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. 1991 Mar;117(2):163–167. doi: 10.1007/BF01613141

Study of the relationship between immunohistologically demonstrated lymphocytes infiltrating human breast carcinomas and patients' survival

Hanns -Olof Wintzer 1, Wolfram Bohle 2, Sabine von Kleist 1,✉
PMCID: PMC12201854  PMID: 1826109

Abstract

Eighty-five breast carcinomas were immunostained for CD3-, CD4-, CD8-, CD16-, CD22-, CD38- and CD57-positive lymphocyte subpopulations. The results were related to follow-up data (median follow-up 46 months) of 74 patients regarding overall survival and 73 patients in respect to disease-free survival. Whereas the number of axillary lymph node metastases (P<0.01) and the hormone receptor status (P<0.01) resulted in significantly different survival curves for overall survival, not one of the lymphocyte subset infiltrats correlated significantly wich overall survival. For disease-free survival, pT stage (P<0.01) and nodal (P<0.01) and hormone receptor status (P<0.05) proved to be prognostically important. However, disease-free survival was not influenced by the infiltration of any lymphocyte subset.

Key words: Lymphocyte subsets, Breast carcinoma, Survival

Footnotes

This work was supported by Deutsche Krebshilfe e.V., Dr.-Mildred-Scheel-Stiftung für Krebsforschung

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