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. 1995 Dec;121(12):746–752. doi: 10.1007/BF01213321

Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma

Isao Okayasu 1,✉, Makoto Saegusa 1, Mutsunori Fujiwara 2, Yoshihito Hara 3, Noel R Rose 4
PMCID: PMC12201691  PMID: 7499446

Abstract

For the analysis of cellular proliferative activity and cell death in thyroid diseases, the Ki-67 labeling index, bcl-2 protein expression and cell death of follicular epithelia by immunohistochemistry and in situ DNA nick-end labeling methods were evaluated in normal thyroid tissues as well as in surgical specimens from cases of Hashimoto's disease (16 cases), focal lymphocytic thyroiditis (13 cases), Graves' disease (15 cases), follicular adenoma (20 cases) and papillary carcinoma (43 cases). Cellular proliferative activity and cell death were both enhanced in cases of thyroiditis, including Hashimoto's disease and focal lymphocytic thyroiditis. Thyroids from patients with follicular adenoma and papillary carcinoma also showed increased cellular proliferative activity and cell death. In addition, predominant high cellularity and partial loss of bcl-2 protein expression in papillary carcinoma suggested that the overgrowth and dedifferentiation were associated with malignancy.

Key words: Thyroiditis, Papillary carcinoma, Cell proliferation, Ki-67, Cell death, Apoptosis bcl-2, Cellularity

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