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. 2003 May 15;372(Pt 1):15–32. doi: 10.1042/BJ20030121

Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology.

Enrico Garattini 1, Ralf Mendel 1, Maria João Romão 1, Richard Wright 1, Mineko Terao 1
PMCID: PMC1223366  PMID: 12578558

Abstract

The molybdo-flavoenzymes are structurally related proteins that require a molybdopterin cofactor and FAD for their catalytic activity. In mammals, four enzymes are known: xanthine oxidoreductase, aldehyde oxidase and two recently described mouse proteins known as aldehyde oxidase homologue 1 and aldehyde oxidase homologue 2. The present review article summarizes current knowledge on the structure, enzymology, genetics, regulation and pathophysiology of mammalian molybdo-flavoenzymes. Molybdo-flavoenzymes are structurally complex oxidoreductases with an equally complex mechanism of catalysis. Our knowledge has greatly increased due to the recent crystallization of two xanthine oxidoreductases and the determination of the amino acid sequences of many members of the family. The evolution of molybdo-flavoenzymes can now be traced, given the availability of the structures of the corresponding genes in many organisms. The genes coding for molybdo-flavoenzymes are expressed in a cell-specific fashion and are controlled by endogenous and exogenous stimuli. The recent cloning of the genes involved in the biosynthesis of the molybdenum cofactor has increased our knowledge on the assembly of the apo-forms of molybdo-flavoproteins into the corresponding holo-forms. Xanthine oxidoreductase is the key enzyme in the catabolism of purines, although recent data suggest that the physiological function of this enzyme is more complex than previously assumed. The enzyme has been implicated in such diverse pathological situations as organ ischaemia, inflammation and infection. At present, very little is known about the pathophysiological relevance of aldehyde oxidase, aldehyde oxidase homologue 1 and aldehyde oxidase homologue 2, which do not as yet have an accepted endogenous substrate.

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Selected References

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  1. Abadeh S., Killacky J., Benboubetra M., Harrison R. Purification and partial characterization of xanthine oxidase from human milk. Biochim Biophys Acta. 1992 Jul 21;1117(1):25–32. doi: 10.1016/0304-4165(92)90157-p. [DOI] [PubMed] [Google Scholar]
  2. Adachi T., Fukushima T., Usami Y., Hirano K. Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface. Biochem J. 1993 Jan 15;289(Pt 2):523–527. doi: 10.1042/bj2890523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Adams Benjamin, Lowe David J., Smith Andrew T., Scazzocchio Claudio, Demais Stephane, Bray Robert C. Expression of Drosophila melanogaster xanthine dehydrogenase in Aspergillus nidulans and some properties of the recombinant enzyme. Biochem J. 2002 Feb 15;362(Pt 1):223–229. doi: 10.1042/0264-6021:3620223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Adams M. D., Celniker S. E., Holt R. A., Evans C. A., Gocayne J. D., Amanatides P. G., Scherer S. E., Li P. W., Hoskins R. A., Galle R. F. The genome sequence of Drosophila melanogaster. Science. 2000 Mar 24;287(5461):2185–2195. doi: 10.1126/science.287.5461.2185. [DOI] [PubMed] [Google Scholar]
  5. Akaike T., Ando M., Oda T., Doi T., Ijiri S., Araki S., Maeda H. Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J Clin Invest. 1990 Mar;85(3):739–745. doi: 10.1172/JCI114499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Amaya Y., Yamazaki K., Sato M., Noda K., Nishino T., Nishino T. Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin. J Biol Chem. 1990 Aug 25;265(24):14170–14175. [PubMed] [Google Scholar]
  7. Amrani L., Primus J., Glatigny A., Arcangeli L., Scazzocchio C., Finnerty V. Comparison of the sequences of the Aspergillus nidulans hxB and Drosophila melanogaster ma-l genes with nifS from Azotobacter vinelandii suggests a mechanism for the insertion of the terminal sulphur atom in the molybdopterin cofactor. Mol Microbiol. 2000 Oct;38(1):114–125. doi: 10.1046/j.1365-2958.2000.02119.x. [DOI] [PubMed] [Google Scholar]
  8. Battelli M. G., Abbondanza A., Musiani S., Buonamici L., Strocchi P., Tazzari P. L., Gramantieri L., Stirpe F. Determination of xanthine oxidase in human serum by a competitive enzyme-linked immunosorbent assay (ELISA). Clin Chim Acta. 1999 Mar;281(1-2):147–158. doi: 10.1016/s0009-8981(98)00220-4. [DOI] [PubMed] [Google Scholar]
  9. Battelli M. G., Buonamici L., Virgili M., Abbondanza A., Contestabile A. Simulated ischaemia-reperfusion conditions increase xanthine dehydrogenase and oxidase activities in rat brain slices. Neurochem Int. 1998 Jan;32(1):17–21. doi: 10.1016/s0197-0186(97)00052-1. [DOI] [PubMed] [Google Scholar]
  10. Battelli M. G., Musiani S., Valgimigli M., Gramantieri L., Tomassoni F., Bolondi L., Stirpe F. Serum xanthine oxidase in human liver disease. Am J Gastroenterol. 2001 Apr;96(4):1194–1199. doi: 10.1111/j.1572-0241.2001.03700.x. [DOI] [PubMed] [Google Scholar]
  11. Beckman J. S., Parks D. A., Pearson J. D., Marshall P. A., Freeman B. A. A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. Free Radic Biol Med. 1989;6(6):607–615. doi: 10.1016/0891-5849(89)90068-3. [DOI] [PubMed] [Google Scholar]
  12. Beedham C., Critchley D. J., Rance D. J. Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon. Arch Biochem Biophys. 1995 Jun 1;319(2):481–490. doi: 10.1006/abbi.1995.1320. [DOI] [PubMed] [Google Scholar]
