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European Journal of Medical Research logoLink to European Journal of Medical Research
. 2025 Aug 2;30:699. doi: 10.1186/s40001-025-02957-x

Chin soft tissue thickness and mandibular divergency: a cross-sectional study

Nada E Tashkandi 1,, Rahaf Alshahrani 2, Sara Alshanbari 2, Fatima Almarzouq 2, Seren Alshamrani 2, Anfal Busaeed 2, Eman Allam 3
PMCID: PMC12317536  PMID: 40753406

Abstract

Objectives

The aim of the current study was to assess chin characteristics, in terms of soft tissue thickness and mandibular divergency, in a cohort of adult population and explore potential demographic correlations.

Methods

The sample included 465 lateral cephalograms of adult subjects. Cephalometric measurements were recorded to determine the subjects’ anteroposterior and vertical classifications. The soft tissue characteristics of the chin were determined using the upper and lower lip to E line, pogonion to nasion perpendicular, and soft tissue thickness at level of pogonion (Pog), gnathion (Gn) and menton (Me). The differences between the cephalometric parameters based on the age and gender groups as well as the relationship between soft tissue thickness measurements and mandibular divergence angle were statistically analyzed.

Results

ANB angle, soft tissue thickness at the level of Pog point and menton point showed statistically significant differences between male and female subjects (p = 0.00, 0.029, 0.007, respectively). All measured parameters showed statistically significant differences based on the age group except FMA (p = 0.052), L1-MP (p = 0.28), Gn (p = 0.2), and Me (p = 0.42). No significant differences were detected in the mandibular divergency as measured by FMA at different age and gender groups. However, statistically significant differences were detected at different age and gender as measured by SN-GoMe. All parameters showed statistically significant differences among the different mandibular divergency patterns as measured by FMA and SN-GoMe angle except for ANB and Me.

Conclusion

The soft tissue thickness and characteristics of the chin were significantly influenced by age, gender, and malocclusion pattern in the studied sample. These variations are essential considerations for effective orthodontic and orthognathic surgical treatment planning.

Clinical relevance

Malocclusion and mandibular divergence significantly influence the morphology of the chin and surrounding facial structures. This study highlights variations in skeletal and soft tissue parameters across age, gender, and mandibular divergence patterns. These findings are clinically valuable for personalized orthodontic diagnosis and treatment planning and have broader implications in forensic science and anthropological assessments, where accurate interpretation of chin morphology is essential.

Keywords: Chin characteristics, Mandibular divergency, Demographic variation, Soft tissue thickness

Introduction

Chin characteristics is crucial to facial equilibrium and aesthetics. The labio-mental groove, largely determined by the position of the chin and teeth, is a vital component of facial balance and attractiveness [1, 2]. Facial attractiveness is multifactorial and is influenced by a range of biological, psychological, and cultural factors. Certain facial features such as symmetry and well-defined jawline are frequently associated with attractiveness in many cultures. Nowadays, social media has influenced many patients to seek various aesthetic treatments to improve their appearance including procedures to alter chin projection and enhance harmony [1, 2].

In addition to facial harmony, chin characteristics, such as the shape, size, and projection, can influence occlusion and the overall oral health. In children and adolescents, mandibular growth and chin development are tightly related. Functional orthodontic appliances used during growth spurts are mainly utilized to treat skeletal conditions, guide the proper development of the lower jaw and improve the chin’s position. In adults, significant skeletal abnormalities are more challenging, and treatment may require a combination of orthodontics and surgical procedures [3, 4].

One of the main objectives of orthodontic treatment is to persuade balance between the jaws and facial structures. Orthodontic diagnosis and treatment planning therefore requires careful evaluation of the patient’s features on lateral cephalometric radiographs. In order to be critical and descriptive, it is required to express soft tissues and skeletal dimensions, in terms of angles or linear measurements, of each patient and compare it to the population norms. Small differences could be interpreted as normal variations, while the larger differences would indicate structural deviations that need to be addressed [57]. The literature consistently reports on the ethnic variations in the measurements of facial profile [811]. The aim of the current study was to assess chin characteristics, in terms of soft tissue thickness and mandibular divergency, in adult population and explore potential demographic correlations.

