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Journal of Cancer Research and Clinical Oncology logoLink to Journal of Cancer Research and Clinical Oncology
. 1997 Dec;123(9):522–526. doi: 10.1007/BF01192208

Signal Transduction and Mechanisms of Cell Death

Sixth Colloquium on Cellular Signal Transduction, 17 January 1997, Heidelberg, Germany

F Marks 1,, P Boukamp 1
PMCID: PMC12201230  PMID: 9341903

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Footnotes

The next colloquium on cellular signal transduction (Signal transduction and transport across cellular membranes) will be held at the Deutsches Krebsforschungszentrum on 16 January 1988

References

  1. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitrochondrial function. Neuron 15: 961–973 [DOI] [PubMed] [Google Scholar]
  2. Bleuel K, Figueroa R, Härle C, Popp S, Vormwald-Dogan V, Boukamp P (1997) Mini review: multistep process of ultraviolet-induced nonmelanoma skin carcinogenesis. Radiation Oncol Invest (in press)
  3. Bonfoco E, Leist M, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1996) Cytoskeletal breakdown and apoptosis elicited by NO-donors in cerebellar granule cells require NMDA-receptor activation. J Neurochem 67: 2484–2493 [DOI] [PubMed] [Google Scholar]
  4. Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M, Walker R, Schulte-Hermann R (1996) Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 17: 1595–1607 [DOI] [PubMed] [Google Scholar]
  5. Cuthbert AP, Trott DA, Ekong RM, Jazzard S, England NL, Themis M, Todd CM, Newbold RF (1995) Construction and characterisation of a highly stable human: rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies. Cytogenet Cell Genet 71: 68–76 [DOI] [PubMed] [Google Scholar]
  6. Daum G, Eisenmann-Tappe I, Fries HW, Troppmair J, Rapp UR (1994) Ins and outs of Raf kinases. Trends Biochem Sci 19: 474–480 [DOI] [PubMed] [Google Scholar]
  7. England NL, Cuthbert AP, Trott DA, Jezzard S, Nobori T, Carson DA, Newbold RF (1996) Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (pl6INK4A). Carcinogenesis 17: 1567–1575 [DOI] [PubMed] [Google Scholar]
  8. Friesen C, Herr I, Krammer PH, Debatin K-M (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med 2: 574–577 [DOI] [PubMed] [Google Scholar]
  9. Gack S, Vallon R, Schaper J, Ruther U, Angel P (1994) Phenotypic alterations infos-transgenic mice correlate with changes in FOS/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem 269: 10363–10369 [PubMed] [Google Scholar]
  10. Gack S, Vallon R, Schmidt J, Grigoriadis A, Tuckermann J, Schenkel J, Weiher H, Wagner EF, Angel P (1995) Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ 6: 759–767 [PubMed] [Google Scholar]
  11. Galle PR, Hofmann WJ, Walczak H, Schaller H, Otto G, Stremmel W, Krammer PH, Runkel L (1995) Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 182: 1223–1230 [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gandarillas A, Watt FM (1995) Changes in expression of members of thefos andjun families andmyc network during terminal differentiation of human keratinocytes. Oncogene 11: 1403–1407 [PubMed] [Google Scholar]
  13. Grasl-Kraupp B, Ruttkay-Nedecky B, Müllauer L, Taper H, Huber W, Bursch W, Schulte-Hermann R (1997) Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression. Hepatology 25: 906–912 [DOI] [PubMed] [Google Scholar]
  14. Härle-Bachor C, Boukamp P (1996) Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci USA 93: 6476–6481 [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Jones PH, Harper S, Watt FM (1995) Stem cell patterning and fate in human epidermis. Cell 80: 83–93 [DOI] [PubMed] [Google Scholar]
  16. Leist M, Single B, Castoldi AF, Kühnle S, Nicotera P (1997a) Intracellular ATP concentration: a switch deciding between apoptosis and necrosis. J Exp Med 185: 1481–1486 [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Leist M, Fava E, Montecucco C, Nicotera P (1997b) Peroxynitrite and NO-donors induce neuronal apoptosis by eliciting autocrine excitotoxicity. Eur J Neurosci 9: 1488–1498 [DOI] [PubMed] [Google Scholar]
  18. Los M, van de Craen M, Penning CL, Schenk H, Westendorp M, Baeuerle PA, Dröge W, Krammer PH, Fiers W, Schulze-Osthoff K (1995) Requirement of an ICE/Ced-3 protease for Fas/APO-1-mediated apoptosis. Nature 371: 81–83 [DOI] [PubMed] [Google Scholar]
  19. Merritt AJ, Potten CS, Watson AJM, Loh DY, Nakayama K, Nakayama K, Hickman JA (1995) differential expression of Bcl-2 in intestinal epithelia: correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci 108: 2261–2271 [DOI] [PubMed] [Google Scholar]
  20. Merritt AJ, Allen TD, Potten CS, Hickman JA (1997) Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation. Oncogene 14: 2759–2766 [DOI] [PubMed] [Google Scholar]
  21. Müller M, Strand S, Hug H, Heinemann E-V, Walczak H, Hofmann WJ, Stremmel W, Krammer PH, Galle PR (1997) Drug-induced apoptosis in hepatoma cells involves activation of p53 and is mediated by the CD95 (APO-1/Fas) receptor/ligand system. J Clin Invest 99: 403–413 [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817–827 [DOI] [PubMed] [Google Scholar]
  23. Pritchard DM, Watson AJM, Potten CS, Jackman AL, Hickman JA (1997) Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc Natl Acad Sci USA 94: 1795–1799 [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Schreiber M, Baumann B, Cotten M, Angel P, Wagner EG (1995) Fos is an essential component of the mammalian UV response. EMBO J 14: 5338–5349 [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Schulte-Hermann R, Bursch W, Grasl-Kraupp B (1995) Active cell death (apoptosis) in liver biology and disease. Prog Liver Dis 13: 1–35 [PubMed] [Google Scholar]
  26. Schulze-Osthoff K, Bauer M, Vogt M, Los M (1996) Involvement of ICE-related and other proteases in Fas-mediated apoptosis. Cell Death Differ 3: 177–184 [PubMed] [Google Scholar]
  27. Strand S, Hofmann WJ, Hug H, Müller M, Otto G, Strand D, Stremmel W, Krammer PH, Galle PR (1996) Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand expressing tumor cells —a mechanism of immune evasion? Nat Med 2: 1361–1366 [DOI] [PubMed] [Google Scholar]
  28. Wang HG, Takayama S, Rapp UR, Reed JC (1996a) Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci USA 93: 7063–7068 [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wang HG, Rapp UR, Reed JC (1996b) Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87: 1–20 [DOI] [PubMed] [Google Scholar]

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