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. 1988 Aug 1;114(4):347–358. doi: 10.1007/BF02128177

Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes

Margaretha Jennerwein 1, Beate Wappes 1, Ronald Gust 1, Helmut Schönenberge 1,✉, Jürgen Engel 2, Siegfried Seeber 3, Reinhardt Osieka 4
PMCID: PMC12243756  PMID: 3410875

Abstract

Diastereomeric para-substituted dichloro-(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.

Key words: Ring substituents; Antitumor effect; Dichloro (1,2-diphenylethylenediamine)platinum(II) complexes

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