Abstract
Two patients with mild aortic insufficiency inhaled amyl nitrite during routine echocardiographic examinations. One developed sinus arrest and syncope and the other had pronounced sinus bradycardia. The mechanism of this paradoxical response is unclear. Caution should be exercised when amyl nitrite is administered for diagnostic purposes.
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- AVIADO D. M., Jr, LI T. H., KALOW W., SCHMIDT C. F., TURNBULL G. L., PESKIN G. W., HESS M. E., WEISS A. J. Respiratory and circulatory reflexes from the perfused heart and pulmonary circulation of the dog. Am J Physiol. 1951 May;165(2):261–277. doi: 10.1152/ajplegacy.1951.165.2.261. [DOI] [PubMed] [Google Scholar]
- AVIADO D. M., Jr, SCHMIDT C. F. Cardiovascular and respiratory reflexes from the left side of the heart. Am J Physiol. 1959 Apr;196(4):726–730. doi: 10.1152/ajplegacy.1959.196.4.726. [DOI] [PubMed] [Google Scholar]
- AVIADO D. M., Jr, SCHMIDT C. F. Reflexes from stretch receptors in blood vessels, heart and lungs. Physiol Rev. 1955 Apr;35(2):247–300. doi: 10.1152/physrev.1955.35.2.247. [DOI] [PubMed] [Google Scholar]
- Brundin T., Cernigliaro C. The effect of physical training on the sympathoadrenal response to exercise. Scand J Clin Lab Invest. 1975 Oct;35(6):525–530. [PubMed] [Google Scholar]
- COMROE J. H., Jr, VAN LINGEN B., STROUD R. C., RONCORONI A. Reflex and direct cardiopulmonary effects of 5-OH-tryptamine (serotonin); their possible role in pulmonary embolism and coronary thrombosis. Am J Physiol. 1953 Jun;173(3):379–386. doi: 10.1152/ajplegacy.1953.173.3.379. [DOI] [PubMed] [Google Scholar]
- Come P. C., Pitt B. Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction. Circulation. 1976 Oct;54(4):624–628. doi: 10.1161/01.cir.54.4.624. [DOI] [PubMed] [Google Scholar]
- DAWES G. S., COMROE J. H., Jr Chemoreflexes from the heart and lungs. Physiol Rev. 1954 Apr;34(2):167–201. doi: 10.1152/physrev.1954.34.2.167. [DOI] [PubMed] [Google Scholar]
- Delgado C. E., Pitt B., Taylor D. R., Weisfeldt M. L., Kelly D. T. Role of sublingual nitroglycerin in patients with acute myocardial infarction. Br Heart J. 1975 Apr;37(4):392–396. doi: 10.1136/hrt.37.4.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Epstein S. E., Stampfer M., Beiser G. D. Role of the capacitance and resistance vessels in vasovagal syncope. Circulation. 1968 Apr;37(4):524–533. doi: 10.1161/01.cir.37.4.524. [DOI] [PubMed] [Google Scholar]
- KARP H. R., WEISSLER A. M., HEYMAN A. Vasodepressor syncope: EEG and circulatory changes. Arch Neurol. 1961 Jul;5:94–101. doi: 10.1001/archneur.1961.00450130096011. [DOI] [PubMed] [Google Scholar]
- KONG Y., HEYMAN A., ENTMAN M. L., MCINTOSH H. D. GLOSSOPHARYNGEAL NEURALGIA ASSOCIATED WITH BRADYCARDIA, SYNCOPE, AND SEIZURES. Circulation. 1964 Jul;30:109–113. doi: 10.1161/01.cir.30.1.109. [DOI] [PubMed] [Google Scholar]
- MCINTOSH H. D., ESTES E. H., WARREN J. V. The mechanism of cough syncope. Am Heart J. 1956 Jul;52(1):70–82. doi: 10.1016/0002-8703(56)90119-3. [DOI] [PubMed] [Google Scholar]
- Mason D. T., Braunwald E. The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm. Circulation. 1965 Nov;32(5):755–766. doi: 10.1161/01.cir.32.5.755. [DOI] [PubMed] [Google Scholar]
- Mason D. T., Zelis R., Amsterdam E. A. Actions of the nitrites on the peripheral circulation and myocardial oxygen consumption: significance in the relief of angina pectoris. Chest. 1971 Mar;59(3):296–305. doi: 10.1378/chest.59.3.296. [DOI] [PubMed] [Google Scholar]
- Ross J., Frahm C. J., Braunwald E. THE INFLUENCE OF INTRACARDIAC BARORECEPTORS ON VENOUS RETURN, SYSTEMIC VASCULAR VOLUME AND PERIPHERAL RESISTANCE. J Clin Invest. 1961 Mar;40(3):563–572. doi: 10.1172/JCI104284. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WAYNE H. H. Syncope. Physiological considerations and an analysis of the clinical characteristics in 510 patients. Am J Med. 1961 Mar;30:418–438. doi: 10.1016/0002-9343(61)90051-1. [DOI] [PubMed] [Google Scholar]
- WEISSLER A. M., WARREN J. V., ESTES E. H., Jr, MCINTOSH H. D., LEONARD J. J. Vasodepressor syncope; factors influencing cardiac output. Circulation. 1957 Jun;15(6):875–882. doi: 10.1161/01.cir.15.6.875. [DOI] [PubMed] [Google Scholar]
- Waddington J. K., Matthews H. R., Evans C. C., Ward D. W. Letter: Carcinoma of the oesophagus with "swallow syncope". Br Med J. 1975 Jul 26;3(5977):232–232. doi: 10.1136/bmj.3.5977.232-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Walker J. L., Thames M. D., Abboud F. M., Mark A. L., Klopfenstein H. S. Preferential distribution of inhbititory cardiac receptors in left ventricle of the dog. Am J Physiol. 1978 Aug;235(2):H188–H192. doi: 10.1152/ajpheart.1978.235.2.H188. [DOI] [PubMed] [Google Scholar]
- Weiss S., Wilkins R. W., Haynes F. W. THE NATURE OF CIRCULATORY COLLAPSE INDUCED BY SODIUM NITRITE. J Clin Invest. 1937 Jan;16(1):73–84. doi: 10.1172/JCI100840. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wik B., Hillestad L. Deglutition syncope. Br Med J. 1975 Sep 27;3(5986):747–747. doi: 10.1136/bmj.3.5986.747. [DOI] [PMC free article] [PubMed] [Google Scholar]