  13. Bendotti C., Prosperini E., Kurosaki M., Garattini E., Terao M. Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons. Neuroreport. 1997 Jul 7;8(9-10):2343–2349. doi: 10.1097/00001756-199707070-00048. [DOI] [PubMed] [Google Scholar]
  14. Berger R., Mezey E., Clancy K. P., Harta G., Wright R. M., Repine J. E., Brown R. H., Brownstein M., Patterson D. Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis. Somat Cell Mol Genet. 1995 Mar;21(2):121–131. doi: 10.1007/BF02255787. [DOI] [PubMed] [Google Scholar]
  15. Berglund L., Rasmussen J. T., Andersen M. D., Rasmussen M. S., Petersen T. E. Purification of the bovine xanthine oxidoreductase from milk fat globule membranes and cloning of complementary deoxyribonucleic acid. J Dairy Sci. 1996 Feb;79(2):198–204. doi: 10.3168/jds.S0022-0302(96)76351-8. [DOI] [PubMed] [Google Scholar]
  16. Bittner F., Oreb M., Mendel R. R. ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana. J Biol Chem. 2001 Sep 11;276(44):40381–40384. doi: 10.1074/jbc.C100472200. [DOI] [PubMed] [Google Scholar]
  17. Bittner F., Oreb M., Mendel R. R. ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana. J Biol Chem. 2001 Sep 11;276(44):40381–40384. doi: 10.1074/jbc.C100472200. [DOI] [PubMed] [Google Scholar]
  18. Blattner F. R., Plunkett G., 3rd, Bloch C. A., Perna N. T., Burland V., Riley M., Collado-Vides J., Glasner J. D., Rode C. K., Mayhew G. F. The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453–1462. doi: 10.1126/science.277.5331.1453. [DOI] [PubMed] [Google Scholar]
  19. Bläse M., Bruntner C., Tshisuaka B., Fetzner S., Lingens F. Cloning, expression, and sequence analysis of the three genes encoding quinoline 2-oxidoreductase, a molybdenum-containing hydroxylase from Pseudomonas putida 86. J Biol Chem. 1996 Sep 20;271(38):23068–23079. doi: 10.1074/jbc.271.38.23068. [DOI] [PubMed] [Google Scholar]
  20. Calzi M. L., Raviolo C., Ghibaudi E., de Gioia L., Salmona M., Cazzaniga G., Kurosaki M., Terao M., Garattini E. Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase. J Biol Chem. 1995 Dec 29;270(52):31037–31045. doi: 10.1074/jbc.270.52.31037. [DOI] [PubMed] [Google Scholar]
  21. Cameron G. S., Pence B. C. Effects of multiple applications of tumor promoters and ultraviolet radiation on epidermal proliferation and antioxidant status. J Invest Dermatol. 1992 Aug;99(2):189–192. doi: 10.1111/1523-1747.ep12616819. [DOI] [PubMed] [Google Scholar]
  22. Cantoni L., Rizzardini M., Graziani A., Carugo C., Garattini S. Effects of chlorinated organics on intermediates in the heme pathway and on uroporphyrinogen decarboxylase. Ann N Y Acad Sci. 1987;514:128–140. doi: 10.1111/j.1749-6632.1987.tb48767.x. [DOI] [PubMed] [Google Scholar]
  23. Carpani G., Racchi M., Ghezzi P., Terao M., Garattini E. Purification and characterization of mouse liver xanthine oxidase. Arch Biochem Biophys. 1990 Jun;279(2):237–241. doi: 10.1016/0003-9861(90)90487-j. [DOI] [PubMed] [Google Scholar]
  24. Cazzaniga G., Terao M., Lo Schiavo P., Galbiati F., Segalla F., Seldin M. F., Garattini E. Chromosomal mapping, isolation, and characterization of the mouse xanthine dehydrogenase gene. Genomics. 1994 Sep 15;23(2):390–402. doi: 10.1006/geno.1994.1515. [DOI] [PubMed] [Google Scholar]
  25. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996 Jul;10(9):940–954. [PubMed] [Google Scholar]
  26. Chow C. W., Clark M. P., Rinaldo J. E., Chalkley R. Multiple initiators and C/EBP binding sites are involved in transcription from the TATA-less rat XDH/XO basal promoter. Nucleic Acids Res. 1995 Aug 25;23(16):3132–3140. doi: 10.1093/nar/23.16.3132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Chow C. W., Clark M., Rinaldo J., Chalkley R. Identification of the rat xanthine dehydrogenase/oxidase promoter. Nucleic Acids Res. 1994 May 25;22(10):1846–1854. doi: 10.1093/nar/22.10.1846. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Clark M. P., Chow C. W., Rinaldo J. E., Chalkley R. Correct usage of multiple transcription initiation sites and C/EBP-dependent transcription activation of the rat XDH/XO TATA-less promoter requires downstream elements located in the coding region of the gene. Nucleic Acids Res. 1998 Apr 1;26(7):1801–1806. doi: 10.1093/nar/26.7.1801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Clark M. P., Chow C. W., Rinaldo J. E., Chalkley R. Multiple domains for initiator binding proteins TFII-I and YY-1 are present in the initiator and upstream regions of the rat XDH/XO TATA-less promoter. Nucleic Acids Res. 1998 Jun 1;26(11):2813–2820. doi: 10.1093/nar/26.11.2813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. DICKINSON C. J., SMELLIE J. M. Xanthinuria. Br Med J. 1959 Dec 5;2(5161):1217–1221. doi: 10.1136/bmj.2.5161.1217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Della Corte E., Stirpe F. The regulation of rat-liver xanthine oxidase: Activation by proteolytic enzymes. FEBS Lett. 1968 Dec;2(2):83–84. doi: 10.1016/0014-5793(68)80107-3. [DOI] [PubMed] [Google Scholar]
  32. Demontis S., Kurosaki M., Saccone S., Motta S., Garattini E., Terao M. The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region. Biochim Biophys Acta. 1999 Dec 23;1489(2-3):207–222. doi: 10.1016/s0167-4781(99)00174-8. [DOI] [PubMed] [Google Scholar]
  33. Ding T. L., Benet L. Z. Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. Drug Metab Dispos. 1979 Nov-Dec;7(6):373–377. [PubMed] [Google Scholar]
