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. 2001 Jun 1;356(Pt 2):345–352. doi: 10.1042/0264-6021:3560345

Use of fluorescent Ca2+ dyes with green fluorescent protein and its variants: problems and solutions.

S Bolsover 1, O Ibrahim 1, N O'luanaigh 1, H Williams 1, S Cockcroft 1
PMCID: PMC1221844  PMID: 11368760

Abstract

We have studied the degree to which fluorescent Ca(2+) indicator dyes, and green fluorescent protein and its variants, can be used together. We find that the most commonly used fluorescent protein, enhanced green fluorescent protein (EGFP), seriously contaminates fura 2 signals. We suggest two alternative combinations for which there is no detectable contamination of the Ca(2+) indicator signal by the fluorescent protein. Blue fluorescent protein can be used with the Ca(2+) indicator Fura Red; EGFP can be used with the Ca(2+) indicator X-Rhod 1. The use of these combinations will permit the accurate measurement of Ca(2+) signals in cells transfected with fluorescent proteins.

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Selected References

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