Abstract
A translocation in which a segment of chromosome 3 is inserted into the Y chromosome was found to contain the acid phosphatase-1 gene (Acph-1). In flies hyperploid for that gene, acid phosphatase-1 levels are proportional to the dose of the gene. The locus is placed within the salivary chromosome subdivisions 99D and 99E on the basis of its inclusion in the translocated segment and on the previous placement of the claret locus. Several chromosomal rearrangements involving heterochromatic breakpoints and euchromatic breakpoints adjacent to 99D-99E were tested for possible position-effect variegation of acid phosphatase-1. No decrease in the synthesis of the electrophoretic subunit encoded by the relocated gene was observed within any of the rearrangements.
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Selected References
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- Baker W. K. Position-effect variegation. Adv Genet. 1968;14:133–169. [PubMed] [Google Scholar]
- Gowen J. W., Gay E. H. EFFECT OF TEMPERATURE ON EVERSPORTING EYE COLOR IN DROSOPHILA MELANOGASTER. Science. 1933 Mar 24;77(1995):312–312. doi: 10.1126/science.77.1995.312. [DOI] [PubMed] [Google Scholar]
- Hessler A Y. V-Type Position Effects at the Light Locus in Drosophila Melanogaster. Genetics. 1958 May;43(3):395–403. doi: 10.1093/genetics/43.3.395. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kankel D. R., Hall J. C. Fate mapping of nervous system and other internal tissues in genetic mosaics of Drosophila melanogaster. Dev Biol. 1976 Jan;48(1):1–24. doi: 10.1016/0012-1606(76)90041-5. [DOI] [PubMed] [Google Scholar]
- Lindsley D. L., Sandler L., Baker B. S., Carpenter A. T., Denell R. E., Hall J. C., Jacobs P. A., Miklos G. L., Davis B. K., Gethmann R. C. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972 May;71(1):157–184. doi: 10.1093/genetics/71.1.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MacIntyre R. The genetics of an acid phosphatase in Drosophila melanogaster and Drosophila simulans. Genetics. 1966 Mar;53(3):461–474. doi: 10.1093/genetics/53.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tobler J., Bowman J. T., Simmons J. R. Gene modulation in Drosophila: dosage compensation and relocated v + genes. Biochem Genet. 1971 Apr;5(2):111–117. doi: 10.1007/BF00485639. [DOI] [PubMed] [Google Scholar]