  34. Dobbek H., Svetlitchnyi V., Gremer L., Huber R., Meyer O. Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster. Science. 2001 Aug 17;293(5533):1281–1285. doi: 10.1126/science.1061500. [DOI] [PubMed] [Google Scholar]
  35. Dobbek Holger, Gremer Lothar, Kiefersauer Reiner, Huber Robert, Meyer Ortwin. Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15971–15976. doi: 10.1073/pnas.212640899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Dublin Arthur B., Hald John K., Wootton-Gorges Sandra L. Isolated sulfite oxidase deficiency: MR imaging features. AJNR Am J Neuroradiol. 2002 Mar;23(3):484–485. [PMC free article] [PubMed] [Google Scholar]
  37. Dudley B. F., Winston G. W. p-nitrosophenol reduction by liver cytosol from ADH-positive and -negative deermice (Peromyscus maniculatus). Arch Biochem Biophys. 1995 Feb 1;316(2):879–885. doi: 10.1006/abbi.1995.1118. [DOI] [PubMed] [Google Scholar]
  38. Dupont G. P., Huecksteadt T. P., Marshall B. C., Ryan U. S., Michael J. R., Hoidal J. R. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J Clin Invest. 1992 Jan;89(1):197–202. doi: 10.1172/JCI115563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Duran M., Beemer F. A., van de Heiden C., Korteland J., de Bree P. K., Brink M., Wadman S. K., Lombeck I. Combined deficiency of xanthine oxidase and sulphite oxidase: a defect of molybdenum metabolism or transport? J Inherit Metab Dis. 1978;1(4):175–178. doi: 10.1007/BF01805591. [DOI] [PubMed] [Google Scholar]
  40. ENGELMAN K., WATTS R. W., KLINENBERG J. R., SJOERDSMA A., SEEGMILLER J. E. CLINICAL, PHYSIOLOGICAL AND BIOCHEMICAL STUDIES OF A PATIENT WITH XANTHINURIA AND PHEOCHROMOCYTOMA. Am J Med. 1964 Dec;37:839–861. doi: 10.1016/0002-9343(64)90128-7. [DOI] [PubMed] [Google Scholar]
  41. Enroth C., Eger B. T., Okamoto K., Nishino T., Nishino T., Pai E. F. Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10723–10728. doi: 10.1073/pnas.97.20.10723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Falciani F., Ghezzi P., Terao M., Cazzaniga G., Garattini E. Interferons induce xanthine dehydrogenase gene expression in L929 cells. Biochem J. 1992 Aug 1;285(Pt 3):1001–1008. doi: 10.1042/bj2851001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Falciani F., Terao M., Goldwurm S., Ronchi A., Gatti A., Minoia C., Li Calzi M., Salmona M., Cazzaniga G., Garattini E. Molybdenum(VI) salts convert the xanthine oxidoreductase apoprotein into the active enzyme in mouse L929 fibroblastic cells. Biochem J. 1994 Feb 15;298(Pt 1):69–77. doi: 10.1042/bj2980069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Fellman V., Raivio K. O. Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res. 1997 May;41(5):599–606. doi: 10.1203/00006450-199705000-00001. [DOI] [PubMed] [Google Scholar]
  45. Feng G., Tintrup H., Kirsch J., Nichol M. C., Kuhse J., Betz H., Sanes J. R. Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science. 1998 Nov 13;282(5392):1321–1324. doi: 10.1126/science.282.5392.1321. [DOI] [PubMed] [Google Scholar]
  46. Frederiks W. M., Bosch K. S., Kooij A. Quantitative in situ analysis of xanthine oxidoreductase activity in rat liver. J Histochem Cytochem. 1995 Jul;43(7):723–726. doi: 10.1177/43.7.7608527. [DOI] [PubMed] [Google Scholar]
  47. Garrett R. M., Johnson J. L., Graf T. N., Feigenbaum A., Rajagopalan K. V. Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6394–6398. doi: 10.1073/pnas.95.11.6394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Ghafourian T., Rashidi M. R. Quantitative study of the structural requirements of phthalazine/quinazoline derivatives for interaction with human liver aldehyde oxidase. Chem Pharm Bull (Tokyo) 2001 Sep;49(9):1066–1071. doi: 10.1248/cpb.49.1066. [DOI] [PubMed] [Google Scholar]
  49. Ghezzi P., Bianchi M., Mantovani A., Spreafico F., Salmona M. Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers. Biochem Biophys Res Commun. 1984 Feb 29;119(1):144–149. doi: 10.1016/0006-291x(84)91630-9. [DOI] [PubMed] [Google Scholar]
  50. Glatigny A., Hof P., Romão M. J., Huber R., Scazzocchio C. Altered specificity mutations define residues essential for substrate positioning in xanthine dehydrogenase. J Mol Biol. 1998 May 1;278(2):431–438. doi: 10.1006/jmbi.1998.1707. [DOI] [PubMed] [Google Scholar]
  51. Glatigny A., Scazzocchio C. Cloning and molecular characterization of hxA, the gene coding for the xanthine dehydrogenase (purine hydroxylase I) of Aspergillus nidulans. J Biol Chem. 1995 Feb 24;270(8):3534–3550. doi: 10.1074/jbc.270.8.3534. [DOI] [PubMed] [Google Scholar]
  52. Granger D. N., McCord J. M., Parks D. A., Hollwarth M. E. Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine. Gastroenterology. 1986 Jan;90(1):80–84. doi: 10.1016/0016-5085(86)90078-8. [DOI] [PubMed] [Google Scholar]
  53. Granger D. N., Rutili G., McCord J. M. Superoxide radicals in feline intestinal ischemia. Gastroenterology. 1981 Jul;81(1):22–29. [PubMed] [Google Scholar]
  54. Gray T. A., Nicholls R. D. Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. RNA. 2000 Jul;6(7):928–936. doi: 10.1017/s1355838200000182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Hadano S., Hand C. K., Osuga H., Yanagisawa Y., Otomo A., Devon R. S., Miyamoto N., Showguchi-Miyata J., Okada Y., Singaraja R. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet. 2001 Oct;29(2):166–173. doi: 10.1038/ng1001-166. [DOI] [PubMed] [Google Scholar]
