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. 1997 Sep 15;157(6):715–725.

Report of the Canadian Hypertension Society Consensus Conference: 1. Definitions, evaluation and classification of hypertensive disorders in pregnancy

M E Helewa 1, R F Burrows 1, J Smith 1, K Williams 1, P Brain 1, S W Rabkin 1
PMCID: PMC1228113  PMID: 9307560

Abstract

OBJECTIVES: To provide Canadian physicians with a standard definition of hypertension in pregnancy, recommendations for laboratory investigations and tests for the assessment and management of hypertensive disorders in pregnancy, and a classification of such disorders. OPTIONS: To improve or not improve Canadian uniformity and standardization in the investigation and classification of hypertensive disorders in pregnancy. OUTCOMES: 1) Accuracy, reliability and practicality of diagnostic clinical criteria for hypertensive disorders in pregnancy. 2) Laboratory tests useful to determine severity and prognosis of disorders as measured by maternal and neonatal adverse outcomes. 3) A classification of disorders for use by Canadian physicians to facilitate uniformity and diffusion of research through a common language. EVIDENCE: Articles on hypertensive disorders in pregnancy published from 1966 to 1996, retrieved through MEDLINE search, related to definitions, tests, diagnostic criteria and classification, as well as documents on diagnosis and classification from authorities in the United States, Europe and Australia and from special interest groups. VALUES: High priority was given to the principle of preventing adverse maternal and neonatal outcomes through the provision of diagnostic criteria for severity and prognosis and through dissemination of reliable and pertinent information and research results using a common language. BENEFITS, HARMS AND COST: Higher degree of vigilance in diagnosing hypertensive disorders in pregnancy, allowing for earlier assessment and intervention, and more efficient dissemination of comparative information through common language. No harm or added cost is perceived at this time. RECOMMENDATIONS: (1) A diastolic blood pressure of 90 mm Hg or more should be the criterion for a diagnosis of hypertension in pregnancy and should trigger investigation and management. Except for very high diastolic readings (110 mm Hg or more), all diastolic readings of 90 mm Hg or more should be confirmed after 4 hours. (2) A regularly calibrated mercury sphygmomanometer, with an appropriate-sized cuff, is the instrument of choice. A rest period of 10 minutes should be allowed before taking the blood pressure. The woman should be sitting upright and the cuff positioned at the level of the heart. (3) Both Korotkoff phase IV and V sounds should be recorded, but the phase IV sound should be used for initiating clinical investigation and management. (4) A urine protein level of more than 0.3 g/d should be the criterion for a diagnosis of proteinuria; 24-hour urine collection should be the standard method for determining proteinuria. (5) Edema and weight gain should not be used as diagnostic criteria. (6) Hypertensive disorders diagnosed during pregnancy should be classified as pre-existing hypertension; gestational hypertension with or without proteinuria; pre-existing hypertension with superimposed gestational hypertension with proteinuria; and unclassifiable antenatally but final classification 42 days after delivery. VALIDATION: Except for expert opinions and reviews solicited for this project, these recommendations need to be field tested and validated in Canada. Guidelines endorsed by the Canadian Hypertension Society and the Society of Obstetricians and Gynaecologists of Canada.