Materials and methods

The sample included 465 pretreatment lateral cephalometric radiographs of adult subjects retrieved from the archive of the postgraduate orthodontic clinic at Riyadh Elm University. The study was approved by the ethical review committee of the university (FUGRP/2020/184/248/249). All radiographs were taken with the head in natural position (NHP), lips and tongue in resting position, with the Frankfurt plane parallel to the floor. The inclusion criteria were cephalometric radiographs of subjects with no history of previous orthodontic treatment, competent lips, permanent dentitions, and throats that are clear in the radiographs. Records with developmental abnormalities or craniofacial anomalies and radiographs with patient positioning errors were excluded from the sample. The radiographs were traced for linear and angular measurements recording using the WebCeph program (AssembleCircle Corp., Gyeonggi-do, Republic of Korea) by two investigators. Inter-examiner reliability assessment was done on 10% of cases to assess the degree of agreement among investigators using Cronbach’s alpha test.

Cephalometric landmarks and measurements were recorded to determine the subjects’ anteroposterior and vertical classifications (Table 1). SNA, SNB and ANB angles were used to determine the anteroposterior relationship and classify malocclusion. Subjects were classified based on ANB angles into Class I: 3 ± 2, Class II > 5, and Class III < 1.

Table 1.

Definition of cephalometric points and landmarks used in the study

Landmark Description
Pogonion (Pog) Most anterior point of the mandibular symphysis
Gnathion (Gn) Most anteroinferior point of the mandibular symphysis
Menton (Me) Most inferior point of the mandibular symphysis midline
SNA The angle between sella–nasion plane (SN) and nasion–point A line (NA). It indicates if the maxilla is normal, prognathic, or retrognathic
SNB The angle between sella–nasion plane (SN) and nasion–point B line (NB). It indicates if the mandible is normal, prognathic, or retrognathic
ANB The angle between nasion–point A line (NA) and nasion–point B line (NB). It indicates whether the skeletal relationship between the maxilla and mandible is a normal skeletal class I, II or III
FMA Frankfort to mandibular plane angle. Indicates the amount of mandibular divergency. This angle is formed between the Frankfort horizontal plane as drawn from orbitale to porion intersected with the mandibular plane as drawn from gonion to menton
SN-GoMe This represents the mandibular divergency to the anterior cranial base and is formed by projecting a plane from the sella–nasion line in correlation to a line drawn from Go point to Me point
U1-PP The angle between the long axis of the most protruded maxillary incisor and the ANS-PNS (PP) line
L1-MP (IMPA) The angle between the long axis of the most protruded mandibular incisor and the mandibular plane
Upper lip to E line Line drawn from tip of the nose (pronasale) to the tip of the chin (soft tissue pogonion) in correlation with the upper lip
Lower lip to E line Line drawn from tip of the nose (pronasale) to the tip of the chin (soft tissue pogonion) in correlation with the lower lip
Pog to N perp Distance between the line soft tissue pogonion and a perpendicular line to Frankfort tangent to the soft tissue nasion
Pog–Pog’ The soft tissue thickness of chin at level of pogonion was measured as the horizontal distance between pogonion (Pog) and soft tissue pogonion (Pog’) points
Gn–Gn’ Soft tissue thickness of chin at level of gnathion was measured as the horizontal distance between gnathion (Gn) and soft tissue gnathion (Gn’) points
Me–Me’ Soft tissue thickness of chin at level of menton was measured as the horizontal distance between menton (Me) and soft tissue menton (Me’) points

The vertical classification was divided according to Frankfort to mandibular plane angle (FMA) and sella–nasion to gonion–menton angle (SN-GoMe) into normo-divergent (FMA 22–280 or SN-GoMe 27–36°), hyper-divergent (above the norm) and hypo-divergent (below the norm). The dental relationship was determined using U1-PP, L1-MB and the interincisal angle. The soft tissue characteristics of the lips and chin were determined using the upper and lower lip to E line, pogonion to nasion perpendicular, and soft tissue thickness at level of pogonion (Pog), gnathion (Gn) and menton (Me) measurements (Table 1 and Fig. 1).

