Abstract
Superoxide dismutase and catalase were demonstrated to favour the multiplication of ascites tumour cells in vitro. It is proposed that these enzymes neutralize the O.2 − and H2O2 that may accumulate in the neoplastic cell and that cell damage occurs because the cellular levels of both enzymes are low.
Key words: Superoxide dismutase, Catalase, Ascites tumour, Cell proliferation
References
- Apffel CA (1972) Deactivation of tumor cells by blocking of sulfydryls. Proc. Am Assoc Cancer Res 13:1 [Google Scholar]
- Apffel CA, Walker JE (1973) Tumor growth and disulfide reduction. J Natl Cancer Inst 51:575–583 [PubMed] [Google Scholar]
- Asada K, Kanamatsu S (1976) Reactivity of thiols with superoxide radicals. Agric Biol Chem 40:1891–1897 [Google Scholar]
- Bartkowiak A, Bartkowiak J (1981) Superoxide dismutase and catalase activities in normal and cancerous tissues. Comp Biochem Physiol 70-B:819–820 [Google Scholar]
- Biancifiori C, Caschera F (1960) The gradual conversion of a spontaneous mouse mammary carcinoma to an ascites tumour. Br J Cancer 14:668–671 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doroshow J, Hochstein P (1982) Redox cycling and the mechanism of action of antibiotics in neoplastic diseases. In Autor AP (ed): Pathology of oxygen. Academic Press, New York, pp 245–259 [Google Scholar]
- Fridovich I (1982) Superoxide dismutase in biology and medicine. In Autor AP (ed): Pathology of oxygen. Academic Press, New York, pp 1–19 [Google Scholar]
- Greenstein JP (1954) Biochemistry of Cancer (2nd, ed). Academic Press, New York p 402 [Google Scholar]
- Giles KW, Mayers S (1965) An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature 206:9314334364 [Google Scholar]
- Kellog EW, Fridovich I (1975) Superoxide, hydrogen peroxide and singlet oxygen in lipid peroxidation by a xanthine oxidase system. J Biol Chem 250:8812–8817 [PubMed] [Google Scholar]
- Kellog EW, Fridovich I (1977) Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide. J Biol Chem 252:6721–6728 [PubMed] [Google Scholar]
- Kelly K, Barefoot C, Sehon A, Petkau A (1978) Bovine superoxide dismutase: a radioimmunoassay. Arch Biochem Biophys 190:531–533 [DOI] [PubMed] [Google Scholar]
- Liotti FS, Menghini AR, Guerrieri P, Talesa V, Bodo M (1984) Effects of ascorbic and dehydroascorbic acid on the multiplication of tumor ascites cells in vitro. J Cancer Res Clin Oncol 108:230–232 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nishikimi M (1975) Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system. Biochem Biophys Res Commun 63:463–468 [DOI] [PubMed] [Google Scholar]
- Oberley LW (1984) The role of superoxide dismutase and gene amplification in carcinogenesis. J Theor Biol 106:403–422 [DOI] [PubMed] [Google Scholar]
- Oberley LW, Buettner GR (1979) Role of superoxide dismutase in cancer: a review. Cancer Res 39:1141–1149 [PubMed] [Google Scholar]
- Oberley LW, Oberley TD, Buettner GR (1981) Cell division in normal and transformed cells: the possible role of superoxide and hydrogen peroxide. Med Hypotheses 7:21–42 [DOI] [PubMed] [Google Scholar]
- Peskin AV, Koen YM, Zbarsky IB (1977) Superoxide dismutase and glutathione peroxidase acitivities in tumors. FEBS Lett 78:41–45 [DOI] [PubMed] [Google Scholar]
- Peters JW, Foote CS (1976) Chemistry of superoxide anion. II —Reaction with hydroperoxides. J Am Chem Soc 98:873–875 [Google Scholar]
- Petkau A (1978) Radiation protection by superoxide dismutase. Photochem Photobiol 28:765–768 [DOI] [PubMed] [Google Scholar]
- Petkau A, Kelly K, Chelack WS, Pleskach SD, Barefoot C, Mecker BE (1975) Radioprotection of bone marrow stem cells by superoxide dismutase. Biochem Biophys Res Commun 67:1167–1174 [DOI] [PubMed] [Google Scholar]
- Rosin MP, San RHG, Stich HF (1980) Mutagenic acitivity of ascorbate in mammalian cell cultures. Cancer Lett 8:299–305 [DOI] [PubMed] [Google Scholar]
- Sahu SK, Oberley LW, Stevens RH, Riley EF (1977) Superoxide dismutase activity of Ehrlich ascites tumor cells. J Natl Cancer Inst 58:1125–1127 [DOI] [PubMed] [Google Scholar]
- Solanki V, Rana RS, Slaga TJ (1981) Diminution of mouse epidermal superoxide dismutase and catalase activities by tumor promoters. Carcinogenesis 2:1141–1146 [DOI] [PubMed] [Google Scholar]
- Som S, Raha C, Chatterjee JB (1983) Ascorbic acid: a scavenger of superoxide radical. Acta Vitaminol Enzymol 5:243–250 [PubMed] [Google Scholar]