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Selected References

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  1. Brown M. A., Reiter L., Smith B., Buddle M. L., Morris R., Whitworth J. A. Measuring blood pressure in pregnant women: a comparison of direct and indirect methods. Am J Obstet Gynecol. 1994 Sep;171(3):661–667. doi: 10.1016/0002-9378(94)90079-5. [DOI] [PubMed] [Google Scholar]
  2. Brown M. A., Whitworth J. A. Recording diastolic blood pressure in pregnancy. BMJ. 1991 Jul 13;303(6794):120–121. doi: 10.1136/bmj.303.6794.120-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown V. A., Sawers R. S., Parsons R. J., Duncan S. L., Cooke I. D. The value of antenatal cardiotocography in the management of high-risk pregnancy: a randomized controlled trial. Br J Obstet Gynaecol. 1982 Sep;89(9):716–722. doi: 10.1111/j.1471-0528.1982.tb05097.x. [DOI] [PubMed] [Google Scholar]
  4. Burrows R. F., Hunter D. J., Andrew M., Kelton J. G. A prospective study investigating the mechanism of thrombocytopenia in preeclampsia. Obstet Gynecol. 1987 Sep;70(3 Pt 1):334–338. [PubMed] [Google Scholar]
  5. Carruthers S. G., Larochelle P., Haynes R. B., Petrasovits A., Schiffrin E. L. Report of the Canadian Hypertension Society Consensus Conference: 1. Introduction. CMAJ. 1993 Aug 1;149(3):289–293. [PMC free article] [PubMed] [Google Scholar]
  6. Chesley L. C., Sibai B. M. Clinical significance of elevated mean arterial pressure in the second trimester. Am J Obstet Gynecol. 1988 Aug;159(2):275–279. doi: 10.1016/s0002-9378(88)80067-x. [DOI] [PubMed] [Google Scholar]
  7. Conde-Agudelo A., Lede R., Belizán J. Evaluation of methods used in the prediction of hypertensive disorders of pregnancy. Obstet Gynecol Surv. 1994 Mar;49(3):210–222. doi: 10.1097/00006254-199403000-00027. [DOI] [PubMed] [Google Scholar]
  8. Cunningham F. G., Lindheimer M. D. Hypertension in pregnancy. N Engl J Med. 1992 Apr 2;326(14):927–932. doi: 10.1056/NEJM199204023261405. [DOI] [PubMed] [Google Scholar]
  9. Cunningham F. G., Lowe T., Guss S., Mason R. Erythrocyte morphology in women with severe preeclampsia and eclampsia. Preliminary observations with scanning electron microscopy. Am J Obstet Gynecol. 1985 Oct 15;153(4):358–363. doi: 10.1016/0002-9378(85)90071-7. [DOI] [PubMed] [Google Scholar]
  10. Davey D. A., MacGillivray I. The classification and definition of the hypertensive disorders of pregnancy. Am J Obstet Gynecol. 1988 Apr;158(4):892–898. doi: 10.1016/0002-9378(88)90090-7. [DOI] [PubMed] [Google Scholar]
  11. Easterling T. R., Benedetti T. J., Schmucker B. C., Millard S. P. Maternal hemodynamics in normal and preeclamptic pregnancies: a longitudinal study. Obstet Gynecol. 1990 Dec;76(6):1061–1069. [PubMed] [Google Scholar]
  12. Easterling T. R., Watts D. H., Schmucker B. C., Benedetti T. J. Measurement of cardiac output during pregnancy: validation of Doppler technique and clinical observations in preeclampsia. Obstet Gynecol. 1987 Jun;69(6):845–850. [PubMed] [Google Scholar]
  13. Fay R. A., Bromham D. R., Brooks J. A., Gebski V. J. Platelets and uric acid in the prediction of preeclampsia. Am J Obstet Gynecol. 1985 Aug 15;152(8):1038–1039. doi: 10.1016/0002-9378(85)90555-1. [DOI] [PubMed] [Google Scholar]
  14. Fay R. A., Hughes A. O., Farron N. T. Platelets in pregnancy: hyperdestruction in pregnancy. Obstet Gynecol. 1983 Feb;61(2):238–240. [PubMed] [Google Scholar]
  15. Fenakel K., Fenakel G., Appelman Z., Lurie S., Katz Z., Shoham Z. Nifedipine in the treatment of severe preeclampsia. Obstet Gynecol. 1991 Mar;77(3):331–337. [PubMed] [Google Scholar]