Fig. 1.

Fig. 1

Cephalometric landmarks and parameters used in the study

Statistical analysis

Post hoc power analysis indicated that a sample size of 465 pretreatment lateral cephalometric radiographs provided greater than 90% power to detect small to moderate effect sizes at an alpha level of 0.05 for comparisons among mandibular divergence groups. This suggests that the study was sufficiently powered to identify statistically significant differences in soft tissue thickness measurements across groups. Intraclass correlation coefficient (ICC) test was utilized to determine interrater reliability. A two-way analysis of variance and post hoc tests (Bonferroni) were used for multiple comparisons (cephalometric linear and angular measurements). Student’s t-test was utilized to assess the difference between the cephalometric parameters based on the age groups. Kruskal–Wallis one-way analysis of variance was used to compare the studied parameters between male and female subjects. Comparison of differences between genders within each group was conducted using Mann–Whitney test. The Pearson correlation coefficient gauged the relationship between soft tissue thickness measurements and mandibular divergence angle. A p-value of less than 0.05 was considered significant and the data were analyzed using IBM-SPSS for Windows version 28.0 (SPSS Inc., Chicago, IL).

Results

The ICC test indicated an inter-examiner reliability of almost 0.84 for all measurements. A total of 465 subjects were included in the final analysis (45.5% male and 54.5% female, mean age of 19.26 ± 7.13 years). Descriptive statistics of the included sample and the selected cephalometric parameters are presented in Tables 2 and 3. The subjects were categorized based on their AP and vertical classifications (Fig. 2).

Table 2.

Pogonion (Pog–Pog’), gnathion (Gn–Gn’), and menton (Me–Me’) measurements according to the AP and vertical classifications

n Mean SD
ANB° Class I 193 Pog 12.06 2.61
Gn 9.06 2.52
Me 7.46 2.17
Class II 180 Pog 12.69 3.50
Gn 9.11 2.79
Me 7.27 2.04
Class III 103 Pog 12.74 3.00
Gn 9.74 2.61
Me 8.39 2.28
FMA° Normo-divergent 161 Pog 12.12 3.06
Gn 9.07 2.60
Me 7.56 2.18
Hyper-divergent 217 Pog 12.18 2.51
Gn 8.74 2.40
Me 7.42 2.15
Hypo-divergent 98 Pog 13.57 3.81
Gn 10.56 2.85
Me 8.01 2.23
SN-GoMe° Normo-divergent 180 Pog 12.30 2.89
Gn 9.22 2.60
Me 7.69 2.34
Hyper-divergent 232 Pog 12.14 2.57
Gn 8.84 2.34
Me 7.43 2.00
Hypo-divergent 64 Pog 13.97 4.42
Gn 10.63 3.35
Me 7.86 2.36

Table 3.

Descriptive statistics of the cephalometric measurements

Variables Mean SD Minimum Maximum
Age 19.26 7.13 6.00 47.00
SNA° 82.31 4.56 62.70 99.81
SNB° 78.70 4.50 60.16 92.78
ANB° 3.62 3.68 − 11.69 14.19
FMA° 27.44 6.70 3.70 45.96
Sn_GoMe° 35.73 7.49 9.19 55.83
U1_PP° 116.85 7.70 95.80 143.95
L1_MP (IMPA) ° 92.60 10.62 58.44 133.25
Ulip_E line (mm) − 1.97 3.03 − 13.93 7.55
L lip_E line (mm) 0.70 2.89 − 11.28 11.86
Pog_N perp (mm) − 4.65 7.48 − 32.44 19.08
Pog 12.44 3.06 1.92 30.74
Gn 9.23 2.65 3.66 23.01
Me 7.59 2.19 2.59 18.35

Fig. 2.