  56. Harris C. M., Massey V. The oxidative half-reaction of xanthine dehydrogenase with NAD; reaction kinetics and steady-state mechanism. J Biol Chem. 1997 Nov 7;272(45):28335–28341. doi: 10.1074/jbc.272.45.28335. [DOI] [PubMed] [Google Scholar]
  57. Harris C. M., Sanders S. A., Massey V. Role of the flavin midpoint potential and NAD binding in determining NAD versus oxygen reactivity of xanthine oxidoreductase. J Biol Chem. 1999 Feb 19;274(8):4561–4569. doi: 10.1074/jbc.274.8.4561. [DOI] [PubMed] [Google Scholar]
  58. Harrison Roger. Structure and function of xanthine oxidoreductase: where are we now? Free Radic Biol Med. 2002 Sep 15;33(6):774–797. doi: 10.1016/s0891-5849(02)00956-5. [DOI] [PubMed] [Google Scholar]
  59. Hassoun P. M., Yu F. S., Cote C. G., Zulueta J. J., Sawhney R., Skinner K. A., Skinner H. B., Parks D. A., Lanzillo J. J. Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury. Am J Respir Crit Care Med. 1998 Jul;158(1):299–305. doi: 10.1164/ajrccm.158.1.9709116. [DOI] [PubMed] [Google Scholar]
  60. Hassoun P. M., Yu F. S., Shedd A. L., Zulueta J. J., Thannickal V. J., Lanzillo J. J., Fanburg B. L. Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression by oxygen tension. Am J Physiol. 1994 Feb;266(2 Pt 1):L163–L171. doi: 10.1152/ajplung.1994.266.2.L163. [DOI] [PubMed] [Google Scholar]
  61. Hellsten-Westing Y. Immunohistochemical localization of xanthine oxidase in human cardiac and skeletal muscle. Histochemistry. 1993 Sep;100(3):215–222. doi: 10.1007/BF00269094. [DOI] [PubMed] [Google Scholar]
  62. Hille R., Nishino T. Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J. 1995 Aug;9(11):995–1003. [PubMed] [Google Scholar]
  63. Hille R. The reaction mechanism of oxomolybdenum enzymes. Biochim Biophys Acta. 1994 Mar 8;1184(2-3):143–169. doi: 10.1016/0005-2728(94)90220-8. [DOI] [PubMed] [Google Scholar]
  64. Hille Russ. Molybdenum and tungsten in biology. Trends Biochem Sci. 2002 Jul;27(7):360–367. doi: 10.1016/s0968-0004(02)02107-2. [DOI] [PubMed] [Google Scholar]
  65. Hoff T., Frandsen G. I., Rocher A., Mundy J. Biochemical and genetic characterization of three molybdenum cofactor hydroxylases in Arabidopsis thaliana. Biochim Biophys Acta. 1998 Jul 9;1398(3):397–402. doi: 10.1016/s0167-4781(98)00085-2. [DOI] [PubMed] [Google Scholar]
  66. Holmes R. S. Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1. Biochem Genet. 1979 Jun;17(5-6):517–527. doi: 10.1007/BF00498887. [DOI] [PubMed] [Google Scholar]
  67. Houde M., Tiveron M. C., Brégégère F. Divergence of the nucleotide sequences encoding xanthine dehydrogenase in Calliphora vicina and Drosophila melanogaster. Gene. 1989 Dec 28;85(2):391–402. doi: 10.1016/0378-1119(89)90432-0. [DOI] [PubMed] [Google Scholar]
  68. Houston M., Chumley P., Radi R., Rubbo H., Freeman B. A. Xanthine oxidase reaction with nitric oxide and peroxynitrite. Arch Biochem Biophys. 1998 Jul 1;355(1):1–8. doi: 10.1006/abbi.1998.0675. [DOI] [PubMed] [Google Scholar]
  69. Huang D. Y., Furukawa A., Ichikawa Y. Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. Arch Biochem Biophys. 1999 Apr 15;364(2):264–272. doi: 10.1006/abbi.1999.1129. [DOI] [PubMed] [Google Scholar]
  70. Huber R., Hof P., Duarte R. O., Moura J. J., Moura I., Liu M. Y., LeGall J., Hille R., Archer M., Romão M. J. A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8846–8851. doi: 10.1073/pnas.93.17.8846. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Hänzelmann Petra, Schwarz Gunter, Mendel Ralf R. Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis. J Biol Chem. 2002 Mar 12;277(21):18303–18312. doi: 10.1074/jbc.M200947200. [DOI] [PubMed] [Google Scholar]
  72. Ichida K., Amaya Y., Noda K., Minoshima S., Hosoya T., Sakai O., Shimizu N., Nishino T. Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene. Gene. 1993 Nov 15;133(2):279–284. doi: 10.1016/0378-1119(93)90652-j. [DOI] [PubMed] [Google Scholar]
  73. Ichida K., Matsumura T., Sakuma R., Hosoya T., Nishino T. Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. Biochem Biophys Res Commun. 2001 Apr 20;282(5):1194–1200. doi: 10.1006/bbrc.2001.4719. [DOI] [PubMed] [Google Scholar]
  74. Ilich Predrag, Hille Russ. Oxo, sulfido, and tellurido Mo-enedithiolate models for xanthine oxidase: understanding the basis of enzyme reactivity. J Am Chem Soc. 2002 Jun 19;124(24):6796–6797. doi: 10.1021/ja011957k. [DOI] [PubMed] [Google Scholar]
  75. Jarasch E. D., Grund C., Bruder G., Heid H. W., Keenan T. W., Franke W. W. Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium. Cell. 1981 Jul;25(1):67–82. doi: 10.1016/0092-8674(81)90232-4. [DOI] [PubMed] [Google Scholar]
  76. Johnson J. L., Rajagopalan K. V., Renier W. O., Van der Burgt I., Ruitenbeek W. Isolated sulfite oxidase deficiency: mutation analysis and DNA-based prenatal diagnosis. Prenat Diagn. 2002 May;22(5):433–436. doi: 10.1002/pd.335. [DOI] [PubMed] [Google Scholar]
  77. Johnson Jean L., Coyne Katharine E., Garrett Robert M., Zabot Marie-Therese, Dorche Claude, Kisker Caroline, Rajagopalan K. V. Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients. Hum Mutat. 2002 Jul;20(1):74–74. doi: 10.1002/humu.9038. [DOI] [PubMed] [Google Scholar]
  78. Johnson Jean L., Coyne Katharine E., Garrett Robert M., Zabot Marie-Therese, Dorche Claude, Kisker Caroline, Rajagopalan K. V. Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients. Hum Mutat. 2002 Jul;20(1):74–74. doi: 10.1002/humu.9038. [DOI] [PubMed] [Google Scholar]