  16. Flynn A. M., Kelly J., Mansfield H., Needham P., O'Conor M., Viegas O. A randomized controlled trial of non-stress antepartum cardiotocography. Br J Obstet Gynaecol. 1982 Jun;89(6):427–433. doi: 10.1111/j.1471-0528.1982.tb03631.x. [DOI] [PubMed] [Google Scholar]
  17. Franx A., van der Post J. A., Elfering I. M., Veerman D. P., Merkus H. M., Boer K., van Montfrans G. A. Validation of automated blood pressure recording in pregnancy. Br J Obstet Gynaecol. 1994 Jan;101(1):66–69. doi: 10.1111/j.1471-0528.1994.tb13013.x. [DOI] [PubMed] [Google Scholar]
  18. Gaber L. W., Spargo B. H., Lindheimer M. D. Renal pathology in pre-eclampsia. Baillieres Clin Obstet Gynaecol. 1987 Dec;1(4):971–995. doi: 10.1016/s0950-3552(87)80045-7. [DOI] [PubMed] [Google Scholar]
  19. Gibson B., Hunter D., Neame P. B., Kelton J. G. Thrombocytopenia in preeclampsia and eclampsia. Semin Thromb Hemost. 1982 Jul;8(3):234–247. doi: 10.1055/s-2007-1005054. [DOI] [PubMed] [Google Scholar]
  20. Giles C., Inglis T. C. Thrombocytopenia and macrothrombocytosis in gestational hypertension. Br J Obstet Gynaecol. 1981 Nov;88(11):1115–1119. doi: 10.1111/j.1471-0528.1981.tb01764.x. [DOI] [PubMed] [Google Scholar]
  21. Grant A., Elbourne D., Valentin L., Alexander S. Routine formal fetal movement counting and risk of antepartum late death in normally formed singletons. Lancet. 1989 Aug 12;2(8659):345–349. doi: 10.1016/s0140-6736(89)90535-7. [DOI] [PubMed] [Google Scholar]
  22. Helewa M., Heaman M., Robinson M. A., Thompson L. Community-based home-care program for the management of pre-eclampsia: an alternative. CMAJ. 1993 Sep 15;149(6):829–834. [PMC free article] [PubMed] [Google Scholar]
  23. Hill L. M. Metabolism of uric acid in normal and toxemic pregnancy. Mayo Clin Proc. 1978 Nov;53(11):743–751. [PubMed] [Google Scholar]
  24. Hofmeyr G. J., Pattinson R., Buckley D., Jennings J., Redman C. W. Umbilical artery resistance index as a screening test for fetal well-being. II: Randomized feasibility study. Obstet Gynecol. 1991 Sep;78(3 Pt 1):359–362. [PubMed] [Google Scholar]
  25. Johenning A. R., Barron W. M. Indirect blood pressure measurement in pregnancy: Korotkoff phase 4 versus phase 5. Am J Obstet Gynecol. 1992 Sep;167(3):577–580. doi: 10.1016/s0002-9378(11)91552-x. [DOI] [PubMed] [Google Scholar]
  26. Kidd L. C., Patel N. B., Smith R. Non-stress antenatal cardiotocography--a prospective randomized clinical trial. Br J Obstet Gynaecol. 1985 Nov;92(11):1156–1159. doi: 10.1111/j.1471-0528.1985.tb03029.x. [DOI] [PubMed] [Google Scholar]
  27. Kitzmiller J. L., Lang J. E., Yelenosky P. F., Lucas W. E. Hematologic assays in pre-eclampsia. Am J Obstet Gynecol. 1974 Feb 1;118(3):362–367. doi: 10.1016/s0002-9378(16)33794-2. [DOI] [PubMed] [Google Scholar]
  28. Kuo V. S., Koumantakis G., Gallery E. D. Proteinuria and its assessment in normal and hypertensive pregnancy. Am J Obstet Gynecol. 1992 Sep;167(3):723–728. doi: 10.1016/s0002-9378(11)91578-6. [DOI] [PubMed] [Google Scholar]
  29. Kyle P. M., Clark S. J., Buckley D., Kissane J., Coats A. J., de Swiet M., Redman C. W. Second trimester ambulatory blood pressure in nulliparous pregnancy: a useful screening test for pre-eclampsia? Br J Obstet Gynaecol. 1993 Oct;100(10):914–919. doi: 10.1111/j.1471-0528.1993.tb15106.x. [DOI] [PubMed] [Google Scholar]
