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. 2002 Feb 1;361(Pt 3):629–633. doi: 10.1042/0264-6021:3610629

Induction of Bach1 and ARA70 gene expression at an early stage of adipocyte differentiation of mouse 3T3-L1 cells.

Makoto Nishizuka 1, Tomoko Tsuchiya 1, Tsutomu Nishihara 1, Masayoshi Imagawa 1
PMCID: PMC1222346  PMID: 11802793

Abstract

Using a subtraction method, we have isolated genes that are induced early in the differentiation of mouse 3T3-L1 preadipocyte cells into adipocytes. These include the genes encoding transcription factors and signalling proteins, as well as unknown genes. Bach1, a transcription factor, and ARA70, a cofactor, were rapidly induced during differentiation. The induction of these two genes was observed only in growth-arrested 3T3-L1 cells, and not in proliferating cells. In NIH-3T3 cells, no induction was observed under either set of conditions. These results strongly indicate that Bach1 and ARA70 have valuable roles at the onset of adipocyte differentiation.

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Selected References

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