  79. Jordan C. G., Rashidi M. R., Laljee H., Clarke S. E., Brown J. E., Beedham C. Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. J Pharm Pharmacol. 1999 Apr;51(4):411–418. doi: 10.1211/0022357991772619. [DOI] [PubMed] [Google Scholar]
  80. Keith T. P., Riley M. A., Kreitman M., Lewontin R. C., Curtis D., Chambers G. Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster. Genetics. 1987 May;116(1):67–73. doi: 10.1093/genetics/116.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Kim Ha Won, Murakami Akira, Nakamura Yoshimasa, Ohigashi Hajime. Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells. Cancer Lett. 2002 Feb 8;176(1):7–16. doi: 10.1016/s0304-3835(01)00735-2. [DOI] [PubMed] [Google Scholar]
  82. Kirsch J., Betz H. Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature. 1998 Apr 16;392(6677):717–720. doi: 10.1038/33694. [DOI] [PubMed] [Google Scholar]
  83. Kisker C., Schindelin H., Pacheco A., Wehbi W. A., Garrett R. M., Rajagopalan K. V., Enemark J. H., Rees D. C. Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. Cell. 1997 Dec 26;91(7):973–983. doi: 10.1016/s0092-8674(00)80488-2. [DOI] [PubMed] [Google Scholar]
  84. Kisker C., Schindelin H., Rees D. C. Molybdenum-cofactor-containing enzymes: structure and mechanism. Annu Rev Biochem. 1997;66:233–267. doi: 10.1146/annurev.biochem.66.1.233. [DOI] [PubMed] [Google Scholar]
  85. Korthuis R. J., Granger D. N. Reactive oxygen metabolites, neutrophils, and the pathogenesis of ischemic-tissue/reperfusion. Clin Cardiol. 1993 Apr;16(4 Suppl 1):I19–I26. doi: 10.1002/clc.4960161307. [DOI] [PubMed] [Google Scholar]
  86. Krenitsky T. A., Neil S. M., Elion G. B., Hitchings G. H. A comparison of the specificities of xanthine oxidase and aldehyde oxidase. Arch Biochem Biophys. 1972 Jun;150(2):585–599. doi: 10.1016/0003-9861(72)90078-1. [DOI] [PubMed] [Google Scholar]
  87. Kurosaki M., Demontis S., Barzago M. M., Garattini E., Terao M. Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone. Biochem J. 1999 Jul 1;341(Pt 1):71–80. [PMC free article] [PubMed] [Google Scholar]
  88. Kurosaki M., Li Calzi M., Scanziani E., Garattini E., Terao M. Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide. Biochem J. 1995 Feb 15;306(Pt 1):225–234. doi: 10.1042/bj3060225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Kurosaki M., Zanotta S., Li Calzi M., Garattini E., Terao M. Expression of xanthine oxidoreductase in mouse mammary epithelium during pregnancy and lactation: regulation of gene expression by glucocorticoids and prolactin. Biochem J. 1996 Nov 1;319(Pt 3):801–810. doi: 10.1042/bj3190801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Kômoto N., Yukuhiro K., Tamura T. Structure and expression of tandemly duplicated xanthine dehydrogenase genes of the silkworm (Bombyx mori). Insect Mol Biol. 1999 Feb;8(1):73–83. doi: 10.1046/j.1365-2583.1999.810073.x. [DOI] [PubMed] [Google Scholar]
  91. Leimkühler S., Angermüller S., Schwarz G., Mendel R. R., Klipp W. Activity of the molybdopterin-containing xanthine dehydrogenase of Rhodobacter capsulatus can be restored by high molybdenum concentrations in a moeA mutant defective in molybdenum cofactor biosynthesis. J Bacteriol. 1999 Oct;181(19):5930–5939. doi: 10.1128/jb.181.19.5930-5939.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Leimkühler S., Klipp W. Role of XDHC in Molybdenum cofactor insertion into xanthine dehydrogenase of Rhodobacter capsulatus. J Bacteriol. 1999 May;181(9):2745–2751. doi: 10.1128/jb.181.9.2745-2751.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Lin J. K., Shih C. A. Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells. Carcinogenesis. 1994 Aug;15(8):1717–1721. doi: 10.1093/carcin/15.8.1717. [DOI] [PubMed] [Google Scholar]
  94. Linder N., Rapola J., Raivio K. O. Cellular expression of xanthine oxidoreductase protein in normal human tissues. Lab Invest. 1999 Aug;79(8):967–974. [PubMed] [Google Scholar]
  95. Mannering G. J., Deloria L. B., Abbott V. Role of xanthine oxidase in the interferon-mediated depression of the hepatic cytochrome P-450 system in mice. Cancer Res. 1988 Apr 15;48(8):2107–2112. [PubMed] [Google Scholar]
  96. Massey V., Harris C. M. Milk xanthine oxidoreductase: the first one hundred years. Biochem Soc Trans. 1997 Aug;25(3):750–755. doi: 10.1042/bst0250750. [DOI] [PubMed] [Google Scholar]
  97. Massey V., Komai H., Palmer G., Elion G. B. On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines. J Biol Chem. 1970 Jun 10;245(11):2837–2844. [PubMed] [Google Scholar]
  98. McManaman J. L., Hanson L., Neville M. C., Wright R. M. Lactogenic hormones regulate xanthine oxidoreductase and beta-casein levels in mammary epithelial cells by distinct mechanisms. Arch Biochem Biophys. 2000 Jan 15;373(2):318–327. doi: 10.1006/abbi.1999.1573. [DOI] [PubMed] [Google Scholar]
  99. McManaman J. L., Palmer C. A., Wright R. M., Neville M. C. Functional regulation of xanthine oxidoreductase expression and localization in the mouse mammary gland: evidence of a role in lipid secretion. J Physiol. 2002 Dec 1;545(Pt 2):567–579. doi: 10.1113/jphysiol.2002.027185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. McManaman J. L., Shellman V., Wright R. M., Repine J. E. Purification of rat liver xanthine oxidase and xanthine dehydrogenase by affinity chromatography on benzamidine-sepharose. Arch Biochem Biophys. 1996 Aug 1;332(1):135–141. doi: 10.1006/abbi.1996.0325. [DOI] [PubMed] [Google Scholar]
  101. Mendel Ralf R., Schwarz Günter. Biosynthesis and molecular biology of the molybdenum cofactor (Moco). Met Ions Biol Syst. 2002;39:317–368. [PubMed] [Google Scholar]
  102. Mohamedali K. A., Guicherit O. M., Kellems R. E., Rudolph F. B. The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine. J Biol Chem. 1993 Nov 5;268(31):23728–23733. [PubMed] [Google Scholar]
  103. Moriwaki Y., Yamamoto T., Higashino K. Enzymes involved in purine metabolism--a review of histochemical localization and functional implications. Histol Histopathol. 1999 Oct;14(4):1321–1340. doi: 10.14670/HH-14.1321. [DOI] [PubMed] [Google Scholar]
  104. Moriwaki Y., Yamamoto T., Yamakita J., Takahashi S., Higashino K. Comparative localization of aldehyde oxidase and xanthine oxidoreductase activity in rat tissues. Histochem J. 1998 Feb;30(2):69–74. doi: 10.1023/a:1003222831002. [DOI] [PubMed] [Google Scholar]
  105. Nishino T., Nishino T., Noda K., Tsushima K. Structure of xanthine dehydrogenase from chicken and rat liver: chemical modification of NAD binding site with 5'-FSBA. Adv Exp Med Biol. 1989;253B:173–178. doi: 10.1007/978-1-4684-5676-9_26. [DOI] [PubMed] [Google Scholar]
  106. Nishino T., Nishino T. The conversion from the dehydrogenase type to the oxidase type of rat liver xanthine dehydrogenase by modification of cysteine residues with fluorodinitrobenzene. J Biol Chem. 1997 Nov 21;272(47):29859–29864. doi: 10.1074/jbc.272.47.29859. [DOI] [PubMed] [Google Scholar]
  107. Nishino T., Nishino T. The nicotinamide adenine dinucleotide-binding site of chicken liver xanthine dehydrogenase. Evidence for alteration of the redox potential of the flavin by NAD binding or modification of the NAD-binding site and isolation of a modified peptide. J Biol Chem. 1989 Apr 5;264(10):5468–5473. [PubMed] [Google Scholar]
  108. Okamoto Ken, Eger Bryan T., Nishino Tomoko, Kondo Shiro, Pai Emil F., Nishino Takeshi. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J Biol Chem. 2002 Nov 5;278(3):1848–1855. doi: 10.1074/jbc.M208307200. [DOI] [PubMed] [Google Scholar]
  109. Onoue Y. Sulfite oxidase from Merluccius productus. Biochim Biophys Acta. 1980 Sep 9;615(1):48–58. doi: 10.1016/0005-2744(80)90007-8. [DOI] [PubMed] [Google Scholar]
  110. Ori N., Eshed Y., Pinto P., Paran I., Zamir D., Fluhr R. TAO1, a representative of the molybdenum cofactor containing hydroxylases from tomato. J Biol Chem. 1997 Jan 10;272(2):1019–1025. doi: 10.1074/jbc.272.2.1019. [DOI] [PubMed] [Google Scholar]
  111. Page S., Powell D., Benboubetra M., Stevens C. R., Blake D. R., Selase F., Wolstenholme A. J., Harrison R. Xanthine oxidoreductase in human mammary epithelial cells: activation in response to inflammatory cytokines. Biochim Biophys Acta. 1998 Jul 23;1381(2):191–202. doi: 10.1016/s0304-4165(98)00028-2. [DOI] [PubMed] [Google Scholar]
  112. Pence B. C., Reiners J. J., Jr Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters. Cancer Res. 1987 Dec 1;47(23):6388–6392. [PubMed] [Google Scholar]
  113. Pfeffer K. D., Huecksteadt T. P., Hoidal J. R. Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation. J Immunol. 1994 Aug 15;153(4):1789–1797. [PubMed] [Google Scholar]
  114. Poss W. B., Huecksteadt T. P., Panus P. C., Freeman B. A., Hoidal J. R. Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia. Am J Physiol. 1996 Jun;270(6 Pt 1):L941–L946. doi: 10.1152/ajplung.1996.270.6.L941. [DOI] [PubMed] [Google Scholar]
  115. Radi R., Rubbo H., Bush K., Freeman B. A. Xanthine oxidase binding to glycosaminoglycans: kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes. Arch Biochem Biophys. 1997 Mar 1;339(1):125–135. doi: 10.1006/abbi.1996.9844. [DOI] [PubMed] [Google Scholar]
  116. Rashidi M. R., Smith J. A., Clarke S. E., Beedham C. In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab Dispos. 1997 Jul;25(7):805–813. [PubMed] [Google Scholar]
  117. Rebelo J. M., Dias J. M., Huber R., Moura J. J., Romão M. J. Structure refinement of the aldehyde oxidoreductase from Desulfovibrio gigas (MOP) at 1.28 A. J Biol Inorg Chem. 2001 Oct;6(8):791–800. doi: 10.1007/s007750100255. [DOI] [PubMed] [Google Scholar]
  118. Rech S., Deppenmeier U., Gunsalus R. P. Regulation of the molybdate transport operon, modABCD, of Escherichia coli in response to molybdate availability. J Bacteriol. 1995 Feb;177(4):1023–1029. doi: 10.1128/jb.177.4.1023-1029.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  119. Reiners J. J., Jr, Cantu A. R., Rupp T. A. Coordinate modulation of murine hepatic xanthine oxidase activity and the cytochrome P-450 system by interferons. J Interferon Res. 1990 Apr;10(2):109–118. doi: 10.1089/jir.1990.10.109. [DOI] [PubMed] [Google Scholar]
  120. Reiners J. J., Jr, Pence B. C., Barcus M. C., Cantu A. R. 12-O-tetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis. Cancer Res. 1987 Apr 1;47(7):1775–1779. [PubMed] [Google Scholar]
  121. Reiners J. J., Jr, Rupp T. Conversion of xanthine dehydrogenase to xanthine oxidase occurs during keratinocyte differentiation: modulation by 12-O-tetradecanoylphorbol-13-acetate. J Invest Dermatol. 1989 Jul;93(1):132–135. doi: 10.1111/1523-1747.ep12277382. [DOI] [PubMed] [Google Scholar]
  122. Reiners J. J., Jr, Thai G., Rupp T., Cantu A. R. Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part I: Quantitation of superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase. Carcinogenesis. 1991 Dec;12(12):2337–2343. doi: 10.1093/carcin/12.12.2337. [DOI] [PubMed] [Google Scholar]
