Author Correction: The novel sophoridine derivate IMB-HDC induced lessened phosphorylation of STAT5a at 694 and 780 and promoted DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation

Correction to: Acta Pharmacologica Sinica 10.1038/s41401-019-0333-6, published online 13 January 2020

The authors would like to apologize for the errors in the previously published images of Fig. 1e and Fig. 7d due to an oversight during the preparation of the figures. The authors have carefully checked the raw data and corrected these accidentally confused figures. The wrong data are replaced by right ones of the same batch as follows. The updated data does not impact the statistical results and the conclusion.

It is important to note that these corrections do not alter the findings or conclusions of the paper. The overall interpretation and impact of the study remain unchanged. The authors sincerely apologize for any inconvenience caused to the journal and its readers. The authors are grateful for the understanding and support of the editorial team and the readers in rectifying these errors.

Correct figures 1e is:

Fig. 1. IMB-HDC suppresses cancer cells proliferation in time- and dose-dependent manner.

e HCT-8 cells and MIA-PaCa-2 cells were seeded in a six-well plate, after 24 h, various concentrations of IMB-HDC were added and continued to be incubated with cancer cells for 7 days, and then visible colonies were counted as described in the “Materials and methods” section. Colony-formation rate = (number of colonies/number of seeded cells) × 100%. *P < 0.05; **P < 0.01.

Correct figures 7d is:

Fig. 7. IMB-HDC suppresses tumor cells proliferation in vivo.

Nude mice (n = 5) bearing HepG2 xenografts were administered IMB-HDC i.p. ×1 every second day after tumor implantation. The results were recorded every 3 days after tumor implantation with all mice alive. Mice were killed when the tumor volume of the control group reached 1000 mm³; the tumor loads and other tissues were isolated and prepared sections. d H&E staining of tissue sections from various treatment groups.