Skip to main content
NCBI home page
Biophysical Journal logoLink to Biophysical Journal
. 1993 Oct;65(4):1429–1432. doi: 10.1016/S0006-3495(93)81206-2

Support for the shape concept of lipid structure based on a headgroup volume approach.

Y C Lee 1, T F Taraschi 1, N Janes 1
PMCID: PMC1225869  PMID: 8274636

Abstract

Headgroup volumes of seven dioleoyl lipid species, calculated from covalent radii, are shown to correlate linearly (r = 0.95) with the ability of those lipids to alter the midpoint temperature of the lamellar to inverted hexagonal phase transition (L alpha-->HII) of a 95 mole fraction percent phosphatidylethanolamine matrix. The results illustrate the utility of the shape concept and basic considerations of headgroup volume as a predictive tool for the determination of lipid structure.

Full text

PDF
1429

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTLETT G. R. Phosphorus assay in column chromatography. J Biol Chem. 1959 Mar;234(3):466–468. [PubMed] [Google Scholar]
  2. Boggs J. M. Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function. Biochim Biophys Acta. 1987 Oct 5;906(3):353–404. doi: 10.1016/0304-4157(87)90017-7. [DOI] [PubMed] [Google Scholar]
  3. Browning J. L. Motions and interactions of phospholipid head groups at the membrane surface. 2. Simple alkyl head groups. Biochemistry. 1981 Dec 8;20(25):7123–7133. doi: 10.1021/bi00528a012. [DOI] [PubMed] [Google Scholar]
  4. Epand R. M. Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines. Biochemistry. 1985 Dec 3;24(25):7092–7095. doi: 10.1021/bi00346a011. [DOI] [PubMed] [Google Scholar]
  5. Gruner S. M., Shyamsunder E. Is the mechanism of general anesthesia related to lipid membrane spontaneous curvature? Ann N Y Acad Sci. 1991;625:685–697. doi: 10.1111/j.1749-6632.1991.tb33902.x. [DOI] [PubMed] [Google Scholar]
  6. Israelachvili J. N., Marcelja S., Horn R. G. Physical principles of membrane organization. Q Rev Biophys. 1980 May;13(2):121–200. doi: 10.1017/s0033583500001645. [DOI] [PubMed] [Google Scholar]
  7. Lafleur M., Bloom M., Cullis P. R. Lipid polymorphism and hydrocarbon order. Biochem Cell Biol. 1990 Jan;68(1):1–8. doi: 10.1139/o90-001. [DOI] [PubMed] [Google Scholar]
  8. Lewis R. N., Mannock D. A., McElhaney R. N., Turner D. C., Gruner S. M. Effect of fatty acyl chain length and structure on the lamellar gel to liquid-crystalline and lamellar to reversed hexagonal phase transitions of aqueous phosphatidylethanolamine dispersions. Biochemistry. 1989 Jan 24;28(2):541–548. doi: 10.1021/bi00428a020. [DOI] [PubMed] [Google Scholar]
  9. Seddon J. M., Cevc G., Marsh D. Calorimetric studies of the gel-fluid (L beta-L alpha) and lamellar-inverted hexagonal (L alpha-HII) phase transitions in dialkyl- and diacylphosphatidylethanolamines. Biochemistry. 1983 Mar 1;22(5):1280–1289. doi: 10.1021/bi00274a045. [DOI] [PubMed] [Google Scholar]
  10. Shyamsunder E., Gruner S. M., Tate M. W., Turner D. C., So P. T., Tilcock C. P. Observation of inverted cubic phase in hydrated dioleoylphosphatidylethanolamine membranes. Biochemistry. 1988 Apr 5;27(7):2332–2336. doi: 10.1021/bi00407a014. [DOI] [PubMed] [Google Scholar]

Articles from Biophysical Journal are provided here courtesy of The Biophysical Society

RESOURCES