  123. Reiss J., Cohen N., Dorche C., Mandel H., Mendel R. R., Stallmeyer B., Zabot M. T., Dierks T. Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency. Nat Genet. 1998 Sep;20(1):51–53. doi: 10.1038/1706. [DOI] [PubMed] [Google Scholar]
  124. Reiss J., Dorche C., Stallmeyer B., Mendel R. R., Cohen N., Zabot M. T. Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. Am J Hum Genet. 1999 Mar;64(3):706–711. doi: 10.1086/302296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  125. Reiss J. Genetics of molybdenum cofactor deficiency. Hum Genet. 2000 Feb;106(2):157–163. doi: 10.1007/s004390051023. [DOI] [PubMed] [Google Scholar]
  126. Reiss J., Gross-Hardt S., Christensen E., Schmidt P., Mendel R. R., Schwarz G. A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency. Am J Hum Genet. 2000 Nov 28;68(1):208–213. doi: 10.1086/316941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  127. Robertson I. G., Gamage R. S. Methadone: a potent inhibitor of rat liver aldehyde oxidase. Biochem Pharmacol. 1994 Feb 9;47(3):584–587. doi: 10.1016/0006-2952(94)90192-9. [DOI] [PubMed] [Google Scholar]
  128. Romão M. J., Archer M., Moura I., Moura J. J., LeGall J., Engh R., Schneider M., Hof P., Huber R. Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas. Science. 1995 Nov 17;270(5239):1170–1176. doi: 10.1126/science.270.5239.1170. [DOI] [PubMed] [Google Scholar]
  129. Romão M. J., Huber R. Crystal structure and mechanism of action of the xanthine oxidase-related aldehyde oxidoreductase from Desulfovibrio gigas. Biochem Soc Trans. 1997 Aug;25(3):755–757. doi: 10.1042/bst0250755. [DOI] [PubMed] [Google Scholar]
  130. Rouquette M., Page S., Bryant R., Benboubetra M., Stevens C. R., Blake D. R., Whish W. D., Harrison R., Tosh D. Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture. FEBS Lett. 1998 Apr 24;426(3):397–401. doi: 10.1016/s0014-5793(98)00385-8. [DOI] [PubMed] [Google Scholar]
  131. Saksela M., Lapatto R., Raivio K. O. Xanthine oxidoreductase gene expression and enzyme activity in developing human tissues. Biol Neonate. 1998 Oct;74(4):274–280. doi: 10.1159/000014034. [DOI] [PubMed] [Google Scholar]
  132. Saksela M., Raivio K. O. Cloning and expression in vitro of human xanthine dehydrogenase/oxidase. Biochem J. 1996 Apr 1;315(Pt 1):235–239. doi: 10.1042/bj3150235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Sato A., Nishino T., Noda K., Amaya Y., Nishino T. The structure of chicken liver xanthine dehydrogenase. cDNA cloning and the domain structure. J Biol Chem. 1995 Feb 10;270(6):2818–2826. doi: 10.1074/jbc.270.6.2818. [DOI] [PubMed] [Google Scholar]
  134. Sekimoto H., Seo M., Dohmae N., Takio K., Kamiya Y., Koshiba T. Cloning and molecular characterization of plant aldehyde oxidase. J Biol Chem. 1997 Jun 13;272(24):15280–15285. doi: 10.1074/jbc.272.24.15280. [DOI] [PubMed] [Google Scholar]
  135. Sekimoto H., Seo M., Kawakami N., Komano T., Desloire S., Liotenberg S., Marion-Poll A., Caboche M., Kamiya Y., Koshiba T. Molecular cloning and characterization of aldehyde oxidases in Arabidopsis thaliana. Plant Cell Physiol. 1998 Apr;39(4):433–442. doi: 10.1093/oxfordjournals.pcp.a029387. [DOI] [PubMed] [Google Scholar]
  136. Shaw S., Jayatilleke E. The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat. Biochem J. 1990 Jun 15;268(3):579–583. doi: 10.1042/bj2680579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. Smith J. K., Carden D. L., Korthuis R. J. Activated neutrophils increase microvascular permeability in skeletal muscle: role of xanthine oxidase. J Appl Physiol (1985) 1991 May;70(5):2003–2009. doi: 10.1152/jappl.1991.70.5.2003. [DOI] [PubMed] [Google Scholar]
  138. Sofia H. J., Chen G., Hetzler B. G., Reyes-Spindola J. F., Miller N. E. Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. Nucleic Acids Res. 2001 Mar 1;29(5):1097–1106. doi: 10.1093/nar/29.5.1097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Stallmeyer B., Drugeon G., Reiss J., Haenni A. L., Mendel R. R. Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames. Am J Hum Genet. 1999 Mar;64(3):698–705. doi: 10.1086/302295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Stallmeyer B., Schwarz G., Schulze J., Nerlich A., Reiss J., Kirsch J., Mendel R. R. The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1333–1338. doi: 10.1073/pnas.96.4.1333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  141. Stirpe F., Della Corte E. The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O). J Biol Chem. 1969 Jul 25;244(14):3855–3863. [PubMed] [Google Scholar]
  142. Sugihara K., Kitamura S., Yamada T., Ohta S., Yamashita K., Yasuda M., Fujii-Kuriyama Y. Aryl hydrocarbon receptor (AhR)-mediated induction of xanthine oxidase/xanthine dehydrogenase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Biophys Res Commun. 2001 Mar;281(5):1093–1099. doi: 10.1006/bbrc.2001.4464. [DOI] [PubMed] [Google Scholar]
  143. Terada L. S., Arnold P. D. Xanthine oxidase does not mediate the antiproliferative effects of interferon-gamma in human umbilical vein endothelial cells. J Interferon Res. 1993 Dec;13(6):419–422. doi: 10.1089/jir.1993.13.419. [DOI] [PubMed] [Google Scholar]
  144. Terao M., Cazzaniga G., Ghezzi P., Bianchi M., Falciani F., Perani P., Garattini E. Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo. Biochem J. 1992 May 1;283(Pt 3):863–870. doi: 10.1042/bj2830863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. Terao M., Kurosaki M., Demontis S., Zanotta S., Garattini E. Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin. Biochem J. 1998 Jun 1;332(Pt 2):383–393. doi: 10.1042/bj3320383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  146. Terao M., Kurosaki M., Marini M., Vanoni M. A., Saltini G., Bonetto V., Bastone A., Federico C., Saccone S., Fanelli R. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. J Biol Chem. 2001 Sep 18;276(49):46347–46363. doi: 10.1074/jbc.M105744200. [DOI] [PubMed] [Google Scholar]
