient cerebral ischaemic attacks, aortic regurgitation, a raised erythrocyte sedimentation rate, and thrombocytopenia. The anticardiolipin syndrome was diagnosed and he was treated with prednisolone and warfarin. He died two years later after the development of acute heart failure. At necropsy his heart showed widespread arteriolar thrombosis without vasculitis, recanalised large vessel occlusion, and a "post-inflammatory" valvulitis of the aortic valve.

Full text

PDF
61

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alarcón-Segovia D. Pathogenetic potential of antiphospholipid antibodies. J Rheumatol. 1988 Jun;15(6):890–893. [PubMed] [Google Scholar]
  2. Ansari A., Larson P. H., Bates H. D. Cardiovascular manifestations of systemic lupus erythematosus: current perspective. Prog Cardiovasc Dis. 1985 May-Jun;27(6):421–434. doi: 10.1016/0033-0620(85)90003-9. [DOI] [PubMed] [Google Scholar]
  3. Asherson R. A., Harris E. N. Anticardiolipin antibodies--clinical associations. Postgrad Med J. 1986 Dec;62(734):1081–1087. doi: 10.1136/pgmj.62.734.1081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Asherson R. A., Mackay I. R., Harris E. N. Myocardial infarction in a young man with systemic lupus erythematosus, deep vein thrombosis, and antibodies to phospholipid. Br Heart J. 1986 Aug;56(2):190–193. doi: 10.1136/hrt.56.2.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Coppock M. A., Safford R. E., Danielson G. K. Intracardiac thrombosis, phospholipid antibodies, and two-chambered right ventricle. Br Heart J. 1988 Nov;60(5):455–458. doi: 10.1136/hrt.60.5.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harris E. N., Gharavi A. E., Patel S. P., Hughes G. R. Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol. 1987 Apr;68(1):215–222. [PMC free article] [PubMed] [Google Scholar]
  7. Hughes G. R., Harris N. N., Gharavi A. E. The anticardiolipin syndrome. J Rheumatol. 1986 Jun;13(3):486–489. [PubMed] [Google Scholar]
  8. Hughes G. R. The Prosser-White oration 1983. Connective tissue disease and the skin. Clin Exp Dermatol. 1984 Nov;9(6):535–544. doi: 10.1111/j.1365-2230.1984.tb00856.x. [DOI] [PubMed] [Google Scholar]
  9. Loizou S., McCrea J. D., Rudge A. C., Reynolds R., Boyle C. C., Harris E. N. Measurement of anti-cardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol. 1985 Dec;62(3):738–745. [PMC free article] [PubMed] [Google Scholar]
  10. Morton K. E., Gavaghan T. P., Krilis S. A., Daggard G. E., Baron D. W., Hickie J. B., Chesterman C. N. Coronary artery bypass graft failure--an autoimmune phenomenon? Lancet. 1986 Dec 13;2(8520):1353–1357. doi: 10.1016/s0140-6736(86)92004-0. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES