Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

Bridget T Hill; L K Hosking; S McClean; S A Shellard; W C M Dempke; R D H Whelan; M Sehested; E Friche; E J F Demant; P B Jensen; B P Kopnin; B Wolf; A Seidel; M Nickelsen; I Brandt; G Heinemann; M Dietel; S Bremer; T Hoof; B Tümmler; H J Broxterman; C H M Versantvoort; C M Kuiper; N Feller; G J Schuurhuis; J Lankelma; S Gupta; T Tsuruo; C Kim; S Gollapudi; A Bittl; M Nap; W Jäger; B Lathan; N Lang; N T Raikhlin; A G Perevozchikov; J L Volodina; T Licht; H H Fiebig; K J Bross; F Herrmann; R Mertelsmann; I Bashir; K Sikora; C S Foster; M Castagna; P Viacava; M Cianfrigliao; A Favati; P Collecchi; M A Caligo; G Cipollini; G Bevilacqua; D Schrenk; T W Gant; J A Silverman; S S Thorgeirsson; A Harstrick; Z G Zhang; H J Schmoll; Y Rustum; M Mitze; T Beck; W Weikel; C Brumm; P G Knapstein; T McDonald; P Gardner; N Kang; S A M van der Heyden; H J Elst; U Stein; B Jandrig; H Krause; P Schmidt-Peter; J Frege; V Wunderlich; E Boven; C K van Kalken; H M Pinedo; W Gebauer; E Fallgren-Gebauer; M Diete; T Wagner; M R Müller; K Lennartz; H R Nowrousian; S Seeber; A A Shtil; A R Kazarov; A V Gudkov; A A Stavrovskaya; F H Djuraeva; T P Stromskaya; A Noller; G Frese; M Neumann; A Wilisch; H Probst

