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. 1997 Feb 15;322(Pt 1):19–23. doi: 10.1042/bj3220019

Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.

J M Chandler 1, E S Alnemri 1, G M Cohen 1, M MacFarlane 1
PMCID: PMC1218152  PMID: 9078237

Abstract

DNA-damaging agents induce apoptosis primarily by a p53-dependent pathway. LTR6 cells containing a temperature-sensitive p53 were used to dissect further the mechanisms of p53-induced apoptosis. Apoptosis was accompanied by the processing and activation of CPP32 and Mch3 alpha, together with the cleavage of poly(ADP-ribose) polymerase and lamin B1. These results demonstrate a critical role for the activation of interleukin-1 beta-converting enzyme-like proteases in p53-induced apoptosis.

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Selected References

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