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. 1993 Nov;119(11):652–656. doi: 10.1007/BF01215983

Establishment and characteristics of two new human mammary carcinoma lines serially transplantable in nude mice

Helga Naundorf 1,✉, Iduna Fichtner 1, Gerd Jörg Saul 2, Wolfgang Haensch 3, Britta Büttner 1
PMCID: PMC12200535  PMID: 8102371

Abstract

Two human mammary carcinomas of postmenopausal women were successfully transplanted into nude mice. Both tumours were classified as epidermal-growth-factor-, oestradiol- and progesterone-receptor-negative and c-erbB2-protein-positive. Histological studies of the primary tumours (4000 and 4151) revealed ductal invasive mammary carcinomas. In the first passages the precondition for the growth of breast carcinoma 4000 were pretreatments of the nude mice with oestradiol and peanut oil before transplantation. The mammary carcinomas 4000 and 4151 described here are suitable for in vivo testing of antineoplastic substances and for biological studies.

Key words: Oestradiol-receptor-negative, c-erbB2 protein-positive, Establishment in nude mice, Human mammary carcinomas

Footnotes

This work was supported by Schering AG Berlin

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