doi:10.1007/BF01635345

. 1991 May;117(Suppl 3):S89–S120. doi: 10.1007/BF01635345

Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

Bridget T Hill ¹, L K Hosking ¹, S McClean ¹, S A Shellard ¹, W C M Dempke ^1,², R D H Whelan ¹, M Sehested ^3,⁴, E Friche ^3,⁴, E J F Demant ^3,⁴, P B Jensen ³, B P Kopnin ^5,⁶, B Wolf ⁷, A Seidel ^8,^9,^10,¹¹, M Nickelsen ^8,⁹, I Brandt ⁸, G Heinemann ⁸, M Dietel ^8,^9,^12,^13,^14,^15,^16,^10,^17,^18,^19,^20,^21,^22,²³, S Bremer ²⁴, T Hoof ²⁴, B Tümmler ²⁴, H J Broxterman ^25,^26,²⁷, C H M Versantvoort ²⁵, C M Kuiper ^25,^26,²⁷, N Feller ^25,²⁶, G J Schuurhuis ^25,^26,^28,^29,^30,²⁷, J Lankelma ^25,^26,^28,^29,^30,²⁷, S Gupta ^31,^32,³³, T Tsuruo ^31,^34,^35,³⁶, C Kim ^31,³², S Gollapudi ^31,³², A Bittl ³⁷, M Nap ³⁷, W Jäger ³⁷, B Lathan ³⁷, N Lang ³⁷, N T Raikhlin ⁶, A G Perevozchikov ⁶, J L Volodina ⁶, T Licht ³⁹, H H Fiebig ³⁹, K J Bross ³⁹, F Herrmann ³⁹, R Mertelsmann ³⁹, I Bashir ⁴⁰, K Sikora ^40,⁴¹, C S Foster ⁴⁰, M Castagna ⁴², P Viacava ⁴², M Cianfrigliao ^42,⁴³, A Favati ⁴², P Collecchi ^42,⁴⁴, M A Caligo ⁴², G Cipollini ⁴², G Bevilacqua ⁴², D Schrenk ⁴⁵, T W Gant ⁴⁵, J A Silverman ⁴⁵, S S Thorgeirsson ⁴⁵, A Harstrick ⁴⁶, Z G Zhang ⁴⁷, H J Schmoll ⁴⁶, Y Rustum ⁴⁷, M Mitze ⁴⁸, T Beck ⁴⁸, W Weikel ⁴⁸, C Brumm ⁴⁸, P G Knapstein ⁴⁸, T McDonald ^32,³³, P Gardner ³², N Kang ³², S A M van der Heyden ⁴⁹, H J Elst ⁵⁰, U Stein ⁵¹, B Jandrig ⁵¹, H Krause ⁵¹, P Schmidt-Peter ⁵², J Frege ⁵³, V Wunderlich ⁵¹, E Boven ²⁶, C K van Kalken ^26,²⁷, H M Pinedo ^26,^28,^29,^30,²⁷, W Gebauer ⁵⁴, E Fallgren-Gebauer ^38,^132,¹⁴⁵, M Diete ^38,^132,¹⁴⁵, T Wagner ^38,^132,¹⁴⁵, M R Müller ⁵⁵, K Lennartz ^55,⁵⁶, H R Nowrousian ⁵⁵, S Seeber ⁵⁵, A A Shtil ⁵⁷, A R Kazarov ^38,^132,¹⁴⁵, A V Gudkov ^38,^132,¹⁴⁵, A A Stavrovskaya ⁵⁸, F H Djuraeva ⁵⁸, T P Stromskaya ⁵⁸, A Noller ^59,^60,^61,⁶², G Frese ^59,^60,⁶¹, M Neumann ^59,⁶¹, A Wilisch ^59,^60,^61,⁶², H Probst ^59,^60,^61,⁶², V Gekeler ^59,^60,^61,^62,^63,^64,^65,⁶⁶, R Handgretinger ⁶⁷, H Schmidt ⁶⁸, C P Muller ⁶⁸, R Dopfer ⁶⁷, T Klingebiel ⁶⁷, D Niethammer ⁶⁷, S Weger ⁶¹, H Diddens ^69,⁷⁰, E Daumiller ⁷¹, A Bunge ¹², R Lilischkis ^12,⁷², A Salmassi ¹², M Kopun ^73,⁷⁴, H Scherthan ⁷³, C Granzow ^73,^75,⁷⁴, I Leuschner ¹³, D Schmidt ¹³, H Hoffmann ¹³, D Harms ¹³, G V Scagliotli ⁷⁶, E Leonardo ⁷⁶, S Cappia ⁷⁶, G Esposito ⁷⁷, M Tombesi ^78,⁷⁹, M Cianfriglia ^78,^79,^80,⁸¹, G V Esposito ⁷⁸, N Merendino ⁷⁸, M Viora ⁷⁸, M Caserta ⁸², E Tritarelli ^80,⁸¹, E Rocca ^80,⁸¹, G