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Biochemical Journal logoLink to Biochemical Journal
. 1999 Apr 1;339(Pt 1):15–19.

Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.

S Thiel 1, I Behrmann 1, A Timmermann 1, H Dahmen 1, G Müller-Newen 1, F Schaper 1, J Tavernier 1, V Pitard 1, P C Heinrich 1, L Graeve 1
PMCID: PMC1220122  PMID: 10085222

Abstract

Leukaemia inhibitory factor (LIF) signals via a heterodimeric receptor complex comprised of the LIF receptor (LIFR) and the interleukin (IL)-6 signal transducer gp130. Upon binding to its cognate receptor LIF is internalized. In this study, we show that the LIFR is endocytosed independently of gp130. By using a heterochimaeric receptor system we identified a dileucine-based internalization motif within the cytoplasmic domain of the LIFR. Our findings suggest that a heterodimeric LIFR/gp130 complex and homodimeric gp130/gp130 complex are endocytosed via distinct internalization signals.

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Selected References

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