Abstract
The regenerative potential of completely transected tendon has been assessed in rat extensor tendon. Collagen fibril diameter distributions were calculated within the gap region of the healing tissue at 10, 30, 60, 120 and 240 days postoperatively. At each age the distribution was found to be unimodal with no indication of any return of bimodality. These results suggest that mechanical stimuli may be a controlling factor in determining fibril diameters and that mature tendon may be unable to reproduce a bimodal collagen fibril diameter distribution subsequent to trauma.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gelberman R. H., Manske P. R. Factors influencing flexor tendon adhesions. Hand Clin. 1985 Feb;1(1):35–42. [PubMed] [Google Scholar]
- Gelberman R. H., Vande Berg J. S., Lundborg G. N., Akeson W. H. Flexor tendon healing and restoration of the gliding surface. An ultrastructural study in dogs. J Bone Joint Surg Am. 1983 Jan;65(1):70–80. [PubMed] [Google Scholar]
- Gelberman R. H., Woo S. L., Lothringer K., Akeson W. H., Amiel D. Effects of early intermittent passive mobilization on healing canine flexor tendons. J Hand Surg Am. 1982 Mar;7(2):170–175. doi: 10.1016/s0363-5023(82)80083-x. [DOI] [PubMed] [Google Scholar]
- Matthew C., Moore M. J., Campbell L. A quantitative ultrastructural study of collagen fibril formation in the healing extensor digitorum longus tendon of the rat. J Hand Surg Br. 1987 Oct;12(3):313–320. doi: 10.1016/0266-7681_87_90180-x. [DOI] [PubMed] [Google Scholar]
- Michna H. Morphometric analysis of loading-induced changes in collagen-fibril populations in young tendons. Cell Tissue Res. 1984;236(2):465–470. doi: 10.1007/BF00214251. [DOI] [PubMed] [Google Scholar]
- Parry D. A., Barnes G. R., Craig A. S. A comparison of the size distribution of collagen fibrils in connective tissues as a function of age and a possible relation between fibril size distribution and mechanical properties. Proc R Soc Lond B Biol Sci. 1978 Dec 18;203(1152):305–321. doi: 10.1098/rspb.1978.0107. [DOI] [PubMed] [Google Scholar]
- Postacchini F., Accinni L., Natali P. G., Ippolito E., DeMartino C. Regeneration of rabbit calcaneal tendon: a morphological and immunochemical study. Cell Tissue Res. 1978 Dec 14;195(1):81–97. doi: 10.1007/BF00233678. [DOI] [PubMed] [Google Scholar]
- Postacchini F., De Martino C. Regeneration of rabbit calcaneal tendon maturation of collagen and elastic fibers following partial tenotomy. Connect Tissue Res. 1980;8(1):41–47. doi: 10.3109/03008208009152120. [DOI] [PubMed] [Google Scholar]