Boccoli ^80,⁸¹, P Samoggia ^80,⁸¹, C Fossati ^80,⁸¹, U Testa ^80,⁸¹, C Peschle ^80,⁸¹, J L Darling ^35,³⁶, S M Ashmore ^35,³⁶, D C Peterson ^35,³⁶, D G T Thomas ^35,³⁶, R A Kramer ⁸³, R Stanlunas ⁷⁷, T Summerhayes ⁷⁷, T Lion ⁸⁴, R H Shoemaker ⁸⁵, L Wu ⁸⁵, A Smythe ⁸⁵, M R Boyd ⁸⁵, W T Beck ⁸⁶, M K Danks ⁸⁶, J S Wolverton ⁸⁶, M Chen ⁸⁶, B Y Bugg ⁸⁶, D P Suttle ⁸⁶, C V Catapano ⁸⁷, D J Fernandes ⁸⁷, F Gieseler ^14,⁸⁸, F Boege ^14,⁸⁸, R Erttmann ⁸⁹, H Arps ^14,^90,^91,^18,¹⁹, L Zwelling ^14,¹⁵, K Wilms ^14,⁸⁸, H Biersack ⁸⁸, G J L Kaspers ^92,^93,^94,^95,^96,⁹⁷, R Pieters ^92,^93,^94,^95,^96,⁹⁷, E Klumper ^92,^93,^94,⁹⁵, F C de Waal ^92,^93,^96,⁹⁷, E R van Wering ^92,^93,^94,⁹⁵, A J P Veerman ^92,^93,^94,^95,^96,⁹⁷, C A Schmidt ⁹⁸, F Lorenz ⁹⁸, A Schäfer ⁹⁸, A Kirsch ⁹⁸, W Siegert ⁹⁸, D Huhn ⁹⁸, W E Simon ⁹⁹, G Siebert ⁹⁹, M Schneider ^99,², M Oettling ⁹⁹, A Reymann ^44,¹⁰⁰, R Entmann ^38,^132,¹⁴⁵, S Schmidt ^38,^132,¹⁴⁵, C Woermann ^101,¹⁰⁰, C Windmeier ¹⁰, I Herzig ¹⁰, B Schaefer ^17,^10,^18,¹⁹, H J Heidebrecht ¹⁷, H H Wacker ¹⁷, H Künnemann ¹⁰², Th H M van Heijningen ^28,^29,^30,²⁷, M L Slovak ^28,^29,³⁰, J P A Baak ^28,^29,^30,²⁷, K Steidtmann ^18,¹⁹, A -M J Fichtinger-Schepman ^103,¹⁰⁴, B I Hill ^103,¹⁰⁴, K J Scanlon ¹⁰⁵, W J Zeller ¹⁰⁶, G Chen ¹⁰⁶, J A Gietema ¹⁰⁷, E G E de Vries ¹⁰⁷, DTh Sleijfer ¹⁰⁷, P H B Willemse ¹⁰⁷, H J Guchelaar ¹⁰⁷, D R A Uges ¹⁰⁷, P Aulenbacher ¹⁰⁷, R Voegeli ¹⁰⁷, N H Mulder ¹⁰⁷, C Skrezek ¹⁰⁸, H Bertermann ¹⁰⁸, H Eichholtz-Wirth ^109,¹¹⁰, R Born ¹⁰⁹, H Bier ¹¹¹, M Koch ¹¹², G Bernhardt ^112,¹¹³, K Hählen ^94,⁹⁵, H Reile ¹¹³, C H van Zantwijk ^96,⁹⁷, E R van Wering ^96,⁹⁷, T Görögh ²⁰, B Lippert ²⁰, J A Werner ²⁰, J E Eickbohm ²⁰, G H Mickiseh ¹¹⁴, M M Gottesman ^114,¹¹⁵, I Pastan ¹¹⁴, J Hofmann ¹¹⁶, A Wolf ¹¹⁶, M Spitaler ¹¹⁶, G Bock ^116,¹¹⁷, H Grunicke ¹¹⁶, H Ponstingl ^38,^132,¹⁴⁵, I Roth ^38,^132,¹⁴⁵, C Granzow ¹¹⁸, C Dörner ¹¹⁹, R Erttmann ¹¹⁹, G Looft ¹¹⁹, G J Ossenkoppele ²⁷, G L Scheffer ²⁷, G Atassi ¹¹⁸, A Pierre ^38,^132,¹⁴⁵, L Kraus ^38,^132,¹⁴⁵, S Leonce ^38,^132,¹⁴⁵, G Regnier ^38,^132,¹⁴⁵, A Dhainaut ^38,^132,¹⁴⁵, H Ponstingl ^75,¹²⁰, M Stöhr ^75,¹²¹, C Rohlff ^122,¹²³, R I Glazer ¹²², Y S Cho-Chung ¹²³, V Höllt ²¹, M Kouba ²¹, G Vogt ²¹, H Allmeier ²¹, N I Nissen ⁴, S Cros ¹²⁴, N Guilbaud ^38,^132,¹⁴⁵, T Dunn ^38,^132,¹⁴⁵, M Berlion ^38,^132,¹⁴⁵, G Atassi ^38,^132,¹⁴⁵, J P Bizzari ^38,^132,¹⁴⁵, A M Messing ¹²⁵, A Matuschek ¹²⁵, I Mutter ¹²⁵, J C W Kiwit ¹²⁵, L Bastian ¹²⁶, P E Goretzki ¹²⁶, A Frilling ¹²⁶, D Simon ¹²⁶, H D Röher ¹²⁶, A Reichle ⁷⁰, F Altmayr ⁷⁰, J Rastetter ⁷⁰, C Erbil ¹²⁷, G Jaques ¹²⁷, M Maasberg ¹²⁷, K Havemann ¹²⁷, K Häußermann ⁶², H -J Heidebrecht ^38,^132,¹⁴⁵, W Van de Vrie ^128,¹²⁹, E E O Gheuens ¹³⁰, N M C Durante ^128,¹²⁹, E A De Bruijn ¹³⁰, R L Marquet ¹²⁹, A T Van Oosterom ¹³⁰, A M M Eggermont ¹²⁸, M W Stow ¹³¹, S E Vickers ¹³¹, J R Warr ¹³¹, E Roller ^63,^65,¹³³, M Eichelbaum ^63,^65,¹³⁴, B Klumpp ⁶³, J Krause ⁶³, K Schumacher ^63,^65,¹³³, S Hörner ¹³⁵, A Laßmann ¹³⁵, U Traugott ^136,¹³⁵, E Schlick ¹³⁵, D Bürkle ⁶⁵, BW Futscher ¹³⁷, AF List ¹³⁷, WS Dalton ¹³⁷, E Ladda ¹³³, K Bühl ¹³⁴, A Weimer ¹³³, C Eser ¹³⁴, K Hamprecht ¹³³, K P Schalk ¹³³, C Jackisch ¹³⁸, B Brandt ^138,¹³⁹, M Blum ^138,¹⁴⁰, F Louwen ¹³⁸, K Schulz ¹³⁸, J P Hanker ¹³⁸, U Rüther ¹⁴¹, A Schmidt ¹⁴¹, H A G Müller ¹⁴², C Nunnensiek ¹⁴³, H Bader ¹⁴¹, F Eisenberger ¹⁴¹, P Jipp ¹⁴¹, B Niethammer ¹⁴¹, C Muller ¹⁴⁴, V Ling ¹⁴⁴, F Joncourt ¹⁴⁶, S Redmond ^38,^132,¹⁴⁵, M Stöhr ^53,¹⁴⁷, K Buser ^38,^132,¹⁴⁵, M Fey ^38,^132,¹⁴⁵, A Tobler ^38,^132,¹⁴⁵, K Brunner ^38,^132,¹⁴⁵, A Gratwohl ^38,^132,¹⁴⁵, T Cerrry ^38,^132,¹⁴⁵, V Nuessler ¹⁴⁸, R Pelka-Fleischer ^38,^132,¹⁴⁵, C Nerl ^38,^132,¹⁴⁵, B Beckert ^38,^132,¹⁴⁵, W Wilmanns ^38,^132,¹⁴⁵, S Hegewisch-Becker ¹⁴⁹, M Fliegner ¹⁴⁹, A Zander ¹⁴⁹, D K Hossfeld ¹⁴⁹, J Blanz ¹⁵⁰, K Mewes ^150,¹⁵¹, G Ehninger ¹⁵⁰, K -P Zeller ¹⁵¹, H Schuldes ¹⁵², G Herrmann ¹⁵², W Boeckmann ¹⁵², R Schroeder ¹⁵², D Jonas ¹⁵², K -H Zurborn ¹⁵³, H D Bruhn ¹⁵³, L Uharek ¹⁵⁴, B Glass ¹⁵⁴, W Gassmann ¹⁵⁴, H Loeffler ¹⁵⁴, W Mueller-Ruohholtz ¹⁵⁴, W Gassmann ¹⁵⁵, B Glass ¹⁵⁵, L Uharek ¹⁵⁵, H Loeffler ¹⁵⁵, W Mueller-Ruchholtz ¹⁵⁵, K Jaquet ¹⁵⁶, H Kreipe ¹⁵⁶, J Felgner ¹⁵⁶, H J Radzun ^156,⁷², M R Parwaresch ¹⁵⁶, EA Kogan ^157,¹⁵⁸, NN Mazurenko ^157,¹⁵⁸, SM Sekamova ^157,¹⁵⁸, H Wolf ¹⁵⁹, K Röhe ¹⁵⁹, K Wilkens ¹⁵⁹, M Clausen ¹⁵⁹, E Henze ¹⁵⁹, J van der Bosch ¹⁶⁰, S Rüller ¹⁶⁰, M Schlaak ¹⁶⁰, U Köhl ¹⁶¹, D Schwabe ¹⁶¹, E Rohrbach ¹⁶¹, E Montag ¹⁶¹, S Bauer ¹⁶¹, J Cinatl ¹⁶¹, I Cinatl Jr ^161,¹⁶², M Mainke ¹⁶¹, H Geiss ¹⁶¹, B Kornhuber ¹⁶¹, H Juhl ¹⁶³, H Stritzel ^38,^132,¹⁴⁵, H Kalhoff ^38,^132,¹⁴⁵, W Schniegel ^38,^132,¹⁴⁵, T Menke ¹⁶⁴, B Pröbsting ¹⁶⁴, P Schulze-Westhoff ¹⁶⁴, J Boos ¹⁶⁴, J Weidner ¹⁶⁵, N Wedemeyer ¹⁶⁵, K Wiedorn ¹⁶⁵, Y Ueda ¹⁶⁵, S Blasius ¹⁶⁵, P Wuisman ¹⁶⁵, W Böcker ¹⁶⁵, A Roessner ¹⁶⁵, B Dockhorn-Dworniczak ¹⁶⁵, D Ramm ¹⁶⁶, J Knebel ¹⁶⁶, W Sass ^166,¹⁶⁷, M Aufderheide ^166,¹⁶⁷, J Seifert ¹⁶⁶

