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. 1996 Dec 1;320(Pt 2):359–363. doi: 10.1042/bj3200359

Two differentially expressed interleukin-11 receptor genes in the mouse genome.

P Bilinski 1, M A Hall 1, H Neuhaus 1, C Gissel 1, J K Heath 1, A Gossler 1
PMCID: PMC1217939  PMID: 8973540

Abstract

Interleukin-11 (IL-11) is a multifunctional cytokine involved in the regulation of cell proliferation and differentiation in a variety of cell types and tissues in vitro and in vivo. The effects of IL-11 were shown to be mediated by the IL-11 receptor (hereafter referred to as IL-11 R alpha), which is a ligand-binding subunit and provides ligand specificity in a functional multimeric signal-transduction complex with gp130. Here we show that the mouse genome contains a second gene encoding an IL-11-binding protein, referred to as IL-11R beta. The structure of the IL-11R beta gene is highly similar to that of IL-11R alpha, and IL-11R beta exhibits 99% sequence identity with IL-11R alpha at the amino acid level. IL-11R beta is co-expressed with IL-11R alpha, albeit at lower levels, in embryos and in various adult tissues. IL-11R beta transcripts are abundant in testis, and, in contrast with IL-11R alpha, absent from skeletal muscle. IL-11R beta expressed in vitro binds IL-11 with high affinity, suggesting that the mouse genome contains a second functional IL-11R.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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