Abstract
Twenty-one patients with disseminated malignant melanoma were treated with a combination of carboplatin and cytosine arabinoside. Two complete and three partial remissions occurred. No complete cross-resistance was found with a regimen containing 5-(dimethyltriazeno)imidazole-4-carboxamide (DTIC) in two patients. It is suggested that this regimen might be studied further as a second-line treatment for patients who fail on DTIC-containing treatment.
Key words: Malignant melanoma, Chemotherapy
Abbreviations used
- DTIC
5-(dimethyltriazeno)imidazole-4-carboxamide
- AraC
cytosine arabinoside
References
- Bajetta E, Verusio C, Bonfante V, Bonadonna G (1986) Cytarabine and cisplatin in advanced malignant melanoma. Cancer Treat Rep 70:1441–1442 [PubMed] [Google Scholar]
- Berek JS, Knox R (1987) Intraperitoneal cytosine arabinoside given prior to or with cisplatin results in synergy of survival in a murine ovarian carcinoma mode. Proc Soc Gynecol Invest 34:207 [Google Scholar]
- Bergerat JP, Drewinko B, Corry P, Barlogie B, Ho DH (1981) Synergistic lethal effect ofcis-dichlorodiammineplatinum and 1-β-d-arabinofuranosylcytosine. Cancer Res 41:25–30 [PubMed] [Google Scholar]
- Davidson JP, Faber PJ, Fisher RG, Mansy S, Peresie HJ, Rosenberg B, Van Camp L (1975) Platinum-pyrimidine blue and related complexes: a new class of potent anti-tumor agents. Cancer Chemother Rep 59:287–290 [PubMed] [Google Scholar]
- Evans LM, Casper ES, Rosenbluth R (1987) Phase II trial of carboplatin in advanced malignant melanoma. Cancer Treat Rep 71:171–172 [PubMed] [Google Scholar]
- Glover D, Glick JH, Weiler C, Fox K, Guerry D (1987) WR 2721 and high dose cisplatin: an active combination in the treatment of metastatic melanoma. J Clin Oncol 5:574–578 [DOI] [PubMed] [Google Scholar]
- Howell SB, Gill S (1986) Lack of synergy between cisplatin and cytarabine against ovarian carcinoma in vitro. Cancer Treat Rep 70:409–410 [PubMed] [Google Scholar]
- Kern DH, Morgan CR, Hildebrand-Zanki SU (1988) In vitro pharmacodynamics of 1-β-d-arabinofuranosylcytosine: synergy of antitumor activity withcis-diamminedichloroplatinum (II). Cancer Res 48:117–121 [PubMed] [Google Scholar]
- Luce JK (1972) Chemotherapy of malignant melanoma. Cancer 30:1604–1615 [DOI] [PubMed] [Google Scholar]
- Mulder NH, Sleijfer DTh, de Vries EGE, Schraffordt Koops H, Samson MJ, Willemse PHB (1989) Phase II study of bleomycin, dacarbazine (DTIC) and vindesine in disseminated malignant melanoma. J Cancer Res Clin Oncol 115:93–95 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Prooijen R, v. d. Kleyn E, Haanen C (1977) Pharmacokinetics of cytosine arabinoside in acute leukemia. Clin Pharmacol Ther 21:744–750 [DOI] [PubMed] [Google Scholar]
- WHO (1979) Handbook for reporting results of cancer treatment. WHO Offset Publication no. 48, Nijhoff, The Hague [Google Scholar]