Fig. 2

Anteroposterior and vertical classification of the included sample

According to the FMA values, the sample distribution was 33.8% normo-divergent; 45.6% hyper-divergent, and 20.6% hypo-divergent. The SN-GoMe values indicated a distribution of 37.8% normo-divergent, 47.6% hyper-divergent, and 13.4% hypo-divergent (Table 2).

ANB angle, soft tissue thickness at the level of Pog point and menton point showed statistically significant differences between male and female subjects (p = 0.00, 0.029, 0.007, respectively) while all other measured parameters did not show significant differences (Table 4). All measured parameters showed statistically significant differences based on the age group except FMA (p = 0.052), L1-MP (p = 0.28), Gn (p = 0.2), and Me (p = 0.42) (Table 5).

Table 4.

Comparison of cephalometric measurements based on gender

Variables Male Female p
Mean SD Mean SD
SNA° 82.07 4.75 82.52 4.40 0.28
SNB° 79.09 4.87 78.37 4.14 0.087
ANB° 2.92 3.88 4.21 3.40 0.000
FMA° 26.93 6.53 27.87 6.83 0.128
Sn_GoMe° 35.10 7.44 36.27 7.51 0.089
U1_PP° 117.15 8.12 116.60 7.34 0.439
L1_MP (IMPA) ° 91.93 10.75 93.17 10.50 0.202
Ulip_E line (mm) − 2.20 3.28 − 1.77 2.79 0.131
L lip_E line (mm) 0.63 2.94 0.76 2.85 0.620
Pog_N perp (mm) − 4.22 7.77 − 5.01 7.23 0.254
Pog 12.78 3.17 12.17 2.93 0.029
Gn 9.36 2.64 9.11 2.66 0.299
Me 7.89 2.29 7.34 2.06 0.007

Table 5.

Comparison of cephalometric measurements based on age group

Variables  ≤ 17  > 17 p
Mean SD Mean SD
SNA° 81.73 4.30 82.90 4.74 0.005
SNB° 77.71 4.29 79.68 4.49 0.000
ANB° 3.99 3.33 3.25 3.97 0.028
FMA° 28.04 6.92 26.85 6.45 0.052
Sn_GoMe° 36.75 7.57 34.73 7.29 0.003
U1_PP° 116.13 7.32 117.56 8.01 0.042
L1_MP (IMPA) ° 92.08 10.24 93.13 10.98 0.282
Ulip_E line (mm) − 1.20 2.69 − 2.72 3.16 0.000
L lip_E line (mm) 1.13 2.80 0.28 2.92 0.001
Pog_N perp (mm) − 5.89 6.99 − 3.42 7.77 0.000
Pog 12.08 2.78 12.81 3.27 0.009
Gn 9.07 2.51 9.38 2.79 0.202
Me 7.51 2.10 7.67 2.27 0.420

No statistically significant differences were detected in the mandibular divergency as measured by FMA at different age groups and different gender. However, statistically significant differences were detected at different age and gender as measured by SN-GoMe (Table 6). In addition, all parameters showed statistically significant differences among the different mandibular divergency patterns as measured by FMA and SN-GoMe angle except for ANB and Me (Tables 7 and 8).

Table 6.

