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. 1995 Feb;121(2):98–102. doi: 10.1007/BF01202220

6-amino-6-deoxyascorbic acid induces apoptosis in human tumor cells

M Grdiša 1, M Kralj 1, M Eckert-Maksić 1, Z B Maksić 1, K Pavelić 1
PMCID: PMC12200643  PMID: 7883782

Abstract

6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.

Key words: 6-amino-6-deoxyascorbic acid, Apoptosis Tumor cells

Abbreviations

NH2-ascorbate

6-amino-6-deoxyascorbic acid

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