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Journal of Cancer Research and Clinical Oncology logoLink to Journal of Cancer Research and Clinical Oncology
. 1992 Jan;118(1):67–71. doi: 10.1007/BF01192314

Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer

Dennis Nowak 1, Andreas Meyer 1, Ute Schmidt-Preuss 2, Ulrich Gatzemeier 1, Helgo Magnussen 1, Hugo W Rüdiger 2,✉
PMCID: PMC12200083  PMID: 1309533

Abstract

The in vitro formation of benzo[a]pyrene-DNA adducts was determined in peripheral blood monocytes of 22 lung cancer patients with at least one first-degree relative with lung cancer and compared to results obtained in 30 healthy controls. In patients, the mean (SEM) adduct formation was 2.8 (0.3) fmol/μg DNA as compared to 2.1 (0.1) fmol/μg in controls (p<0.05), and it was independent of age and smoking habits. These findings support the hypothesis that carcinogen-DNA adduct formation may be one factor of a constitutionally enhanced lung cancer risk.

Key words: Lung cancer; Genetic predisposition; Familial cancer; Benzo[a]pyrene, DNA adducts

Footnotes

This work was supported by a grant from the German Minister for Research and Technology, BMFT

Definition: Pack-year, 1 packet of cigarettes/day x no. years they were smoked

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