Distribution of divergence based on the FMA and Sn-GoME

Variables FMA Sn-GoMe
Normo Hyper Hypo p Normo Hyper Hypo p
n % n % n % n % n % n %
Age  ≤ 17 71 44.10 121 55.80 45 45.90 0.056 88 48.90 126 54.30 23 35.90 0.032
 > 17 90 55.90 96 44.20 53 54.10 92 51.10 106 45.70 41 64.10
Total 161 100.00 217 100.00 98 100 180 100.00 232 100.00 64 100.00
Gender Male 82 50.90 90 41.50 45 45.90 0.188 97 53.90 90 38.80 30 46.90 0.009
Female 79 49.10 127 58.50 53 54.10 83 46.10 142 61.20 34 53.10
Total 161 100.00 217 100.00 98 100 180 100.00 232 100.00 64 100

Table 7.

Categories of divergence and cephalometric variables based on FMA

Variables Normo-divergence Hyper-divergence Hypo-divergence p
Mean SD Mean SD Mean SD
SNA° 82.97 4.15A 80.79 4.16B 84.61 4.87C  < 0.001
SNB° 79.55 4.08A 76.82 3.96B 81.46 4.47C  < 0.001
ANB° 3.46 3.53 3.97 3.18 3.13 4.74 0.133
FMA° 25.35 1.75A 33.22 3.78 B 18.09 3.60C  < 0.001
Sn_GoMe° 33.82 3.75A 41.51 4.80B 26.11 5.09C  < 0.001
U1_PP° 117.12 7.62A 114.45 6.81B 121.72 7.38C  < 0.001
L1_MP (IMPA) ° 92.87 9.30A 88.42 7.93B 101.42 12.34C  < 0.001
Ulip_E line (mm) − 2.20 3.13A − 1.38 2.86B − 2.88 2.96A  < 0.001
L lip_E line (mm) 0.30 2.72A 1.43 2.88B − 0.23 2.80A  < 0.001
Pog_N perp (mm) − 2.30 6.48A − 8.75 5.98B 0.57 7.14C  < 0.001
Pog 12.12 3.06A 12.18 2.51A 13.57 3.81B  < 0.001
Gn 9.07 2.60A 8.74 2.40A 10.56 2.85B  < 0.001
Me 7.56 2.18 7.42 2.15 8.01 2.23 0.082

Table 8.

Categories of divergence and cephalometric variables based on Sn-GoMe

Variables Normo Hyper Hypo p
Mean SD Mean SD Mean SD
SNA° 83.53 3.94A 80.25 3.82B 86.4 4.73C  < 0.001
SNB° 80.08 3.9A 76.39 3.6B 83.2 4.05C  < 0.001
ANB° 3.41 3.52 3.86 3.19 3.35 5.38 0.395
FMA° 24.85 3.36A 32.23 4.85B 17.4 3.76C  < 0.001
Sn_GoMe° 32.38 2.43A 41.82 4.21B 23.1 3.42C  < 0.001
U1_PP° 117.99 6.74A 114.1 7.05B 124 7.51C  < 0.001
L1_MP (IMPA) ° 94.08 8.4A 87.92 8.2B 105 12.28C  < 0.001
Ulip_E line (mm) − 2.35 2.99A − 1.52 2.94B − 2.5 3.26A 0.007
L lip_E line (mm) 0.16 2.84A 1.24 2.82B 0.29 2.96A  < 0.001
Pog_N perp (mm) − 2.87 6.92A − 7.31 6.94B 0.01 7.24C  < 0.001
Pog 12.3 2.89A 12.14 2.57A 14 4.43B  < 0.001
Gn 9.22 2.6A 8.84 2.34A 10.6 3.35B  < 0.001
Me 7.69 2.34 7.43 2 7.86 2.36 0.280

Discussion

Mandibular divergency and chin characteristics differ among ethnic groups, with implications for orthodontic and orthognathic surgical practices. Understanding these anatomical differences is critical, as they can significantly influence treatment planning, aesthetic outcomes, and functional occlusion in patients. Furthermore, variations in chin soft tissue thickness and mandibular divergence have been shown to correlate with different skeletal malocclusion types and facial growth patterns, highlighting the necessity for tailored treatment approaches in diverse populations [12, 13]. The aim of the current study was to assess the variations in chin characteristics in a cohort of adults and explore potential demographic correlations. WebCeph, a cloud-based cephalometric analysis software, was utilized in this study for its convenience and automated landmark detection capabilities. Its key advantages include the user-friendly interface and time efficiency. Its automated analysis functions can reduce human error and improve reproducibility. However, the software offers limited flexibility in terms of customization and integration with other digital workflows compared to some desktop-based alternatives [14].

