Skip to main content
British Heart Journal logoLink to British Heart Journal
. 1986 Mar;55(3):291–294. doi: 10.1136/hrt.55.3.291

Treatment of paroxysmal supraventricular tachycardia with intravenous injection of adenosine triphosphate.

D Saito, M Ueeda, Y Abe, H Tani, T Nakatsu, H Yoshida, S Haraoka, H Nagashima
PMCID: PMC1232168  PMID: 3954911

Abstract

Intravenous adenosine triphosphate rapidly terminated all 11 episodes of paroxysmal supraventricular tachycardia in 10 patients. Eight patients reported side effects but these resolved within 20 seconds and did not require treatment. Adenosine triphosphate is a suitable agent for the rapid termination of paroxysmal supraventricular tachycardia.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Apitz J., Gaissmaier U. Zwischenfall mit tödlichem Ausgang nach intravenöser Injektion von Isoptin. Med Klin. 1971 May 14;66(20):751–755. [PubMed] [Google Scholar]
  2. Belardinelli L., Belloni F. L., Rubio R., Berne R. M. Atrioventricular conduction disturbances during hypoxia. Possible role of adenosine in rabbit and guinea pig heart. Circ Res. 1980 Nov;47(5):684–691. doi: 10.1161/01.res.47.5.684. [DOI] [PubMed] [Google Scholar]
  3. Belardinelli L., Fenton R. A., West A., Linden J., Althaus J. S., Berne R. M. Extracellular action of adenosine and the antagonism by aminophylline on the atrioventricular conduction of isolated perfused guinea pig and rat hearts. Circ Res. 1982 Nov;51(5):569–579. doi: 10.1161/01.res.51.5.569. [DOI] [PubMed] [Google Scholar]
  4. Belardinelli L., Isenberg G. Isolated atrial myocytes: adenosine and acetylcholine increase potassium conductance. Am J Physiol. 1983 May;244(5):H734–H737. doi: 10.1152/ajpheart.1983.244.5.H734. [DOI] [PubMed] [Google Scholar]
  5. Belardinelli L., Mattos E. C., Berne R. M. Evidence for adenosine mediation of atrioventricular block in the ischemic canine myocardium. J Clin Invest. 1981 Jul;68(1):195–205. doi: 10.1172/JCI110235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Belardinelli L., Vogel S., Linden J., Berne R. M. Antiadrenergic action of adenosine on ventricular myocardium in embryonic chick hearts. J Mol Cell Cardiol. 1982 May;14(5):291–294. doi: 10.1016/0022-2828(82)90207-3. [DOI] [PubMed] [Google Scholar]
  7. Belhassen B., Pelleg A. Electrophysiologic effects of adenosine triphosphate and adenosine on the mammalian heart: clinical and experimental aspects. J Am Coll Cardiol. 1984 Aug;4(2):414–424. doi: 10.1016/s0735-1097(84)80233-8. [DOI] [PubMed] [Google Scholar]
  8. Coumel P., Motte G., Gourgon R., Fabiato A., Slama R., Bouvrain Y. Les tachycardies supraventriculaires par rythme réciproque en dehors du syndrome de Wolff-Parkinson-White. Arch Mal Coeur Vaiss. 1970 Jan;63(1):35–73. [PubMed] [Google Scholar]
  9. DiMarco J. P., Sellers T. D., Berne R. M., West G. A., Belardinelli L. Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia. Circulation. 1983 Dec;68(6):1254–1263. doi: 10.1161/01.cir.68.6.1254. [DOI] [PubMed] [Google Scholar]
  10. Greco R., Musto B., Arienzo V., Alborino A., Garofalo S., Marsico F. Treatment of paroxysmal supraventricular tachycardia in infancy with digitalis, adenosine-5'-triphosphate, and verapamil: a comparative study. Circulation. 1982 Sep;66(3):504–508. doi: 10.1161/01.cir.66.3.504. [DOI] [PubMed] [Google Scholar]
  11. Henry P. D. Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. Am J Cardiol. 1980 Dec 1;46(6):1047–1058. doi: 10.1016/0002-9149(80)90366-5. [DOI] [PubMed] [Google Scholar]
  12. James T. N. The chronotropic action of ATP and related compounds studied by direct perfusion of the sinus node. J Pharmacol Exp Ther. 1965 Aug;149(2):233–247. [PubMed] [Google Scholar]
  13. Motté G., Waynberger M., Lebards A., Bouvrain Y. L'adénosine triphosphorique dans les tachycardies paroxystiques. Intérët diagnostique et thérapeutique. Nouv Presse Med. 1972 Dec 16;1(45):3057–3061. [PubMed] [Google Scholar]
  14. Ronca-Testoni S., Borghini F. Degradation of perfused adenine compounds up to uric acid in isolated rat heart. J Mol Cell Cardiol. 1982 Mar;14(3):177–180. doi: 10.1016/0022-2828(82)90116-x. [DOI] [PubMed] [Google Scholar]
  15. Schomerus M., Spiegelhalder B., Stieren B., Eichelbaum M. Physiological disposition of verapamil in man. Cardiovasc Res. 1976 Sep;10(5):605–612. doi: 10.1093/cvr/10.5.605. [DOI] [PubMed] [Google Scholar]
  16. Schrader J., Rubio R., Berne R. M. Inhibition of slow action potentials of guinea pig atrial muscle by adenosine: a possible effect on Ca2+ influx. J Mol Cell Cardiol. 1975 Jun;7(6):427–433. doi: 10.1016/0022-2828(75)90048-6. [DOI] [PubMed] [Google Scholar]
  17. Soler-Soler J., Sagristá-Sauleda J., Cabrera A., Sauleda-Parés J., Iglesias-Berengué J., Permanyer-Miralda G., Roca-Llop J. Effect of verapamil in infants with paroxysmal supraventricular tachycardia. Circulation. 1979 May;59(5):876–879. doi: 10.1161/01.cir.59.5.876. [DOI] [PubMed] [Google Scholar]
  18. Spurrell R. A., Krikler D. M., Sowton E. Effects of verapamil on electrophysiological properties of anomalous atrioventricular connexion in Wolff-Parkinson-White syndrome. Br Heart J. 1974 Mar;36(3):256–264. doi: 10.1136/hrt.36.3.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Urthaler F., James T. N. Effects of adenosine and ATP on AV conduction and on AV junctional rhythm. J Lab Clin Med. 1972 Jan;79(1):96–105. [PubMed] [Google Scholar]
  20. Urthaler F., James T. N. Experimental studies on the pathogenesis of asystole after verapamil in the dog. Am J Cardiol. 1979 Oct;44(4):651–656. doi: 10.1016/0002-9149(79)90283-2. [DOI] [PubMed] [Google Scholar]
  21. Wolff G. S., Sung R. J., Pickoff A., Garcia O. L., Werblin R., Ferrer P. L., Tamer D., Gelband H. The fast-slow form of atrioventricular nodal reentrant tachycardia in children. Am J Cardiol. 1979 Jun;43(6):1181–1188. doi: 10.1016/0002-9149(79)90151-6. [DOI] [PubMed] [Google Scholar]
  22. diMarco J. P., Sellers T. D., Lerman B. B., Greenberg M. L., Berne R. M., Belardinelli L. Diagnostic and therapeutic use of adenosine in patients with supraventricular tachyarrhythmias. J Am Coll Cardiol. 1985 Aug;6(2):417–425. doi: 10.1016/s0735-1097(85)80181-9. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES