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. 1996 Apr;70(4):1618–1627. doi: 10.1016/S0006-3495(96)79725-4

Monte Carlo modeling of small-angle scattering data from non-interacting homogeneous and heterogeneous particles in solution.

S J Henderson
PMCID: PMC1225131  PMID: 8785321

Abstract

A Monte Carlo algorithm that rapidly generates the scattered intensity function for complex heterogeneous particles is described. The heterogeneous particles are built from any number and orientation of simple building blocks, which include ellipsoidal shells, hollow ellipsoidal cylinders, ellipsoidal helices, triangular prisms, rectangular prisms, and semi-ellipsoidal shells. Applications are discussed such as real proteins and their complexes, polysaccharides, void effects on I(q), Guinier range estimation, and calculation of Stuhrmann plots.

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Selected References

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  1. Graziano V., Gerchman S. E., Schneider D. K., Ramakrishnan V. Histone H1 is located in the interior of the chromatin 30-nm filament. Nature. 1994 Mar 24;368(6469):351–354. doi: 10.1038/368351a0. [DOI] [PubMed] [Google Scholar]
  2. Henderson S. J., Newsholme P., Heidorn D. B., Mitchell R., Seeger P. A., Walsh D. A., Trewhella J. Solution structure of phosphorylase kinase studied using small-angle X-ray and neutron scattering. Biochemistry. 1992 Jan 21;31(2):437–442. doi: 10.1021/bi00117a019. [DOI] [PubMed] [Google Scholar]
  3. Henderson S. J., Serpersu E. H., Gerhardt B. S., Bunick G. J. Conformational changes in yeast phosphoglycerate kinase upon substrate binding. Biophys Chem. 1994 Dec;53(1-2):95–104. doi: 10.1016/0301-4622(94)00080-8. [DOI] [PubMed] [Google Scholar]
  4. Ibel K. Comparison of neutron and X-ray scattering of dilute myoglobin solutions. J Mol Biol. 1975 Apr 5;93(2):255–265. doi: 10.1016/0022-2836(75)90131-x. [DOI] [PubMed] [Google Scholar]
  5. Ibel K., May R. P., Sandberg M., Mascher E., Greijer E., Lundahl P. Structure of dodecyl sulfate-protein complexes at subsaturating concentrations of free detergent. Biophys Chem. 1994 Dec;53(1-2):77–83. doi: 10.1016/0301-4622(94)00078-6. [DOI] [PubMed] [Google Scholar]
  6. Jacobsen E. A., Pedersen H. K., Klow N. E., Refsum H. Cardiac electrophysiology, arrhythmogenic mechanisms and roentgen contrast media. Acta Radiol Suppl. 1995;399:105–114. doi: 10.1177/0284185195036s39913. [DOI] [PubMed] [Google Scholar]
  7. Kratky O., Pilz I. Recent advances and applications of diffuse X-ray small-angle scattering on biopolymers in dilute solutions. Q Rev Biophys. 1972 Nov;5(4):481–537. doi: 10.1017/s0033583500001049. [DOI] [PubMed] [Google Scholar]
  8. Ninio J., Luzzati V., Yaniv M. Comparative small-angle x-ray scattering studies on unacylated, acylated and cross-linked Escherichia coli transfer RNA I Val . J Mol Biol. 1972 Nov 14;71(2):217–229. doi: 10.1016/0022-2836(72)90347-6. [DOI] [PubMed] [Google Scholar]
  9. Saitô H., Yoshioka Y., Uehara N., Aketagawa J., Tanaka S., Shibata Y. Relationship between conformation and biological response for (1----3)-beta-D-glucans in the activation of coagulation factor G from limulus amebocyte lysate and host-mediated antitumor activity. Demonstration of single-helix conformation as a stimulant. Carbohydr Res. 1991 Sep 18;217:181–190. doi: 10.1016/0008-6215(91)84128-2. [DOI] [PubMed] [Google Scholar]
  10. Thiyagarajan P., Henderson S. J., Joachimiak A. Solution structures of GroEL and its complex with rhodanese from small-angle neutron scattering. Structure. 1996 Jan 15;4(1):79–88. doi: 10.1016/s0969-2126(96)00011-1. [DOI] [PubMed] [Google Scholar]
  11. Wu C. F., Chen S. H. Small angle neutron and x-ray scattering studies of concentrated protein solutions. II. Cytochrome C. Biopolymers. 1988 Jul;27(7):1065–1083. doi: 10.1002/bip.360270703. [DOI] [PubMed] [Google Scholar]

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