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Journal of Cancer Research and Clinical Oncology logoLink to Journal of Cancer Research and Clinical Oncology
. 1996 Sep;122(9):566–567. doi: 10.1007/BF01213554

Mediastinal infusion of epirubicin and 5-fluorouracil. A complication of totally implantable central venous systems. Report of a case

J M Rodier 1,, L Malbec 3, E Pujade Lauraine 1, L Batel-Copel 1, A Bernadou 1
PMCID: PMC12201224  PMID: 8781572

Abstract

Perforation of the wall of the superior vena cava by a central venous catheter is reported. The resultant inadvertent infusion of 5-fluorouracil and epirubicin caused a severe acute inflammatory reaction in the right-lobe bronchus, mediastinal infiltration and pleural and pericardial effusions. The patient recovered but has residual mild oesophageal dysfunction.

Key words: Central venous catheter, Epirubicin, Extravasation, 5-Fluorouracil

References

  1. Cathcart-Rake WE, Mowery WE (1991) Intrapericardial infusion of 5-fluorouracil. An unusual complication of a Hickman catheter. Cancer 67: 735–737 [DOI] [PubMed] [Google Scholar]
  2. Manheimer F, Aranda CP, Smith RL (1992) Necrotizing pneumonitis caused by 5-fluorouracil infusion. A complication of a Hickman catheter. Cancer 70: 554–556 [DOI] [PubMed] [Google Scholar]

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