  30. Lumley J., Lester A., Anderson I., Renou P., Wood C. A randomized trial of weekly cardiotocography in high-risk obstetric patients. Br J Obstet Gynaecol. 1983 Nov;90(11):1018–1026. doi: 10.1111/j.1471-0528.1983.tb06439.x. [DOI] [PubMed] [Google Scholar]
  31. López M. C., Belizán J. M., Villar J., Bergel E. The measurement of diastolic blood pressure during pregnancy: which Korotkoff phase should be used? Am J Obstet Gynecol. 1994 Feb;170(2):574–578. doi: 10.1016/s0002-9378(94)70230-6. [DOI] [PubMed] [Google Scholar]
  32. MacGillivray I., Rose G. A., Rowe B. Blood pressure survey in pregnancy. Clin Sci. 1969 Oct;37(2):395–407. [PubMed] [Google Scholar]
  33. Manning F. A., Lange I. R., Morrison I., Harman C. R. Fetal biophysical profile score and the nonstress test: a comparative trial. Obstet Gynecol. 1984 Sep;64(3):326–331. [PubMed] [Google Scholar]
  34. Martin J. N., Jr, Blake P. G., Lowry S. L., Perry K. G., Jr, Files J. C., Morrison J. C. Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis, elevated liver enzymes, and low platelet count: how rapid is postpartum recovery? Obstet Gynecol. 1990 Nov;76(5 Pt 1):737–741. doi: 10.1097/00006250-199011000-00001. [DOI] [PubMed] [Google Scholar]
  35. Marx G. F., Schwalbe S. S., Cho E., Whitty J. E. Automated blood pressure measurements in laboring women: are they reliable? Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):796–798. doi: 10.1016/s0002-9378(12)90822-4. [DOI] [PubMed] [Google Scholar]
  36. McKay D. G. Hematologic evidence of disseminated intravascular coagulation in eclampsia. Obstet Gynecol Surv. 1972 Jun;27(6):399–417. doi: 10.1097/00006254-197206000-00001. [DOI] [PubMed] [Google Scholar]
  37. McParland P., Pearce J. M. Doppler blood flow in pregnancy. Placenta. 1988 Jul-Aug;9(4):427–450. doi: 10.1016/0143-4004(88)90055-0. [DOI] [PubMed] [Google Scholar]
  38. NELSON T. R. A clinical study of pre-eclampsia. II. J Obstet Gynaecol Br Emp. 1955 Feb;62(1):58–66. doi: 10.1111/j.1471-0528.1955.tb14095.x. [DOI] [PubMed] [Google Scholar]
  39. Newnham J. P., O'Dea M. R., Reid K. P., Diepeveen D. A. Doppler flow velocity waveform analysis in high risk pregnancies: a randomized controlled trial. Br J Obstet Gynaecol. 1991 Oct;98(10):956–963. doi: 10.1111/j.1471-0528.1991.tb15332.x. [DOI] [PubMed] [Google Scholar]
  40. Nisell H., Lintu H., Lunell N. O., Möllerström G., Pettersson E. Blood pressure and renal function seven years after pregnancy complicated by hypertension. Br J Obstet Gynaecol. 1995 Nov;102(11):876–881. doi: 10.1111/j.1471-0528.1995.tb10874.x. [DOI] [PubMed] [Google Scholar]
  41. Odendaal H. J., Pattinson R. C., Bam R., Grove D., Kotze T. J. Aggressive or expectant management for patients with severe preeclampsia between 28-34 weeks' gestation: a randomized controlled trial. Obstet Gynecol. 1990 Dec;76(6):1070–1075. [PubMed] [Google Scholar]
  42. Page E. W., Christianson R. Influence of blood pressure changes with and without proteinuria upon outcome of pregnancy. Am J Obstet Gynecol. 1976 Dec 1;126(7):821–833. doi: 10.1016/0002-9378(76)90671-2. [DOI] [PubMed] [Google Scholar]
  43. Pattinson R. C., Odendaal H. J., du Toit R. Conservative management of severe proteinuric hypertension before 28 weeks' gestation. S Afr Med J. 1988 May 7;73(9):516–518. [PubMed] [Google Scholar]
  44. Peek M. J., Horvath J. S., Child A. G., Henderson-Smart D. J., Peat B., Gillin A. Maternal and neonatal outcome of patients classified according to the Australasian Society for the Study of Hypertension in Pregnancy Consensus Statement. Med J Aust. 1995 Feb 20;162(4):186–189. doi: 10.5694/j.1326-5377.1995.tb126018.x. [DOI] [PubMed] [Google Scholar]
