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. 1993 Aug;119(8):463–469. doi: 10.1007/BF01215926

A possible role for cell proliferation in potassium bromate (KBrO3) carcinogenesis

Takashi Umemura 1,✉, Kimie Sai 1, Atsuya Takagi 1, Ryuichi Hasegawa 1, Yuji Kurokawa 1
PMCID: PMC12201679  PMID: 7685357

Abstract

Accumulation of α2u and induction of cell proliferation were examined in kidneys of rats exposed to KBrO3, KBr or NaBrO3 in their drinking water. Hyaline droplets observed after KBrO3 or NaBrO3 administration to male rats were specifically immunostained for α2u. Increases in cell proliferation were found in the proximal tubules of male rats given KBrO3 or NaBrO3 but not KBr for 2, 4, and 8 weeks. No such change was evident in KBrO3-treated female rats or the distal tubules of any treated animal. The concordance between hyaline droplet accumulation and increased cell turnover suggests that KBrO3- and NaBrO3-induced cell replication in kidneys of male rats may result from α2u nephropathy. Considering the fact that KBrO3 has genotoxic potential involving oxidative stress, we hypothesize that the induced cell proliferation might predominantly play an additive role in its carcinogenesis. Furthermore, the present data, showing similar effects of NaBrO3 on the rat kidney, are of direct significance to its risk assessment.

Key words: KBrO3, KBr, NaBrO3, α2u, Cell proliferation

Abbreviations

PCT

proximal convoluted tubule

PST

proximal straight tubule

Footnotes

This work was supported by a grant-in-aid for cancer research from the Ministry of Health and Welfare, Japan

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