  147. Terao M., Kurosaki M., Saltini G., Demontis S., Marini M., Salmona M., Garattini E. Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. J Biol Chem. 2000 Sep 29;275(39):30690–30700. doi: 10.1074/jbc.M005355200. [DOI] [PubMed] [Google Scholar]
  148. Terao M., Kurosaki M., Zanotta S., Garattini E. The xanthine oxidoreductase gene: structure and regulation. Biochem Soc Trans. 1997 Aug;25(3):791–796. doi: 10.1042/bst0250791. [DOI] [PubMed] [Google Scholar]
  149. Truglio James J., Theis Karsten, Leimkühler Silke, Rappa Roberto, Rajagopalan K. V., Kisker Caroline. Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. Structure. 2002 Jan;10(1):115–125. doi: 10.1016/s0969-2126(01)00697-9. [DOI] [PubMed] [Google Scholar]
  150. Tsuchida S., Yamada R., Ikemoto S., Tagawa M. Molecular cloning of a cDNA coding for feline liver xanthine dehydrogenase. J Vet Med Sci. 2001 Mar;63(3):353–355. doi: 10.1292/jvms.63.353. [DOI] [PubMed] [Google Scholar]
  151. Turner N. A., Doyle W. A., Ventom A. M., Bray R. C. Properties of rabbit liver aldehyde oxidase and the relationship of the enzyme to xanthine oxidase and dehydrogenase. Eur J Biochem. 1995 Sep 1;232(2):646–657. [PubMed] [Google Scholar]
  152. Umezawa K., Akaike T., Fujii S., Suga M., Setoguchi K., Ozawa A., Maeda H. Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice. Infect Immun. 1997 Jul;65(7):2932–2940. doi: 10.1128/iai.65.7.2932-2940.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  153. Vorbach Claudia, Scriven Alistair, Capecchi Mario R. The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes Dev. 2002 Dec 15;16(24):3223–3235. doi: 10.1101/gad.1032702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  154. Wajner M., Harkness R. A. Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues. Biochim Biophys Acta. 1989 Apr 25;991(1):79–84. doi: 10.1016/0304-4165(89)90031-7. [DOI] [PubMed] [Google Scholar]
  155. Warner C. K., Finnerty V. Molybdenum hydroxylases in Drosophila. II. Molybdenum cofactor in xanthine dehydrogenase, aldehyde oxidase and pyridoxal oxidase. Mol Gen Genet. 1981;184(1):92–96. doi: 10.1007/BF00271201. [DOI] [PubMed] [Google Scholar]
  156. Witte C. P., Igeño M. I., Mendel R., Schwarz G., Fernández E. The Chlamydomonas reinhardtii MoCo carrier protein is multimeric and stabilizes molybdopterin cofactor in a molybdate charged form. FEBS Lett. 1998 Jul 17;431(2):205–209. doi: 10.1016/s0014-5793(98)00756-x. [DOI] [PubMed] [Google Scholar]
  157. Wright R. M., Clayton D. A., Riley M. G., McManaman J. L., Repine J. E. cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1). Differences in redox status may distinguish male and female forms of hepatic APX. J Biol Chem. 1999 Feb 5;274(6):3878–3886. doi: 10.1074/jbc.274.6.3878. [DOI] [PubMed] [Google Scholar]
  158. Wright R. M., McManaman J. L., Repine J. E. Alcohol-induced breast cancer: a proposed mechanism. Free Radic Biol Med. 1999 Feb;26(3-4):348–354. doi: 10.1016/s0891-5849(98)00204-4. [DOI] [PubMed] [Google Scholar]
  159. Wright R. M., Vaitaitis G. M., Wilson C. M., Repine T. B., Terada L. S., Repine J. E. cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10690–10694. doi: 10.1073/pnas.90.22.10690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  160. Wuebbens M. M., Rajagopalan K. V. Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies. J Biol Chem. 1995 Jan 20;270(3):1082–1087. doi: 10.1074/jbc.270.3.1082. [DOI] [PubMed] [Google Scholar]
  161. Wuebbens M. M., Rajagopalan K. V. Structural characterization of a molybdopterin precursor. J Biol Chem. 1993 Jun 25;268(18):13493–13498. [PubMed] [Google Scholar]
  162. Xu P., Huecksteadt T. P., Harrison R., Hoidal J. R. Molecular cloning, tissue expression of human xanthine dehydrogenase. Biochem Biophys Res Commun. 1995 Oct 4;215(1):429–429. doi: 10.1006/bbrc.1995.2482. [DOI] [PubMed] [Google Scholar]
  163. Xu P., Huecksteadt T. P., Hoidal J. R. Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics. 1996 Jun 1;34(2):173–180. doi: 10.1006/geno.1996.0262. [DOI] [PubMed] [Google Scholar]
  164. Xu P., Zhu X. L., Huecksteadt T. P., Brothman A. R., Hoidal J. R. Assignment of human xanthine dehydrogenase gene to chromosome 2p22. Genomics. 1994 Sep 1;23(1):289–291. doi: 10.1006/geno.1994.1498. [DOI] [PubMed] [Google Scholar]
  165. Yang Y., Hentati A., Deng H. X., Dabbagh O., Sasaki T., Hirano M., Hung W. Y., Ouahchi K., Yan J., Azim A. C. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet. 2001 Oct;29(2):160–165. doi: 10.1038/ng1001-160. [DOI] [PubMed] [Google Scholar]
  166. Yoshihara S., Tatsumi K. Involvement of growth hormone as a regulating factor in sex differences of mouse hepatic aldehyde oxidase. Biochem Pharmacol. 1997 Apr 25;53(8):1099–1105. doi: 10.1016/s0006-2952(97)00088-9. [DOI] [PubMed] [Google Scholar]
  167. de Jong J. W., van der Meer P., Nieukoop A. S., Huizer T., Stroeve R. J., Bos E. Xanthine oxidoreductase activity in perfused hearts of various species, including humans. Circ Res. 1990 Sep;67(3):770–773. doi: 10.1161/01.res.67.3.770. [DOI] [PubMed] [Google Scholar]

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