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. 1992 Aug;118(8):615–620. doi: 10.1007/BF01211807

Prognostic factors in WHO grade 2 transitional-cell bladder cancer (TCC); a novel two-grade classification system for TCC based on mitotic index

P K Lipponen 1,✉, M J Eskelinen 2, K Jauhiainen 3, E Harju 4, P Terho 5, H Haapasalo 6
PMCID: PMC12200567  PMID: 1517282

Abstract

A retrospective histological analysis has been carried out on 537 cases of transitional-cell bladder carcinoma, followed-up over a period of 9 years. In the first part of the study WHO grade 2 tumours were analysed and a number of independent factors predictive for survival identified. In a multivariate analysis the T category and M/V index (number of mitotic figures/mm2 neoplastic epithelium) were the most important prognostic factors. In a subsequent analysis of the whole series of 537 cases, overall the M/V index was not as important in predicting survival as the stage of the tumour. However, in superficial tumours (Ta−T1) subsequent analysis showed that the M/V index alone could be used to predict survival.

Key words: Transitional cell, Bladder tumour, Nuclear image analysis, Mitotic index, WHO grade, Papillary status, Clinical stage, Progression, Survival

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