¹Laboratory of Cellular Chemotherapy, The Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2A 3PX London, UK

³Dept. Pathology, Sundby Hosp., DK-2300 Copenhagen, Denmark

⁵Department of Cytogenetics, All-Union Cancer Research Center, Kashirskoye shosse 24, 115478 Moscow, USSR

⁷AG Medizinische Physik und Elektronenmikroskopie, Institut für Immunbiologie, Stefan-Meier-Str. 8, D-7800 Freiburg, FRG

⁸Institut für Pathologie, Michaelisstraße 11, 2300 Kiel 1,

²⁴Abteilung Biophysikalische Chemie, Zentrum Biochemie II OE 4350, Medizinische Hochschule Hannover, Konstanty Gutschow Str. 8, D-3000 Hannover 61, FRG

⁹Institut für Pathologie, Michaelisstraße 11, 2300 Kiel, FRG

²⁵Dept. of Med. Oncology, Free University Hosp., de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

³¹Division of Basic and Clinical Immunology, University of California, 92717 Irvine, California

³⁴Japanese Foundation for Cancer Research, Tokyo, Japan

³⁷Department of Pathology, Institute of Public Health, Postbus 21020, 8900 JA Leeuwarden, The Netherlands

³⁸Present Address: Department of Obstetrics and Gynecology, University of Erlangen, Universitätsstr. 21-23, D-8520 Erlangen,

⁶All-Union Cancer Research Center, Kashirskoye shosse 24, 115478 Moscow, USSR

³⁹Department of Internal Medicine I, University of Freiburg, D-7800 Freiburg, Germany

⁴⁰Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 OHS London, UK

⁴¹Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 OHS London, UK

⁴²Istituto di Anatomia Patologica, Università di Pisa, via Roma 57, 56100 Pisa, Italia

⁴³Istituto Superiore di Sanità, Roma,

⁴⁴Istituto Nazionale per la Ricerca sul Cancro, Genova,

⁴⁵Laboratory of Experimental Carcinogenesis, National Institutes of Health, National Cancer Institute, 20892 Bethesda, Md. USA

⁴⁶University of Hannover Medical School, FRG

⁴⁷Roswell Park Cancer Institute, Buffalo, New York USA

⁴⁸Department of Gynecology and Obstetrics, University of Mainz, Langenbeckstraße 1, D-6500 Mainz, FRG

³²Div. Basic & Clinical Immunology, University of California, 92717 Irvine, California

³³Department of Medicine, Stanford University School of Medicine, Stanford, California

⁴⁹Lab of Cancer Res & Clin Onc, University of Antwerp, S4 Universiteitsplein 1, 2710 Wilrijk, Belgium

⁵⁰Lab of Cancer Res & Clin Onc, University of Antwerp, S4, Universiteitsplein 1, 2610 Wilrijk, Belgium

⁵¹Departments of Carcinogenesis, Surgery and Pathology, Institute for Cancer Research, O-1115 Berlin, FRG

⁵²Department of Surgery, Institute for Cancer Research, O-1115 Berlin, FRG

⁵³Department of Pathology, Institute for Cancer Research, O-1115 Berlin, FRG

²⁶Department of Medical Oncology, Free University Hospital, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

⁵⁴Present Address: Hämatolog. Labor der Klin.f.Inn.Med., Medizinische Universität Lübeck, Ratzeburger Alle 160, 2400 Lübeck, FRG

⁵⁵Department of Medical Oncology, University of Essen, USA

⁵⁶Institute of Cell Biology, West German Cancer Centre, University of Essen, USA

⁵⁷Present Address: Laboratory of Molecular Genetics, All-Union. Cancer Research Center, 115478 Moscow, USSR

⁵⁸Institute of Carcinogenesis, All-Union Cancer Research Center of AMS USSR, 115478 Moscow, USSR

⁵⁹Physiologisch-chemisches Institut, Universität Tübingen, Hoppe-Seyler-Straβe 4, 7400 Tübingen, Germany

⁶⁰Physiologisch-chemisches Institut, Universität Tübingen, Hoppe-Seyler-Straβe 4, 7400 Tübingen, Germany

⁶⁷Kinderklinik Klinik, Universität Tübingen, Germany

⁶⁸Medizinische Klinik, Universität Tübingen, Germany

⁶¹Physiologisch-chemisches Institut der Universität Tübingen, Hoppe-Seyler-Straβe 4, 7400 Tübingen, Germany

⁶⁹Medizinisches Laserzentrum Lübeck, Germany

⁷¹Städtische Frauenklinik Stuttgart, Germany

¹²Institut für Pathologie, Christian-Albrechts-Universität zu Kiel, Michaelisstraße 11, 2300 Kiel,

⁷³Institut für Zell-und Tumorbiologie, Deutsches Krebsforschungszentrum, INF 280, W-6900 Heidelberg,

¹³Dept. of Pathology, University of Kiel, Michaelisstr. 11, D-2300 Kiel,

⁷⁶Istituio di Anatomia ed Istologia Patologica, Ospedale S. Luigi Gonzaga, Orbassano, Torino

⁷⁹Laboratorio di Immunologia, Istituto Superiors di Sanità, Roma,

⁷⁸Laboratorio di Immunologia, ISS, Roma,

⁸²Centra Studi per gli Acidi Nucleici CNR, Roma,

⁸⁰Laboratorio di Immunologia, ISS, Roma,

⁸¹Laboratorio di Ematologia e Oncologia, ISS, Roma,

³⁵Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, London, UK

³⁶Cancer Chemotherapy Centre, Japanese Foundation for Cancer Research, Tokyo, Japan