The study included cephalometric analysis of pretreatment radiographs of 465 adults categorized based on their skeletal sagittal malocclusion and facial divergence types. The results indicated significant differences in ANB angle as well as soft tissue thickness of the chin between male and female subjects. In addition, most of the measured parameters showed significant variation between age groups. These findings are in agreement with previous literature reporting that male subjects typically exhibit a wider, more angular chin compared to female subjects who often present with a taller, more rounded chin structure [13, 15]. Literature has also consistently indicated that mandibular structural and morphological differences are influenced by factors such as facial type, ethnicity, and age [1618].

Within the field of anthropology, there is broad consensus that the concept of universal face balance and attractiveness is challenged by the significant geographic variations in several facial features including the chin. These variations point to either genetic drift or sexual selection that is region-specific [16, 17, 19]. The study by Okumura et al., confirmed ethnic differences in chin characteristics with their results indicating that Koreans demonstrate larger chin volumes compared to Egyptians [17].

The results of the current study also revealed that mandibular divergence patterns, as measured by SN-GoMe, were significantly affected by age and gender classifications. However, they did not show significant difference when measured by FMA. The difference in anatomical landmarks chosen for each parameter may account for the discrepancy. SN-GoMe was found to be a more accurate indicator of mandibular divergence compared to other parameters, including FMA, in several studies [20, 21]. In a study by Ahmed et al., SN-GoMe showed higher reliability, sensitivity, and positive predictive value in assessing vertical growth patterns, particularly in hyper-divergent cases. Therefore, SN-GoMe could be considered a more accurate and reliable parameter for evaluating mandibular divergence [22].

The discrepancies observed in vertical classification using FMA and SN-GoMe suggest the importance of considering multiple angular measurements when evaluating mandibular divergence. These differences reflect the underlying anatomical variations and highlight the need for a comprehensive diagnostic approach rather than reliance on a single angle. Clinically, awareness of such discrepancies is essential in treatment planning, as skeletal growth direction and vertical dimension control play crucial roles especially when planning surgical interventions.

It is well recognized that the morphologic structure of the chin varies depending on malocclusion pattern. Class II malocclusions often show reduced mandibular dimensions and distinct soft tissue profiles compared to Class I and III. Subjects with skeletal Class II asymmetry show smaller condyle angle, condylar height, ramus and mandibular body length on the deviated side compared to the contralateral side. Class I malocclusion is also known to be associated with a larger chin-lip angle and shallower mentolabial furrow compared to Class II. Conversely, Class III malocclusion shows a smaller chin-lip angle and a deeper mentolabial furrow [2325]. The findings of the current study concerning adult population, confirms that malocclusion classification significantly affects the characteristics and morphology of the chin and that the different classes of malocclusion (I, II, and III) exhibit distinct chin hard and soft tissues features. Recognizing these distinctions is essential for precise diagnosis and efficient treatment planning.

This study highlights the importance of assessing chin soft tissue thickness in relation to mandibular divergence for informed facial diagnosis and treatment planning. In orthodontic cases, recognizing soft tissue limitations can guide decisions to minimize adverse profile changes. In cases with severe skeletal discrepancies, soft tissue evaluation aids in determining whether surgical intervention may yield better aesthetic outcomes. Incorporating soft tissue analysis into treatment planning enhances the precision and predictability of both orthodontic and orthognathic outcomes.

