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. 2003 Feb 15;370(Pt 1):29–34. doi: 10.1042/BJ20021539

Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.

Philippe Soubeyran 1, Ana Barac 1, Iwona Szymkiewicz 1, Ivan Dikic 1
PMCID: PMC1223168  PMID: 12475393

Abstract

The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.

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Selected References

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