  45. Peek M., Shennan A., Halligan A., Lambert P. C., Taylor D. J., De Swiet M. Hypertension in pregnancy: which method of blood pressure measurement is most predictive of outcome? Obstet Gynecol. 1996 Dec;88(6):1030–1033. doi: 10.1016/S0029-7844(96)00350-X. [DOI] [PubMed] [Google Scholar]
  46. Perry I. J., Stewart B. A., Brockwell J., Khan M., Davies P., Beevers D. G., Luesley D. M. Recording diastolic blood pressure in pregnancy. BMJ. 1990 Nov 24;301(6762):1198–1198. doi: 10.1136/bmj.301.6762.1198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Perry K. G., Jr, Martin J. N., Jr Abnormal hemostasis and coagulopathy in preeclampsia and eclampsia. Clin Obstet Gynecol. 1992 Jun;35(2):338–350. [PubMed] [Google Scholar]
  48. Platt L. D., Walla C. A., Paul R. H., Trujillo M. E., Loesser C. V., Jacobs N. D., Broussard P. M. A prospective trial of the fetal biophysical profile versus the nonstress test in the management of high-risk pregnancies. Am J Obstet Gynecol. 1985 Nov 15;153(6):624–633. [PubMed] [Google Scholar]
  49. Pritchard J. A., Cunningham F. G., Mason R. A. Coagulation changes in eclampsia: their frequency and pathogenesis. Am J Obstet Gynecol. 1976 Apr 15;124(8):855–864. doi: 10.1016/s0002-9378(16)33390-7. [DOI] [PubMed] [Google Scholar]
  50. Pritchard J. A., Cunningham F. G., Pritchard S. A. The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. Am J Obstet Gynecol. 1984 Apr 1;148(7):951–963. doi: 10.1016/0002-9378(84)90538-6. [DOI] [PubMed] [Google Scholar]
  51. Proietti A. B., Johnson M. J., Proietti F. A., Repke J. T., Bell W. R. Assessment of fibrin(ogen) degradation products in preeclampsia using immunoblot, enzyme-linked immunosorbent assay, and latex-based agglutination. Obstet Gynecol. 1991 May;77(5):696–700. [PubMed] [Google Scholar]
  52. Redman C. W., Jefferies M. Revised definition of pre-eclampsia. Lancet. 1988 Apr 9;1(8589):809–812. doi: 10.1016/s0140-6736(88)91667-4. [DOI] [PubMed] [Google Scholar]
  53. Reinthaller A., Mursch-Edlmayr G., Tatra G. Thrombin-antithrombin III complex levels in normal pregnancy with hypertensive disorders and after delivery. Br J Obstet Gynaecol. 1990 Jun;97(6):506–510. doi: 10.1111/j.1471-0528.1990.tb02520.x. [DOI] [PubMed] [Google Scholar]
  54. Retzke U., Graf H. Häufigkeit der Schwangerschaftshypertonie in Abhängigkeit von der Hypertoniedefinition. Zentralbl Gynakol. 1994;116(2):73–75. [PubMed] [Google Scholar]
  55. Romero R., Mazor M., Lockwood C. J., Emamian M., Belanger K. P., Hobbins J. C., Duffy T. Clinical significance, prevalence, and natural history of thrombocytopenia in pregnancy-induced hypertension. Am J Perinatol. 1989 Jan;6(1):32–38. doi: 10.1055/s-2007-999540. [DOI] [PubMed] [Google Scholar]
  56. Sagen N., Haram K., Nilsen S. T. Serum urate as a predictor of fetal outcome in severe pre-eclampsia. Acta Obstet Gynecol Scand. 1984;63(1):71–75. doi: 10.3109/00016348409156277. [DOI] [PubMed] [Google Scholar]
  57. Saleh A. A., Bottoms S. F., Welch R. A., Ali A. M., Mariona F. G., Mammen E. F. Preeclampsia, delivery, and the hemostatic system. Am J Obstet Gynecol. 1987 Aug;157(2):331–336. doi: 10.1016/s0002-9378(87)80163-1. [DOI] [PubMed] [Google Scholar]
  58. Shennan A. H., Kissane J., de Swiet M. Validation of the SpaceLabs 90207 ambulatory blood pressure monitor for use in pregnancy. Br J Obstet Gynaecol. 1993 Oct;100(10):904–908. doi: 10.1111/j.1471-0528.1993.tb15104.x. [DOI] [PubMed] [Google Scholar]
