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. 2025 Jun 20;77(4):127. doi: 10.1007/s10616-025-00771-1

Correction: Protective effects of lidocaine on polycystic ovary syndrome through modulating ovarian granulosa cell physiology via PI3K/AKT/mTOR pathway

Haixia Xiong 1,#, Qiong Hu 2,#, Qun Jiang 3,✉
PMCID: PMC12181593  PMID: 40546920

Correction to: Cytotechnology (2022) 74:283–292 10.1007/s10616-022-00528-0

In this article, Figs. 1B and Fig. 4B appeared incorrectly and have now been corrected in the original publication. For completeness and transparency, the correct and old incorrect versions are displayed below.

The original article has been corrected.

Incorrect version:

Fig. 1.

Fig. 1

Lidocaine inhibits the proliferation and induces the apoptosis of the human ovarian granulosa cell-like cell line, KGN. KGN cells were treated with 0, 1, 5 or 10 mM lidocaine for 48 h. A MTT assay was used to measure cell proliferation. B and C Flow cytometry was performed to determine cell apoptosis (Upper left quadrant: necrotic cells; Lower left quadrant: viable cells; Upper right quadrant: late apoptosis; Lower right quadrant: early apoptosis). D Western blotting was used to analyze the protein expression levels of cleaved caspase-3, caspase-3, Bax and Bcl-2. E Ratio of cleaved caspase-3/caspase-3. F and G mRNA expression levels of Bax and Bcl-2 were analyzed using reverse transcription-quantitative PCR. *P < 0.05, **P < 0.01 vs. 0 mM lidocaine group

Correct version (Fig. 1):

graphic file with name 10616_2025_771_Fig1_HTML.jpg

Incorrect version:

Fig. 4.

Fig. 4

PI3K/AKT agonist IGF-1 reverses the effects of lidocaine on KGN human ovarian granulosa cell-like cells. KGN cells were treated with 10 mM lidocaine + 10 μM IGF-1, 10 mM lidocaine + vehicle or 10 mM lidocaine for 48 h. A MTT assay was performed to measure cell proliferation. B and C Flow cytometry was performed to determine the levels of cell apoptosis (Upper left quadrant: necrotic cells; Lower left quadrant: viable cells; Upper right quadrant: late apoptosis; Lower right quadrant: early apoptosis). D Western blotting was used to analyze the protein expression levels of cleaved caspase-3, caspase-3, Bax and Bcl-2. E Ratio of cleaved caspase-3/caspase-3. F and G mRNA expression levels of Bax and Bcl-2 were measured using reverse transcriptionquantitative PCR. **P < 0.01 vs. control; ##P < 0.01 vs. lidocaine + vehicle. IGF-1, insulin-like growth factor 1

Correct version (Fig. 4):

graphic file with name 10616_2025_771_Fig4_HTML.jpg

Footnotes

Publisher's Note

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Haixia Xiong and Qiong Hu have equal contributors.


Articles from Cytotechnology are provided here courtesy of Springer Science+Business Media B.V.

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