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. 1999 Dec 1;344(Pt 2):293–296.

Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.

N G Milton 1
PMCID: PMC1220643  PMID: 10567208

Abstract

Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.

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Selected References

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