The study has several limitations that should be acknowledged. First, the use of a single-institution sample may limit the generalizability of the findings. Second, the retrospective nature of the study introduces inherent limitations such as selection bias and incomplete data records, which may affect the reliability of some variables. Additionally, potential confounding factors could not be fully controlled due to the non-randomized design. Future multicenter, prospective studies with larger and more diverse populations are recommended to validate and extend the findings of this research.

Conclusion

The soft tissue thickness and characteristics of the chin vary significantly among populations and with the different classes of malocclusion. These disparities are also significantly influenced by age and gender. Recognizing these variations can aid clinicians in predicting soft tissue responses, improving facial aesthetic outcomes, and making more informed decisions regarding treatment modalities.

Author contributions

Conceptualization, N.T. and R.A.; Methodology, N.T., F.A. and S.A. X.X.; Validation, N.T., S.A. and A.B.; Formal Analysis, A.B.; Investigation, F.A. and E.A.; Resources, N.T.; Data Curation, R.A.; Writing—Original Draft Preparation, E.A. and N.T.; Writing—Review & Editing, E.A., N.T., R.A., and F.A.

Funding

None.

Data availability

Data will be made available by the corresponding author on reasonable request.

Declarations

Ethics approval and consent to participate

The study was approved by the research ethics committee at Riyadh Elm University (FUGRP/2020/184/248/249).

Competing interests

The authors declare no competing interests.