  59. Shennan A., Gupta M., Halligan A., Taylor D. J., de Swiet M. Lack of reproducibility in pregnancy of Korotkoff phase IV as measured by mercury sphygmomanometry. Lancet. 1996 Jan 20;347(8995):139–142. doi: 10.1016/s0140-6736(96)90338-4. [DOI] [PubMed] [Google Scholar]
  60. Sibai B. M. Diagnosis and management of chronic hypertension in pregnancy. Obstet Gynecol. 1991 Sep;78(3 Pt 1):451–461. [PubMed] [Google Scholar]
  61. Sibai B. M. Hypertension in pregnancy. Obstet Gynecol Clin North Am. 1992 Dec;19(4):615–632. [PubMed] [Google Scholar]
  62. Sibai B. M. Pitfalls in diagnosis and management of preeclampsia. Am J Obstet Gynecol. 1988 Jul;159(1):1–5. doi: 10.1016/0002-9378(88)90482-6. [DOI] [PubMed] [Google Scholar]
  63. Sibai B. M., Taslimi M. M., el-Nazer A., Amon E., Mabie B. C., Ryan G. M. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia. Am J Obstet Gynecol. 1986 Sep;155(3):501–509. doi: 10.1016/0002-9378(86)90266-8. [DOI] [PubMed] [Google Scholar]
  64. Sibai B. M., Taslimi M., Abdella T. N., Brooks T. F., Spinnato J. A., Anderson G. D. Maternal and perinatal outcome of conservative management of severe preeclampsia in midtrimester. Am J Obstet Gynecol. 1985 May 1;152(1):32–37. [PubMed] [Google Scholar]
  65. Thornton C. A., Bonnar J. Factor VIII-related antigen and factor VIII coagulant activity in normal and pre-eclamptic pregnancy. Br J Obstet Gynaecol. 1977 Dec;84(12):919–923. doi: 10.1111/j.1471-0528.1977.tb12521.x. [DOI] [PubMed] [Google Scholar]
  66. Trofatter K. F., Jr, Howell M. L., Greenberg C. S., Hage M. L. Use of the fibrin D-dimer in screening for coagulation abnormalities in preeclampsia. Obstet Gynecol. 1989 Mar;73(3 Pt 1):435–440. [PubMed] [Google Scholar]
  67. Trudinger B. J., Cook C. M., Giles W. B., Connelly A., Thompson R. S. Umbilical artery flow velocity waveforms in high-risk pregnancy. Randomised controlled trial. Lancet. 1987 Jan 24;1(8526):188–190. doi: 10.1016/s0140-6736(87)90003-1. [DOI] [PubMed] [Google Scholar]
  68. Villar J., Repke J., Markush L., Calvert W., Rhoads G. The measuring of blood pressure during pregnancy. Am J Obstet Gynecol. 1989 Oct;161(4):1019–1024. doi: 10.1016/0002-9378(89)90777-1. [DOI] [PubMed] [Google Scholar]
  69. Visser W., Wallenburg H. C. Central hemodynamic observations in untreated preeclamptic patients. Hypertension. 1991 Jun;17(6 Pt 2):1072–1077. doi: 10.1161/01.hyp.17.6.1072. [DOI] [PubMed] [Google Scholar]
  70. Weenink G. H., Borm J. J., Ten Cate J. W., Treffers P. E. Antithrombin III levels in normotensive and hypertensive pregnancy. Gynecol Obstet Invest. 1983;16(4):230–242. doi: 10.1159/000299264. [DOI] [PubMed] [Google Scholar]
  71. Weiner C. P., Brandt J. Plasma antithrombin III activity: an aid in the diagnosis of preeclampsia-eclampsia. Am J Obstet Gynecol. 1982 Feb 1;142(3):275–281. doi: 10.1016/0002-9378(82)90730-x. [DOI] [PubMed] [Google Scholar]
  72. Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol. 1982 Jan 15;142(2):159–167. doi: 10.1016/s0002-9378(16)32330-4. [DOI] [PubMed] [Google Scholar]
  73. Wichman K., Rydén G., Wichman M. The influence of different positions and Korotkoff sounds on the blood pressure measurements in pregnancy. Acta Obstet Gynecol Scand Suppl. 1984;118:25–28. doi: 10.3109/00016348409157118. [DOI] [PubMed] [Google Scholar]
  74. Wittmann B. K., Murphy K. J., King J. F., Yuen B. H., Shaw D., Wittmann A. G. Maternal mortality in British Columbia in 1971-86. CMAJ. 1988 Jul 1;139(1):37–40. [PMC free article] [PubMed] [Google Scholar]

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