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. 1992 May;118(5):367–370. doi: 10.1007/BF01294441

Capture of recombinant ricin A chain by a bispecific anti-RTA: anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice

M V Pimm 1,✉, R A Robins 1, R W Baldwin 1
PMCID: PMC12201713  PMID: 1583066

Abstract

A bispecific antibody against carcinoembryonic antigen (CEA) and ricin A chain has been shown to localise in a CEA-producing human tumour xenograft. When labelled recombinant ricin A chain was subsequently injected there was uptake into tumours, indicating that this bispecific antibody can capture or carry toxin into tumour deposits.

Key words: Ricin A chain, Bispecific antibody, CEA, Carcinoma xenograft

Abbreviations

CEA

carcinoembryonic antigen

r-RTA

recombinant ricin toxin A chain

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