Footnotes

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

  • 1.Sykes JM, Suárez GA. Chin advancement, augmentation, and reduction as adjuncts to rhinoplasty. Clin Plast Surg. 2016;43(1):295–306. [DOI] [PubMed] [Google Scholar]
  • 2.Papadimitriou A, Kakali L, Pazera P, Doulis I, Kloukos D. Social media and orthodontic treatment from the patient’s perspective: a systematic review. Eur J Orthod. 2020;42(3):231–41. [DOI] [PubMed] [Google Scholar]
  • 3.Andrews LF. The 6-elements orthodontic philosophy: treatment goals, classification, and rules for treating. Am J Orthod Dentofacial Orthop. 2015;148(6):883–7. [DOI] [PubMed] [Google Scholar]
  • 4.Bishara SE, Jakobsen JR, Hession TJ, Treder JE. Soft tissue profile changes from 5 to 45 years of age. Am J Orthod Dentofacial Orthop. 1998;114(6):698–706. [DOI] [PubMed] [Google Scholar]
  • 5.Bishara SE, Abdalla EM, Hoppens BJ. Cephalometric comparisons of dentofacial parameters between Egyptian and North American adolescents. Am J Orthod Dentofacial Orthop. 1990;97(5):413–21. [DOI] [PubMed] [Google Scholar]
  • 6.Alcalde RE, Jinno T, Orsini MG, Sasaki A, Sugiyama RM, Matsumura T. Soft tissue cephalometric norms in Japanese adults. Am J Orthod Dentofacial Orthop. 2000;118(1):84–9. [DOI] [PubMed] [Google Scholar]
  • 7.Basciftci FA, Uysal T, Buyukerkmen A. Determination of Holdaway soft tissue norms in Anatolian Turkish adults. Am J Orthod Dentofacial Orthop. 2003;123(4):395–400. [DOI] [PubMed] [Google Scholar]
  • 8.Uysal T, Baysal A, Yagci A, Sigler LM, McNamara JA Jr. Ethnic differences in the soft tissue profiles of Turkish and European-American young adults with normal occlusions and well-balanced faces. Eur J Orthod. 2012;34(3):296–301. [DOI] [PubMed] [Google Scholar]
  • 9.Hwang HS, Kim WS, McNamara JA Jr. Ethnic differences in the soft tissue profile of Korean and European-American adults with normal occlusions and well-balanced faces. Angle Orthod. 2002;72(1):72–80. [DOI] [PubMed] [Google Scholar]
  • 10.Al-Gunaid T, Yamada K, Yamaki M, Saito I. Soft-tissue cephalometric norms in Yemeni men. Am J Orthod Dentofacial Orthop. 2007;132(5):576.e7-14. [DOI] [PubMed] [Google Scholar]
  • 11.Scheideman GB, Bell WH, Legan HL, Finn RA, Reisch JS. Cephalometric analysis of dentofacial normal. Am J Orthod. 1980;78:404–20. [DOI] [PubMed] [Google Scholar]
  • 12.López DF, Botero JR, Muñoz JM, Cárdenas-Perilla R, Moreno M. Are there mandibular morphological differences in the various facial asymmetry etiologies? A tomographic three-dimensional reconstruction study. J Oral Maxillofac Surg. 2019;77(11):2324–38. [DOI] [PubMed] [Google Scholar]
  • 13.Macari AT, Hanna AE. Comparisons of soft tissue chin thickness in adult patients with various mandibular divergence patterns. Angle Orthod. 2014;84(4):708–14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Yassir YA, Salman AR, Nabbat SA. The accuracy and reliability of WebCeph for cephalometric analysis. J Taibah Univ Med Sci. 2021;17(1):57–66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Sella Tunis T, Hershkovitz I, May H, Vardimon AD, Sarig R, Shpack N. Variation in chin and mandibular symphysis size and shape in males and females: a CT-based study. Int J Environ Res Public Health. 2020;17(12):4249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Lakhiani C, Somenek MT. Gender-related facial analysis. Facial Plast Surg Clin North Am. 2019;27(2):171–7. [DOI] [PubMed] [Google Scholar]
  • 17.Okumura Y, Koizumi S, Suginouchi Y, Hikita Y, Kim Y-I, Adel M, Nadim M, Yamaguchi T. Chin morphology in relation to the skeletal pattern, age, gender, and ethnicity. Appl Sci. 2022;12(24):12717. [Google Scholar]
  • 18.Sella Tunis T, May H, Sarig R, Vardimon AD, Hershkovitz I, Shpack N. Are chin and symphysis morphology facial type-dependent? A computed tomography-based study. Am J Orthod Dentofacial Orthop. 2021;160(1):84–93. [DOI] [PubMed] [Google Scholar]
  • 19.Garvin HM, Ruff CB. Sexual dimorphism in skeletal browridge and chin morphologies determined using a new quantitative method. Am J Phys Anthropol. 2012;147(4):661–70. [DOI] [PubMed] [Google Scholar]
  • 20.Thayer ZM, Dobson SD. Geographic variation in chin shape challenges the universal facial attractiveness hypothesis. PLoS ONE. 2013;8(4): e60681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Azeez SM. Evaluating diagnostic performance of three cephalometric vertical parameters. Indian J Dent Res. 2023;34(1):49–53. [DOI] [PubMed] [Google Scholar]
  • 22.Ahmed M, Shaikh A, Fida M. Diagnostic performance of various cephalometric parameters for the assessment of vertical growth pattern. Dental Press J Orthod. 2016;21(4):41–9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Lv W, Nie Q, Gu Y. Three-dimensional analysis of mandibular characteristics in patients with skeletal Class II malocclusion and chin deviation. Am J Orthod Dentofacial Orthop. 2021;160(3):392–400. [DOI] [PubMed] [Google Scholar]
  • 24.Patil HS, Golwalkar S, Chougule K, Kulkarni NR. Comparative evaluation of soft tissue chin thickness in adult patients with skeletal class ii malocclusion with various vertical growth patterns: a cephalometric study. Folia Med. 2021;63(1):74–80. [DOI] [PubMed] [Google Scholar]
  • 25.Jabbar A, Zia A, Shaikh I, Channar K, Memon A, Jatoi N. Evaluation of soft tissue chin thickness in various skeletal malocclusions. Pakistan Orthod J. 2016;8:62–6. [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Data Availability Statement

Data will be made available by the corresponding author on reasonable request.


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