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. 1990 Sep;116(5):525–527. doi: 10.1007/BF01613006

Histocompatibility locus antigens (HLA) in the epidermoid type of lung carcinoma

J Pražák 1,✉, O Měřička 2, J Chytrý 3
PMCID: PMC12201247  PMID: 2229145

Abstract

HLA-A and B antigens were determined in a study of 162 patients (93 epidermoid type, 20 adenocarcinoma, 26 small-cell carcinoma and 23 undifferentiated types) with lung cancer. Differences between antigen frequencies in cancer and control populations were studied by χ2Y analysis or Fisher's exact test. Survival data were analyzed using Cox's model for censored data. Cancer patients had a decreased frequency of the antigen HLA-B40 (χ2Y=14.15,P=0.00018,P c=0.003, relative risk=0.21). Patients with HLA-A10, A 11 and B27 had a shortened mean survival time. Patients with HLA-B12 had a prolonged survival time.

Key words: Carcinoma of lung, Epidermoidal type, HLA antigens, Survival time

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