Abstract
The anti-neoplastic activity of N-[N′-(2-chloroethyl)-N-nitrosocarbamoyl(CNC)]-alanine, CNC-alanyl-alanine, CNC-alanine-methylamide and CNC-glycine-methylamide was examined in murine transplantable colon tumours (MAC). The methylamide derivatives were highly active against a solid adenocarcinoma (MAC 13) and an ascitic adenocarcinoma (MAC 15A). CNC-alanyl-alanine was also highly active against MAC 15A. Responses of the three latter agents against the ascitic tumour were better than for any previously tested drugs including the nitrosoureas but their eventual usefulness cannot be determined without further toxicological studies.
Key words: 2-chloroethylnitrosocarbamoyl, Amino acids, Derivatives, Nitrosoureas, Experimental chemotherapy
Footnotes
This work was supported by the Turner/Whyte Watson Cancer Research Trust (Bradford) and was undertaken within the Screening and Pharmacology Group of the EORTC
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