⁸³Lederte Laboratories, Oncology Research Section, 10965 Pearl River, NY USA

⁷⁷Dept. of Surgery, New England Deaconess Hospital, 02115 Boston, MA USA

⁸⁴CCRI, Kinderspitalgasse 6, A-1090 Wien, Austria

⁸⁵Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, 21701-1201 Frederick, MD

⁸⁶St. Jude Children's Research Hospital, 38101 Memphis, TN

⁸⁷Bowman Gray School of Medicine, 27103 Winston-Salem, NC

⁸⁹Present Address: Dept. Pediatric Häm. Oncol. Univ. Hospital, Hamburg, FRG

⁹⁰Inst. Pathol. Univ. Hamburg, FRG

¹⁵Inst. Pathol. Univ. Kiel, FRG

¹⁶MD Anderson Cancer Center, Univ. Texas, Houston, USA

¹⁴Dep. Internal Med., Univ. Hospital, Wuerzburg, FRG

⁸⁸Medizinische Poliklinik der Universität Würzburg, Klinikstraße 6-8, 8700 Würzburg,

⁹²Dept of Pediatrics, Free Univ Hospital, De Boelelaan 1117, 1081 HV Amsterdam,

⁹³Dutch Childhood Leukemia Study Group, The Hague, The Netherlands

⁹⁸Innere Medizin m.S. Hämatologie, Freie Universität Berlin, Klinikum Rudolf Virchow, Spandauer Damm 130, 1000 Berlin 19,

⁹⁹Dept. of Obstetrics and Gynecology, University of Tübingen, D-7400 Tübingen,

¹⁰¹Dept of Pharmacology, Institute of Pathology, Dent of Pediatric Oncology, University of Hamburg, Martinistraße 52, D-2000 Hamburg 20,

⁹¹Institute of Pathology, University of Kiel, Michaelisstraße 11, D-2300 Kiel 1, FRG

¹⁰Dept. of Pathology, University of Kiel, Michaelisstr. 11, 2300 Kiel 1, FRG

¹⁷Dept. of Pathology, University of Kiel, Germany

¹⁰²Center of Biology, University of Kiel, Germany

²⁸Departments of Medical Oncology and Pathology, Free University Hospital, de Boelelaan 1117, 1081 HV Amsterdam,

²⁹Netherlands Cancer Institute, The Netherlands

³⁰City of Hope Hospital, Duarte, CA. MLS

¹⁸Institutes of Pathology of the Universities of Hamburg and Kiel, Germany

¹⁹Michaelisstr. 11, D-2300 Kiel, FRG

¹⁰⁵Present Address: Section of Biochemical Pharmacology, Department of Medical Oncology, Montana Building, City of Hope National Medical Center, 91010 Duarte, California

¹⁰³Imperial Cancer Research Fund Labs, PO Box 123, WC2A 3PX London, UK

¹⁰⁴Medical Biological Lab., TNO, 2280 AA Rijswijk, The Netherlands

²Med. Klink IV der RKTH, Pauwelsstr. 30, D-5100 Aachen, FRG

¹⁰⁶Institute of Toxicology and Chemotherapy, German Cancer Research Center, 6900 Heidelberg, FRG

¹⁰⁷Division of Medical Oncology, Department of Internal Medicine, University Hospital, Oostersingel 59, 9713 EZ Groningen, The Netherlands

¹⁰⁸Dep. of Urology, University of Kiel, Arnold-Heller-Str.7, D-2300 Kiel 1, FRG

¹⁰⁹GSF-Institut für Strahlenbiologie, 8042 Neuherberg,

¹¹⁰Strahlenbiologisches Institut der LMU, Schillerstr.42, 8000 München 2,

¹¹¹Dept. of Otorhinolaryngology, Heinrich-Heine-University, Moorenstr., D-4000 Düsseldorf 1, FRG

¹¹²Institut für Pharmazie, SFB 234, Universität Regensburg, Universitätsstr. 31, W-8400 Regensburg, FRG

⁹⁴Dept of Pediatrics, Free Univ Hospital, De Boelelaan 1117, 1081 HV Amsterdam,

⁹⁵Dutch Childhood Leukemia Study Group, The Hague, The Netherlands

¹¹³Institut für Pharmazie, SFB 234, Universität Regensburg, Universitätsstr. 31, W-8400 Regensburg, FRG

⁹⁶Dept of Pediatrics, Free Univ Hospital, De Boelelaan 1117, 1081 HV Amsterdam,

⁹⁷Dutch Childhood Leukemia Study Group, The Hague, The Netherlands

²⁰Dept. of Pathology, University of Kiel, Michaelisstr. 11, 2300 Kiel, FRG

¹¹⁴Labs. of Molecular, USA

¹¹⁵Labs. of Cell Biology, National Cancer Institute, NIH, 20892 Bethesda, MD USA

¹¹⁶Institute of Medical Chemistry and Biochemistry, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria

¹¹⁷Institute of General and Experimental Pathology, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria

¹⁴⁷Projekt Cytometrie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900 Heidelberg,

¹⁰⁰Dept of Pharmacology, University of Hamburg, Martinistraße 52, D-2000 Hamburg 20,

¹¹⁹Dept of Pediatric Oncology, University of Hamburg, Martinistraße 52, D-2000 Hamburg 20,

²²Institute of Pathology, University of Kiel, Michaelisstraße 11, D-23Q0 Kiel 1, FRG

²⁷Departments of Medical Oncology, Quantitative Pathology and Hematology, Free University Hospital, PO Box 7057, 1007 MB Amsterdam, The Netherlands

¹¹⁸Present Address: Division de Cancérologie Expérimentals, Institut de Recherches SERVIER, 11, rue des Moulineaux, 92150 Suresses, France

⁷⁵Institut für Zell- und Tumorbiologie, Deutsches Krebsforschungszentrum, INF 280, W-6900 Heidelberg,

¹²⁰Projekt Molekulare Biologie der Mitose, Deutsches Krebsforschungszentrum, INF 280, W-6900 Heidelberg,

¹²¹Institut für Radiologie und Pathophysiologie, Deutsches Krebsforschungszentrum, INF 280, W-6900 Heidelberg,

¹²³LTIB, National Cancer Institute, NIH 9000 Rockvillc Pk, Bldg 10/Rm 5B38, 20892 Bethcsda, MD USA

¹²²Georgctown University Medical Center, Med/Dent NE 402 Reservoir Rd, 20016 Washington, D.C., USA

²¹Department of Physiology, University of Munich, Pettenkoferstraße 12, 8000 München 2,

²³Department of Pathology, University of Kiel, Germany

⁴Department of Medicine and Hematology, L 4042, Rigshospitalet-University Hospital, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark

¹²⁴Present Address: Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS, 205 route de Narbonne, 31078 Toulouse Cedex, France

¹²⁵Neurosurgical Clinic, University Hospital, Heinrich-Heine-University, Moorenstraße 5, 4000 Düsseldorf, FRG

¹²⁶Dep. of Surgery, Univ. of Düsseldorf, Moorenstr. 5, W-4000 Düsseldorf 1,

⁷⁰Department of Medicine I, Division of Hematology and Oncology Technische, Universität München, IsmaningerStr. 22, D-8000 Munich 80, FRG

¹²⁷Present Address: Department of Internal Medicine Division of Hematology/Oncology, Philipps-University Marburg, Baldingerstrasse, D-3550 Marburg, FRG

⁶²Physiologisch-chemisches Institut, Universität Tübingen, Hoppe-Seyler-Straße 4, 7400 Tübingen, Germany

¹¹Institut für Pathologie, Christian-Albrechts-Universität, Michaelisstr. 11, D-2300 Kiel,

¹²⁸Rotterdam Cancer Center, Dept. Surgical Oncology, University Rotterdam, The Netherlands

¹²⁹Dept. Surgical Erasmus, University Rotterdam, The Netherlands

¹³⁰University of Antwerp, Belgium

¹³²Present Address: Biocode Ltd., University Road, YO1 IDE Heslington, York UK

¹³¹Biology Department, University of York, York YO1 5DD Heslington, UK

⁶³Robert-Bosch KH, D-7000 Stuttgart 50,

⁶⁴Physiologisch-Chemisches Institut, Universität, Tübingen, FRG

¹³⁵Department of Oncology/Immunology, Department of Biochemistry, Knoll AG, Knollstraße, 6700 Ludwigshafen, FRG

⁶⁵Robert-Bosch KH, D-7000 Stuttgart 50,

⁶⁶Physiologisch-Chemisches Institut, Universität Tübingen, FRG

⁷⁴Institut für Zell- und Tumorbiologie, Deutsches Krebsforschungszentrum, INF 280, W-6900 Heidelberg,

¹³⁷Arizona Cancer Center, Bone Marrow Transplant, 1515 North Campbell, 85724 Tuscon, AZ USA

¹³³Department of Hematology, Oncology and Immunologie, Robert-Bosch-Krankenhaus, Stuttgart,

¹³⁴Institute of Clinical Pharmacology, Robert-Bosch-Krankenhaus, Stuttgart,

¹³⁶Fa. Knoll AG, Ludwigshafen,

¹³⁸Department of Gynecology and Obstetrics, University of Münster, Albert-Schweitzer-Straβe 33, D-4400 Münster,

¹⁴⁰Depatment of Surgery, University of Münster, Jungeblodtplatz 1, D-4400 Münster,

¹³⁹Institut of Clinical Chemestry and Laboratory Investigation, University of Münster, Albert-Schweitzer-Straße 33, D-4400 Münster,

