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. 1984 Dec;108(4):1013–1020. doi: 10.1093/genetics/108.4.1013

Characterization of a Recombinant Mouse t Haplotype That Expresses a Dominant Lethal Maternal Effect

Heinz Winking 1,2, Lee M Silver 1,2
PMCID: PMC1224259  PMID: 6510705

Abstract

The twLub2 chromosome was generated by rare recombination between a complete t haplotype and a wild-type form of mouse chromosome 17. This recombinant chromosome expresses a dominant lethal effect in all embryos that inherit the mutant chromosome from their mothers. The phenotype of this maternal effect is indistinguishable from that expressed by the previously described Thp deletion chromosome. It appears likely that the crossing over event that gave rise to twLub2 was unequal and resulted in the alteration or deletion of a gene (which is named the T-associated maternal effect locus, Tme) that must be inherited from the mother in order for normal development to proceed through late stages of gestation. The results presented here allow a mapping of the Tme locus between the quaking and tufted loci which are 3 cM apart within the proximal region of chromosome 17.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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