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. 2001 Feb 1;353(Pt 3):441–444. doi: 10.1042/0264-6021:3530441

An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds.

S Raimbault 1, S Dridi 1, F Denjean 1, J Lachuer 1, E Couplan 1, F Bouillaud 1, A Bordas 1, C Duchamp 1, M Taouis 1, D Ricquier 1
PMCID: PMC1221587  PMID: 11171038

Abstract

The cDNA of an uncoupling protein (UCP) homologue was obtained by screening a chicken skeletal-muscle library. The predicted 307-amino-acid sequence of avian UCP (avUCP) is 55, 70, 70 and 46% identical with mammalian UCP1, UCP2 and UCP3 and plant UCP respectively. avUCP mRNA expression is restricted to skeletal muscle and its abundance was increased 1.3-fold in a chicken line showing diet-induced thermogenesis, and 3.6- and 2.6-fold in cold-acclimated and glucagon-treated ducklings developing muscle non-shivering thermogenesis respectively. The present data support the implication of avUCP in avian energy expenditure.

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Selected References

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