¹⁴¹Katharineohospital, Kriegsbergstr. 60, Stuttgart 1,

¹⁴²Klinik am Eichert, Göppingen,

¹⁴³Ärztliche Praxis, Reutlingen, FRG

¹⁴⁵Present Address: Laboratoire de Pharmacologie et Toxicologie Fondamentales (CNRS), Toulouse, France

¹⁴⁴Ontario Cancer Institute, M4X 1K9 Toronto, Ontario Canada

¹⁴⁶Abteilung für klin-exp. Forschung, Universität Bern, Tiefenaustr. 120, 3004 Bern, Switzerland

¹⁴⁸Present Address: Medizinische Klinik III, Klinikum Grosshadern der Ludwig-Maximilians-Universität München, Germany

¹⁴⁹Dep. of Oncology and Haematology, University Clinic of Hamburg, Martinistr. 52, 2000 Hamburg 20, W-Germany

¹⁵⁰Abteilung Innere Medizin II, Medizinische Klinik und Poliklinik, Otfried-Müller-Str. 10, D-7400 Tübingen,

¹⁵¹Institut für Organische Chemie, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 18, D-7400 Tübingen,

¹⁵²Urologische Abteilung, Zentrum der Chirurgie, Universität Frankfurt /M., Theodor-Stern-Kai 7, 6000 Frankfurt am Main 70, Germany

¹⁵³Klinik für Allgemeine Innere Medizin der Christian-Albrechts-Universität, Schittenhelmstr. 12, W-2300 Kiel 1, Germany

¹⁵⁴Dept. of Internal Medicine II, University of Kiel, Chemitzstr. 33, D-2300 Kiel, Germany

¹⁵⁵Dept. of Internal Medicine II, University of Kiel, Chemitzstr. 33, D-2300 Kiel, Germany

¹⁵⁶Institute of Pathology, Michaelisstr. 11, 2300 Kiel, Germany

⁷²Institute of Pathology, Michaelisstr. 11, 2300 Kiel, FRG

¹⁵⁷Department of Pathology, Medical Academy of Moscow, Bolshaj Pirogovskaj 2/6, 119881 Moscow, USSR

¹⁵⁸All-Union Cancer Research Center, Moscow, USSR

¹⁵⁹Present Address: Department of Nuclear Medicine, University of Kiel, Arnold-Heller-Str. 9, D-2300 Kiel 1,

¹⁶⁰Forschungsinstitut Borstel, 2061 Borstel, FRG

¹⁶¹Zentrum der Kinderheilkunde der J.W.Goethe Universität, Theodor Stern Kai 7,

¹⁶²Zentrum der Hygiene, Paul Ehrlichstr.40, 6000 Frankfurt,

¹⁶³Present Address: Chirurgische Universitätsklinia Hamburg, Martinistr. 52, 2000 Hamburg 20, Germany

¹⁶⁴Universitäts-Kinderklinik, Albert-Schweitzer-Str 33, 44 Münster,

¹⁶⁵Gerhard-Domagk-Institut für Pathologie, Domagkstr. 17, D-4400 Münster,

¹⁶⁶Institute of Exp. Pathology, Hannover Medical School, Konstanty-Gutschowstr. 8, 3 Hannover 61,

¹⁶⁷Dept. of Exp. Surgery, University of Kiel, Michaelisstr. 5, 23 Kiel 1,

PMCID: PMC12200088 PMID: 1684183

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Footnotes

Supported in part by the Forschungsförderung des Landes Baden-Württemberg (H. Sch.)

This work was supported by grants from CNR (Progetto Finalizzato Oncologia and Progetto Finalizzato Biotecnologia e Biostrumentazioni) and from Progetto Italia — USA per la lotta contro i tumori.

This work was supported by grants from CNR (Progetto Finalizzato Oncologia and Progetto Finalizzato Biotecnologia e Biostrumentazioni) and from Progetto Italia-USA per la lotta contro i tumori.

Supported by the Jubiläumsfonds der Österreichischen Nationalbank (Proj. Nr. 3558) and the Hochschuljubiläumsstiftung der Stadt Wien

Supported by Wilhelm-Sander Stiftung, grant 90.038.1. and the Deutsche Forschungsgemeinschaft, SFB 172, C9.

Supported by the Robert-Bosch-Foundation, B-859-35 was a gift from Byk Gulden Konstanz, R-verapamil from Knoll AG Ludwigshafen

Supported in pan by the Deutsche Krebshilfe. The authors are grateful to H. Ponstingl for the gift of Napavin.

Supported by Robert-Bosch-Foundation Stuttgart and Knoll AG, Ludwigshafen.

Supported by Kinderhilfestiftung e.V.

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