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. 1998 Mar 1;330(Pt 2):599–603. doi: 10.1042/bj3300599

Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes.

D Thomas 1, H Y Kim 1, R Morgan 1, M R Hanley 1
PMCID: PMC1219178  PMID: 9480863

Abstract

Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.

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Selected References

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