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. 2004 Apr 15;379(Pt 2):229–233. doi: 10.1042/BJ20040134

Intracerebroventricular leptin regulates hepatic cholesterol metabolism.

Sonya Vanpatten 1, George B Karkanias 1, Luciano Rossetti 1, David E Cohen 1
PMCID: PMC1224095  PMID: 14984364

Abstract

To elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV leptin was as effective as a continuous IV infusion of high-dose leptin at decreasing the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase. These results indicate that the hepatic response to leptin is transduced via the central nervous system.

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Selected References

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