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. 1998 May 19;158(10):1303–1305.

Ethics in clinical research: searching for absolutes

K S Joseph
PMCID: PMC1229324  PMID: 9614823

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angell M. The ethics of clinical research in the Third World. N Engl J Med. 1997 Sep 18;337(12):847–849. doi: 10.1056/NEJM199709183371209. [DOI] [PubMed] [Google Scholar]
  2. Baer N. Debate about placebos points to issue surrounded by many shades of grey. CMAJ. 1996 Nov 15;155(10):1475–1476. [PMC free article] [PubMed] [Google Scholar]
  3. Bearman S. I., Shpall E. J., Jones R. B., Cagnoni P. J., Ross M. High-dose chemotherapy with autologous hematopoietic progenitor cell support for metastatic and high-risk primary breast cancer. Semin Oncol. 1996 Feb;23(1 Suppl 2):60–67. [PubMed] [Google Scholar]
  4. Bezwoda W. R., Seymour L., Dansey R. D. High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: a randomized trial. J Clin Oncol. 1995 Oct;13(10):2483–2489. doi: 10.1200/JCO.1995.13.10.2483. [DOI] [PubMed] [Google Scholar]
  5. Bhagwanjee S., Muckart D. J., Jeena P. M., Moodley P. Does HIV status influence the outcome of patients admitted to a surgical intensive care unit? A prospective double blind study. BMJ. 1997 Apr 12;314(7087):1077–1084. doi: 10.1136/bmj.314.7087.1077a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brockstein B. E., Williams S. F. High-dose chemotherapy with autologous stem cell rescue for breast cancer: yesterday, today and tomorrow. Stem Cells. 1996 Jan;14(1):79–89. doi: 10.1002/stem.140079. [DOI] [PubMed] [Google Scholar]
  7. Brophy J. M., Joseph L. Bayesian interim statistical analysis of randomised trials. Lancet. 1997 Apr 19;349(9059):1166–1168. doi: 10.1016/S0140-6736(96)06377-5. [DOI] [PubMed] [Google Scholar]
  8. Busuttil R. W., Holt C. D. Tacrolimus (FK506) is superior to cyclosporine in liver transplantation. Transplant Proc. 1997 Feb-Mar;29(1-2):534–538. doi: 10.1016/s0041-1345(96)00630-6. [DOI] [PubMed] [Google Scholar]
  9. Cagnoni P. J., Shpall E. J. High-dose chemotherapy for the treatment of breast and ovarian cancer. Curr Opin Oncol. 1997 Mar;9(2):122–125. doi: 10.1097/00001622-199703000-00003. [DOI] [PubMed] [Google Scholar]
  10. Dennis M., O'Rourke S., Slattery J., Staniforth T., Warlow C. Evaluation of a stroke family care worker: results of a randomised controlled trial. BMJ. 1997 Apr 12;314(7087):1071–1077. doi: 10.1136/bmj.314.7087.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Finkelstein M. O., Levin B., Robbins H. Clinical and prophylactic trials with assured new treatment for those at greater risk: I. A design proposal. Am J Public Health. 1996 May;86(5):691–695. doi: 10.2105/ajph.86.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Freedman B. Equipoise and the ethics of clinical research. N Engl J Med. 1987 Jul 16;317(3):141–145. doi: 10.1056/NEJM198707163170304. [DOI] [PubMed] [Google Scholar]
  13. Halsey N. A., Sommer A., Henderson D. A., Black R. E. Ethics and international research. BMJ. 1997 Oct 18;315(7114):965–966. doi: 10.1136/bmj.315.7114.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kennedy M. J. High-dose chemotherapy of breast cancer: is the question answered? J Clin Oncol. 1995 Oct;13(10):2477–2479. doi: 10.1200/JCO.1995.13.10.2477. [DOI] [PubMed] [Google Scholar]
  15. Kigotho A. W. Another HIV-1 trial loses placebo control. Lancet. 1997 Dec 20;350(9094):1831–1831. doi: 10.1016/S0140-6736(05)63659-8. [DOI] [PubMed] [Google Scholar]
  16. Kigotho A. W. Trial to reduce vertical transmission of HIV-1 on schedule in Uganda. Lancet. 1997 Dec 6;350(9092):1683–1683. doi: 10.1016/S0140-6736(05)64283-3. [DOI] [PubMed] [Google Scholar]
  17. Køber L., Torp-Pedersen C., Cole D., Hampton J. R., Camm A. J. Bayesian interim statistical analysis of randomised trials: the case against. Lancet. 1997 Apr 19;349(9059):1168–1169. doi: 10.1016/s0140-6736(96)11416-1. [DOI] [PubMed] [Google Scholar]
  18. Lerner B. H. Scientific evidence versus therapeutic demand: the introduction of the sulfonamides revisited. Ann Intern Med. 1991 Aug 15;115(4):315–320. doi: 10.7326/0003-4819-115-4-315. [DOI] [PubMed] [Google Scholar]
  19. Lurie P., Wolfe S. M. Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries. N Engl J Med. 1997 Sep 18;337(12):853–856. doi: 10.1056/NEJM199709183371212. [DOI] [PubMed] [Google Scholar]
  20. Mathews J. NCI survey explores the M.D.'s perspective on ABMT trials. J Natl Cancer Inst. 1995 Oct 18;87(20):1510–1511. doi: 10.1093/jnci/87.20.1510. [DOI] [PubMed] [Google Scholar]
  21. Peters W. P. High-dose chemotherapy with autologous bone marrow transplantation for the treatment of breast cancer: yes. Important Adv Oncol. 1995:215–230. [PubMed] [Google Scholar]
  22. Rothman K. J., Michels K. B. The continuing unethical use of placebo controls. N Engl J Med. 1994 Aug 11;331(6):394–398. doi: 10.1056/NEJM199408113310611. [DOI] [PubMed] [Google Scholar]
  23. Smigel K. Women flock to ABMT for breast cancer without final proof. J Natl Cancer Inst. 1995 Jul 5;87(13):952–955. doi: 10.1093/jnci/87.13.952. [DOI] [PubMed] [Google Scholar]
  24. Starzl T. E., Donner A., Eliasziw M., Stitt L., Meier P., Fung J. J., McMichael J. P., Todo S. Randomised trialomania? The multicentre liver transplant trials of tacrolimus. Lancet. 1995 Nov 18;346(8986):1346–1350. doi: 10.1016/s0140-6736(95)92349-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Varmus H., Satcher D. Ethical complexities of conducting research in developing countries. N Engl J Med. 1997 Oct 2;337(14):1003–1005. doi: 10.1056/NEJM199710023371411. [DOI] [PubMed] [Google Scholar]

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