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. 1999 Mar 15;338(Pt 3):677–680.

Activation of integrin-beta3-associated syk in platelets.

S Sarkar 1, M M Rooney 1, S T Lord 1
PMCID: PMC1220102  PMID: 10051438

Abstract

Published data suggest that the tyrosine kinase syk participates in platelet signalling through the integrin alphaIIbbeta3. Our data show an association of syk and integrin beta3 in immunoprecipitates from unstimulated and stimulated platelets. We detected syk in anti-beta3 precipitates and, conversely, beta3 in anti-syk precipitates. In vitro kinase assays with anti-beta3 precipitates demonstrated that syk activity was enhanced in ADP-stimulated platelets.

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Selected References

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